Effects of Long-Term Administration of Acetaminophen on the Nutritional Utilization of Dietary Protein

Abstract

The effect of long-term administration of acetaminophen to rats on the dietary protein utilization was investigated using protein-sufficient and protein-deficient diets. Fat digestibility, food efficiency and some hepatic parameters were also determined. Results showed that there was a significant decrease in the nitrogen metabolic utilization in the protein-sufficient treated animals compared to the untreated group (0.59 ± 0.03 vs. 0.75 ± 0.03, p < 0.001). The protein-deficient diet and the administration of the drug resulted in lower nitrogen metabolic utilization in either of the two metabolic balances (days 4–11 and 36–42). These changes were not accompanied by variations in the nitrogen digestibility coefficient.

Drugs–nutrient interactions: a potential problem during adolescence

“…In consequence, high ACAP intakes may make methionine less available for protein synthesis and methylation reactions. We have demonstrated in rats that longterm ACAP administration leads to a signi®cantly lower dietary protein metabolism when compared to the control group (Varela-Moreiras et al, 1991;Ragel Prudencio et al, 1994). In addition, when we fed rats for 4 weeks with aspirin or acetaminophen the treatments were not associated with important changes in total hepatic folate content or folate derivatives distribution.…”

Vitamin D deficiency and morbimortality in critically ill paediatric patients

“…A menor área corporal expuesta, menor síntesis de vitamina D 3 . La elección de la ropa, tanto el tipo de tejido como la cantidad, puede influir en los niveles séricos de vitamina D. sangre que las del norte (117) .…”