Effects of long-term cadmium exposure on growth, antioxidant defense and DNA methylation in juvenile Nile tilapia (Oreochromis niloticus)

Hu, Fengxiao; Li, Yin; Dong, Feilong; Zheng, Mengyan; Zhao, Yixin; Fu, Shirong; Zhang, Weini; Chen, Xinhua

doi:10.1016/j.aquatox.2021.106014

Cited by 19 publications

(5 citation statements)

References 69 publications

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“…A study conducted in Nile tilapias (Oreochromis niloticus) showed that exposure to Cd induces OS, including reduced antioxidant activities and increased MDA and 8-OHdG content, which was related to DNA hypomethylation. A decrease in DNMT and increased expression of TET1 and TET2 were also observed [209]. It should be noted that this study carried out in tilapia was chronic (45 and 90 days); thus, it contradicts the statement that acute Cd exposures are related to hypomethylation, while chronic exposures are related to hypermethylation [21,129].…”

Section: Dna Methylationmentioning

confidence: 53%

Oxidative Stress and Its Role in Cd-Induced Epigenetic Modifications: Use of Antioxidants as a Possible Preventive Strategy

Hernández-Cruz

Arancibia-Hernández

Loyola-Mondragón

et al. 2022

Oxygen

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Oxidative stress (OS) represents one of the main mechanisms of toxicity induced by environmental pollutants such as cadmium (Cd). OS is a natural physiological process where the presence of oxidants, such as reactive oxygen-derived species (ROS), outweighs the strategy of antioxidant defenses, culminating in the interruption of signaling and redox control. It has been suggested that Cd increases ROS mainly by inducing damage to the electron transport chain and by increasing the activity of nicotinamide adenine dinucleotide hydrogen phosphate (NADPH) oxidase (NOX) and the concentration of free iron (Fe), as well as causing a decrease in antioxidant defense. On the other hand, OS has been related to changes in the biology of the epigenome, causing adverse health effects. Recent studies show that Cd generates alterations in deoxyribonucleic acid (DNA) methylation, histone modifications, and noncoding RNA (ncRNA) expression. However, the role of OS in Cd-induced epigenetic modifications is still poorly explored. Therefore, this review provides an update on the basic concepts of OS and its relationship with Cd-induced epigenetic changes. Furthermore, the use of antioxidant compounds is proposed to mitigate Cd-induced epigenetic alterations.

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Section: Dna Methylationmentioning

confidence: 53%

Oxidative Stress and Its Role in Cd-Induced Epigenetic Modifications: Use of Antioxidants as a Possible Preventive Strategy

Hernández-Cruz

Arancibia-Hernández

Loyola-Mondragón

et al. 2022

Oxygen

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“…On the other side, the induction of IGFI may be caused by the role of IGFI as a local regulator of fish spermatogenesis 80 . Likewise, Hu et al 60 reported that the long-term exposure of Oreochromis niloticus to Cd dramatically lowered body length and weight and downregulated hepatic mRNA levels of IGFI, IGFII, and GHRs. Furthermore, Zebral et al 81 reported that long-term copper (Cu2 +) exposure in the fish Poecilia vivipara, Teleostei Poeciliidae, resulted in muscle growth hormone insensitivity and decreased muscular IGFI and IGFII mRNA expression.…”

Section: Discussionmentioning

confidence: 95%

“…It is well established that changes in gene expression, specifically in fish, play a pivotal role as bioindicators of heavy metal pollution 11,[58][59][60][61] . In this context, the observed alteration in gene expression of genes correlated with heavy metal detoxification, immune response, and growth performance in Nile tilapia during the current research could be used as bioindicators for the aquatic ecosystem health evaluation.…”

Section: Discussionmentioning

confidence: 99%

Gender-specific responses in gene expression of Nile tilapia (Oreochromis niloticus) to heavy metal pollution in different aquatic habitats

