Effects of long-term administration of clozapine on body weight and food intake in rats

Baptista, Trino; Mata, Alfredo; Teneud, Luis; Quijada, M. De; Han, Huiwan; Hernández, Luis

doi:10.1016/0091-3057(93)90084-7

Cited by 48 publications

(39 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antelman et al (1977) acutely administered CLO either directly into the brain (0.04-50 μg) or via gavage (10-20 mg/kg) and found dose-dependent increases in food intake regardless of route of administration. However, the majority of remaining studies investigating the effect of CLO showed no significant changes or even decreases in cumulative food intake and body weight in both male (Baptista et al 1993;Choi et al 2007;Galistu et al 2011;von Wilmsdorff et al 2010) and female rats (Albaugh et al 2006;Baptista et al 1993;Choi et al 2007;Cooper et al 2008a). One potential explanation for this discrepancy is the solubility constraints of chronic CLO administration; the desired drug concentration cannot be maintained in mini-pumps to allow delivery of therapeutic doses (Choi et al 2007;Kapur et al 2003).…”

Section: Clozapinementioning

confidence: 82%

Atypical antipsychotics and effects on feeding: from mice to men

et al. 2016

View full text Add to dashboard Cite

The findings from this review indicate that the varying levels of AAP-related weight gain reflect changes in both appetite and feeding behaviors, which differ by type of AAP. However, inconsistencies exist among the studies (both human and rodent) that may reflect considerable differences in study design and methodology. Future studies examining underlying mechanisms of antipsychotic-induced weight gain are recommended in order to develop strategies addressing the serious metabolic side effect of AAPs.

show abstract

Section: Clozapinementioning

confidence: 82%

Atypical antipsychotics and effects on feeding: from mice to men

et al. 2016

View full text Add to dashboard Cite

show abstract

“…For example, 30-day administration of sulpiride induces weight gain in female, but not male, rats (Baptista et al 1987). Chronic clozapine administration, however, in both male and female rats fails to increase food intake or weight gain (Baptista et al 1993).…”

Section: Introductionmentioning

confidence: 99%

Effects of clozapine, olanzapine and haloperidol on the microstructure of ingestive behaviour in the rat

2003

View full text Add to dashboard Cite

Clozapine and olanzapine increased fat intake whereas haloperidol did not, and this resembles the greater weight gain liability of atypical antipsychotics in humans. A delay or reduction of the post-ingestive satiety signal combined with preserved palatability appears to be the mechanism responsible for fat hyperphagia in rats treated with clozapine and olanzapine. Conversely, haloperidol leaves satiety unaffected but reduces the palatability of the fat emulsion resulting in reduced intake.

show abstract

“…A number of studies have investigated the effects of atypical antipsychotics on food intake and weight gain in rodents in order to develop an animal model of antipsychotics-induced obesity and insulin resistance (Baptista et al, 1993, Fadel et al, 2002Kaur et al, 2002;Lee et al, 2002;Pouzet et al, 2003). Remarkably, unlike humans, differences between clozapine-and olanzapine-induced effects have been reported in rats.…”

Section: Introductionmentioning

confidence: 99%

Effects of olanzapine on glucose transport, proliferation and survival in C2C12 myoblasts

Tulipano

Spano

2008

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

Please cite this article as: Tulipano, G., Spano, P.F., Cocchi, D., Effects of olanzapine on glucose transport, proliferation and survival in C2C12 myoblasts, Molecular and Cellular Endocrinology (2007), doi:10.1016/j.mce.2008 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. ABSTRACTThe aim of our study was to investigate the direct effects of atypical antipsychotics on muscle cell functions in order to ascertain the diabetic liability of these drugs. We investigated the effects of olanzapine, clozapine and -methyl-5-hydroxytryptamine on basal glucose uptake and glucose uptake in response to insulin using in vitro cultures of mouse skeletal muscle satellite cells (C2C12). We extended our study to the effects of these compounds on cell proliferation, survival and differentiation into myotubes and on the growth of differentiated myotubes. Olanzapine and -methyl-5-HT stimulated 2-deoxyglucose uptake in C2C12 myoblasts in a dose-dependent manner (minimal effective dose: 2 µM olanzapine and 10 µM -methyl-5-HT). The treatment with clozapine had no effect on glucose transport. Insulin and olanzapine increased the plasma membrane abundance of glucose transporter GLUT4. We investigated whether protein kinase Akt (PKB) and AMP-dependent kinase may partecipate in mediating olanzapine effects on glucose transport. Clozapine and olanzapine did not induce DNA laddering in differentiating myoblasts and differentiated myotubes and did not affect myotube growth. Olanzapine-induced glucose disposal in vitro is consistent with the acute lowering of plasma glucose/insulin concentrations that occurs in rats before olanzapine-induced overeating (Albaugh et al., 2006).

show abstract

Effects of long-term administration of clozapine on body weight and food intake in rats

Cited by 48 publications

References 21 publications

Atypical antipsychotics and effects on feeding: from mice to men

Atypical antipsychotics and effects on feeding: from mice to men

Effects of clozapine, olanzapine and haloperidol on the microstructure of ingestive behaviour in the rat

Effects of olanzapine on glucose transport, proliferation and survival in C2C12 myoblasts

Contact Info

Product

Resources

About