Effects of long-term antihypertensive treatment with lisinopril on resistance arteries in hypertensive patients with left ventricular hypertrophy

Rizzoni, Damiano; Muiesan, María Lorenza; Porteri, Enzo; Castellano, Maurizio; Zulli, Roberto; Bettoni, Giorgio; Salvetti, Massimo; Monteduro, Cristina; Agabiti‐Rosei, Enrico

doi:10.1097/00004872-199715020-00011

Cited by 102 publications

(68 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In patients with essential hypertension, treatment with cizalapril for 2 years and lisinopril for 3 years improved vascular responses to acetylcholine in the subcutaneous microcirculation 4,[116][117][118] . Furthermore, within the peripheral circulation, perindopril, ramipril, quinapril and the perindopril-indapamide combination improve flowmediated dilatation, which most likely relates to increased NO bioavailability and prevention of angiotensin-II induced oxidative stress 4,35,37,115,[119][120][121] .…”

Section: Ace Inhibitors and Angiotensin II Receptor Blockersmentioning

confidence: 99%

Drug Treatment of Hypertension: Focus on Vascular Health

Cameron

Lang

Touyz

2016

Drugs

View full text Add to dashboard Cite

Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart disease and renal failure. While many systems contribute to blood pressure elevation, the vascular system is particularly important, because vascular dysfunction is a cause and consequence of hypertension. Hypertension is characterised by a vascular phenotype of endothelial dysfunction, arterial remodelling, vascular inflammation and increased stiffness. Antihypertensive drugs that influence vascular changes associated with high blood pressure have greater efficacy for reducing cardiovascular risk than drugs that reduce blood pressure but have little or no effect on the adverse vascular phenotype. Angiotensin converting enzyme Key Points• Hypertension is characterized by a vascular phenotype of endothelial dysfunction and structural remodeling.• Anti-hypertensive drugs that target the vascular changes associated with hypertension appear to be most efficacious• New anti-hypertensive drugs should promote vascular health as well as reducing blood pressure 3

show abstract

Section: Ace Inhibitors and Angiotensin II Receptor Blockersmentioning

confidence: 99%

Drug Treatment of Hypertension: Focus on Vascular Health

Cameron

Lang

Touyz

2016

Drugs

View full text Add to dashboard Cite

show abstract

“…In fact, a linear relation between M/L of subcutaneous small resistance arteries and left ventricular mass index or relative wall thickness has been detected in hypertensive patients; this relation with left ventricular mass and geometry was more evident in patients with activation of the renin-angiotensinaldosterone system. 26 It is interesting to note that several studies have demonstrated that the effect of different antihypertensive drugs on vascular structure is not the same, being clearly more effective for those drugs that interfere with the renin-angiotensin system [27][28][29] and calcium antagonists 30 than for ␤-blockers.…”

Section: Rizzoni Et Al Prognostic Role Of Small-artery Structurementioning

confidence: 99%

Prognostic Significance of Small-Artery Structure in Hypertension

et al. 2003

Self Cite

View full text Add to dashboard Cite

Background-The presence of structural alterations in the microcirculation may be considered an important mechanism of organ damage; however, it is not currently known whether structural alterations of small arteries may predict fatal and nonfatal cardiovascular events. Methods and Results-One hundred twenty-eight patients were included in the present study. There were 59 patients with essential hypertension, 17 with pheochromocytoma, 20 with primary aldosteronism, 12 with renovascular hypertension, and 20 normotensive patients with non-insulin-dependent diabetes mellitus. All subjects were submitted to a biopsy of subcutaneous fat. Small resistance arteries were dissected and mounted on an isometric myograph, and the tunica media-to-internal lumen ratio (M/L) was measured. The subjects were reevaluated after an average follow-up time of 5.4 years. Thirty-seven subjects had a documented fatal or nonfatal cardiovascular event (5.32 events/100 patients per year). In the subcutaneous small arteries of subjects with cardiovascular events, a smaller internal diameter and a clearly greater M/L was observed. Our subjects were subdivided according to the presence of an M/L greater or smaller than the mean and median values observed in the whole population (0.098) or mean value ϩ2 SD of our normal subjects (0.11). Life-

show abstract

“…8 Similar results were obtained in a small number of patients with and without left ventricular hypertrophy. 9 Recently, we have investigated possible relationships between subcutaneous small resistance artery structure, and BP values in a population of more than 200 normotensive subjects and hypertensive patients. Among the most important predictors of small artery structure there were clinic SBP, DBP and mean BP, 24-h SBP and DBP, and the ratio between the PP and stroke volume, taken as an indirect index of large artery distensibility (Figure 1; D Rizzoni and E Agabiti-Rosei, unpublished data).…”

Section: Microvasculature and Hypertensive CV Riskmentioning

confidence: 99%

“…Some intervention studies have demonstrated an improvement or even an almost complete normalisation of the structure of subcutaneous small resistance arteries with angiotensin converting enzyme (ACE) inhibitors (cilazapril, perindopril (Per) and lisinopril), 9,16,17 calcium channel blockers (nifedipine, amlodipine and irsradipine) and 16,17 angiotensin II receptor blockers (losartan, irbesartan, candesartan and valsartan). [16][17][18] On the contrary, the b-blocker atenolol and the diuretic hydrochlorothiazide had lesser effects on resistance vessels and on brachial PP, despite a BP reduction similar to that observed with ACE inhibitors.…”

Section: Microvasculature and Chronic Anti-hypertensive Drug Therapymentioning

confidence: 99%

Macro and microvasculature in hypertension: therapeutic aspects

et al. 2008

View full text Add to dashboard Cite

Macrovasculature, microvasculature and the heart determine the structure and function of the circulatory system. Due to the viscoelastic properties of large arteries, the pulsatile pressure and flow that result from intermittent ventricular ejection is smoothed out, so that microvasculature mediates the delivery of nutrients and oxygen to tissues steadily. The disruption of this function, which occurs when microvascular structure develops in response to hypertension, leads to end-organ damage. Microvascular structure is not only the site of vascular resistance, but also the origin of most of the wave reflections generating increased central systolic blood pressure (SBP) in the elderly. Nowadays many data of the literature suggest that hypertension-related damage to the micro and macrovascular system may be manageable through pharmacological agents. Among them, b-blocking agents and diuretics poorly modify microvascular structure, whereas angiotensin and calcium entry blockade has an opposite effect, thereby reducing central wave reflections and, finally, causing a selective SBP reduction.

show abstract

Effects of long-term antihypertensive treatment with lisinopril on resistance arteries in hypertensive patients with left ventricular hypertrophy

Cited by 102 publications

References 27 publications

Drug Treatment of Hypertension: Focus on Vascular Health

Drug Treatment of Hypertension: Focus on Vascular Health

Prognostic Significance of Small-Artery Structure in Hypertension

Macro and microvasculature in hypertension: therapeutic aspects

Contact Info

Product

Resources

About