Awad,

Hemeda,

El Nahas

et al. 2024

Sci Rep

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Monitoring heavy metal accumulation is essential for assessing the viability of aquatic ecosystems. Our methodology involved integrating analysis of immunological, stress, inflammatory, and growth-related gene expression in male and female Nile tilapia with on-site recordings of physicochemical parameters. Additionally, we assessed the effect of different physicochemical parameters on heavy metal bioavailability and residual concentration in fish and water. Samples of fish and water were gathered from three different localities: Lake Brullus, a brackish lake sited in northern Egypt; Lake Nasser, an artificial freshwater reservoir located in southern Egypt; and El-Qanater El-Khayria, a middle-freshwater location belonging to the Rashid branch of the river Nile. The assessment of heavy metal residues (Fe, Cu, Zn, Mn, and Ni) revealed that their concentrations were higher in fish specimens compared to their counterparts in water (except for Ni). In addition, Lake Brullus emerges as the most polluted area, exhibiting elevated levels of heavy metals concentrations in water and fish specimens. In contrast, Lake Nasser showed the least degree of heavy metals pollution. Gene expression analysis revealed gender-specific responses to heavy metal exposure at the three investigated water bodies. The expression of hepatic antioxidant genes (GST and MT) and inflammatory-related genes (CC-chemokine and TNFα) increased in males compared to females. In females, the immune and pro-inflammatory-related genes (IgM and CXC2-chemokine) transcripts were upregulated. Additionally, growth-related genes were downregulated in both Lake Brullus and El-Qanater; on the contrary, fish samples from Lake Nasser exhibited a normal expression pattern of growth-related genes. Stress-related genes (HSP70 and HSP27) showed significant downregulation in gills of both genders from Lake Brullus. The minimal presence of heavy metal contaminants in Lake Nasser seems to endorse the normal patterns of gene expression across all gene categories. A potential gender-specific gene expression response towards pollution was noticed in genes associated with inflammation and antioxidant activities. This highlights the importance of considering gender-related responses in future environmental assessments.

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“…This may be due to cadmium exposure increasing reactive oxygen species levels in the body and interrupting DNA methylation [ 29 ]. In addition, global DNA methylation levels significantly decreased with increasing cadmium concentration and exposure time, possibly due to increased oxidative DNA damage and downregulated expression of DNA methyltransferases 3a and 3b [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Possible Combined Effects of Plasma Folate Levels, Global DNA Methylation, and Blood Cadmium Concentrations on Renal Cell Carcinoma

et al. 2023

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Epigenetic effects of environmental pollutants may be related to carcinogenesis. This study aimed to explore the association between the global DNA methylation marker: 5-methyl-2-deoxycytidine (5mdC) and renal cell carcinoma (RCC), and further investigated whether plasma folate and vitamin B12 levels and 5mdC modified the association between blood cadmium concentrations and RCC. We recruited 174 RCC patients and 673 non-RCC controls. Blood cadmium concentrations, plasma folate and vitamin B12 levels were measured. The amount of 5mdC in the DNA sample was expressed as percentages of the total cytosine content. An increase of 5mdC (%) and plasma folate and vitamin B12 levels were associated with decreasing odds ratio (OR) of RCC. Although plasma folate levels were not directly associated with 5mdC (%), a combined effect was observed with the odds of low plasma folate levels and low 5mdC (%) were greater among RCC patients compared to controls (OR (95% confidence interval, CI) = 11.86 (5.27–26.65)). Additionally, we observed that the odds of low plasma folate and high blood cadmium levels were greater among RCC patients than in controls (OR (95% CI): 8.15 (1.39–7.13)). This study provides suggestive evidence that plasma folate levels may modify the associations between 5mdC (%) or blood cadmium concentrations and RCC.

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Effects of long-term cadmium exposure on growth, antioxidant defense and DNA methylation in juvenile Nile tilapia (Oreochromis niloticus)

Cited by 19 publications

References 69 publications

Oxidative Stress and Its Role in Cd-Induced Epigenetic Modifications: Use of Antioxidants as a Possible Preventive Strategy

Oxidative Stress and Its Role in Cd-Induced Epigenetic Modifications: Use of Antioxidants as a Possible Preventive Strategy

Gender-specific responses in gene expression of Nile tilapia (Oreochromis niloticus) to heavy metal pollution in different aquatic habitats

Possible Combined Effects of Plasma Folate Levels, Global DNA Methylation, and Blood Cadmium Concentrations on Renal Cell Carcinoma

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