1984
DOI: 10.1111/j.1528-1157.1984.tb04154.x
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Effects of Long‐Term Antiepileptic Therapy on the Hypothalamic‐Pituitary Axis in Man

Abstract: Effects of long-term antiepileptic therapy on the hypothalamic-pituitary axis were evaluated from the basal and stimulated plasma levels of growth hormone (GH) and prolactin (PRL) and from circadian adrenocorticotropic hormone (ACTH)/cortisol rhythms. Data for patients with well-controlled epilepsy of mild-to-moderate severity were compared with those for normal healthy volunteers. Analysis of the effects of each antiepileptic drug (AED) and of combined AEDs revealed minor abnormalities of stimulated GH secret… Show more

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Cited by 79 publications
(37 citation statements)
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“…Therefore, a direct, inhibitory effect of AED treatment on 17a-hydroxyprogesterone synthesis in the adrenal cortex might explain our finding. Serum cortisol concentrations remained unchanged in both the men and women with epilepsy, a finding which is in accordance with those of other investigators (26,42).…”
Section: B Stoffel-wagner Et a Tsupporting
confidence: 82%
“…Therefore, a direct, inhibitory effect of AED treatment on 17a-hydroxyprogesterone synthesis in the adrenal cortex might explain our finding. Serum cortisol concentrations remained unchanged in both the men and women with epilepsy, a finding which is in accordance with those of other investigators (26,42).…”
Section: B Stoffel-wagner Et a Tsupporting
confidence: 82%
“…In contrast, phenobarbital treatment seemed to have no effect on the normal growth hormone plasma profiles secreted by adult control rats neonatally exposed to saline [20]. Relevant to these animal studies are clinical findings demonstrating that in utero exposure to phenobarbital [36] as well as long-term phenobarbital anticonvulsant therapy [37] can reduce the pulse amplitudes of plasma growth hormone in humans.…”
Section: Discussionmentioning
confidence: 99%
“…Prolactin is known to rise in sleep (20) (when most cases of SUDEP occur) and with some AEDs (21)(22)(23)(24)(25)(26)(27)(28). Although it is possible that the increase in prolactin in three patients, in whom there was no clinical evidence of a seizure, might have been caused by sleep-related increase (29), overall these factors do not seem to have had much effect on prolactin measurements in the SUDEP and the control groups with epilepsy.…”
Section: Discussionmentioning
confidence: 89%