Effects of long non-coding RNA uc.245 on cardiomyocyte-like differentiation in P19 cells via FOG2

Liu, Heng; Hu, Yin; Yin, Jing; Yan, Xiangyun; Chen, Wenjuan; Wang, Xinyun; Han, Song; Yu, Zhangbin; Li, Mengmeng

doi:10.1016/j.gene.2018.12.080

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…Interestingly, although uc.245 has no direct effects on the cell cycle, it can play the same role as the ucRNAs discussed above by downregulating the expression of friend of GATA 2 (FOG2). In addition, the co-silencing of uc.245 and FOG2 can upregulate the expression of specific genes and proteins required for myocardial formation, thus promoting the differentiation of P19 cells into cardiomyocytes [ 12 ]. Similar to uc.167, a study found that uc.4 is located in the Casz1 gene region but is expressed independently of this gene.…”

Section: Physiologymentioning

confidence: 99%

Ultra-conserved RNA: a novel biological tool with diagnostic and therapeutic potential

Wang

2023

Discov Onc

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Ultra-conserved RNA (ucRNA) is a subset of long non-coding RNA, that is highly conserved among mice, rats and humans. UcRNA has attracted extensive attention in recent years for its potential biological significance in normal physiological function and diseases. However, due to the instability of RNA and the technical limitation, the function and mechanism of ucRNAs are largely unknown. Over the last two decades, researchers have made a lot of efforts to try to lift the veil of ucRNA in nervous, cardiovascular system and other systems as well as cancers. Since the concept of the glymphatic system is relatively new, we summarized here recent findings on the functions, regulation and the underlying mechanisms of ucRNAs in physiology and pathology. Meanwhile, pathology in some diseases is likely to contribute to abnormal expression of ucRNA in turn. We also discuss the technical challenges and bright prospects for future applications of ucRNAs in the diagnosis and treatment of diseases.

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Section: Physiologymentioning

confidence: 99%

Ultra-conserved RNA: a novel biological tool with diagnostic and therapeutic potential

Wang

2023

Discov Onc

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“…Additional evidence on functional role of lncRNAs during early cardiomyogenic lineage specification has been obtained only using in vitro systems. For example, uc.245 lncRNA over-expression downregulates the expression of several cardiomyogenic-specific molecular markers such as Nkx2.5, Gata4, Mef2c in P19 cells [ 132 , 133 ]. Similarly, uc.167 overexpression inhibits proliferation while promoting apoptosis in P19 cells and regulates Mef2c expression [ 134 ].…”

Section: Post-transcriptional Control Of Precardiac Mesoderm Formatio...mentioning

confidence: 99%

Post-Transcriptional Regulation of Molecular Determinants during Cardiogenesis

Lozano-Velasco

García-Padilla

Muñoz-Gallardo

et al. 2022

IJMS

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Cardiovascular development is initiated soon after gastrulation as bilateral precardiac mesoderm is progressively symmetrically determined at both sides of the developing embryo. The precardiac mesoderm subsequently fused at the embryonic midline constituting an embryonic linear heart tube. As development progress, the embryonic heart displays the first sign of left-right asymmetric morphology by the invariably rightward looping of the initial heart tube and prospective embryonic ventricular and atrial chambers emerged. As cardiac development progresses, the atrial and ventricular chambers enlarged and distinct left and right compartments emerge as consequence of the formation of the interatrial and interventricular septa, respectively. The last steps of cardiac morphogenesis are represented by the completion of atrial and ventricular septation, resulting in the configuration of a double circuitry with distinct systemic and pulmonary chambers, each of them with distinct inlets and outlets connections. Over the last decade, our understanding of the contribution of multiple growth factor signaling cascades such as Tgf-beta, Bmp and Wnt signaling as well as of transcriptional regulators to cardiac morphogenesis have greatly enlarged. Recently, a novel layer of complexity has emerged with the discovery of non-coding RNAs, particularly microRNAs and lncRNAs. Herein, we provide a state-of-the-art review of the contribution of non-coding RNAs during cardiac development. microRNAs and lncRNAs have been reported to functional modulate all stages of cardiac morphogenesis, spanning from lateral plate mesoderm formation to outflow tract septation, by modulating major growth factor signaling pathways as well as those transcriptional regulators involved in cardiac development.

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“…Other examples of lncRNAs that regulates CMs proliferation, differentiation and maturation includes uc. 40, uc.167, uc.245 and TUC40 [85][86][87][88].…”

Section: Chamber Formation and The Final Phases Of Heart Maturationmentioning

confidence: 99%

Comprehensive Overview of Non-coding RNAs in Cardiac Development

Pozzo

Chai

Sampaolesi

2020

Advances in Experimental Medicine and Biology

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Cardiac development in the human embryo is characterized by the interactions of several transcription and growth factors leading the heart from a primordial linear tube into a synchronous contractile four-chamber organ. Studies on cardiogenesis showed that cell proliferation, differentiation, fate specification and morphogenesis are spatiotemporally coordinated by cell-cell interactions and intracellular signalling cross-talks. In recent years, research has focused on a class of inter-and intra-cellular modulators called non-coding RNAs (ncRNAs), transcribed from the noncoding portion of the DNA and involved in the proper formation of the heart. In this chapter,we will summarize the current state of the art on the roles of three major forms of ncRNAs [microRNAs (miRNAs), long ncRNAs (lncRNAs) and circular RNAs (circRNAs)] in orchestrating the four sequential phases of cardiac organogenesis.

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Effects of long non-coding RNA uc.245 on cardiomyocyte-like differentiation in P19 cells via FOG2

Cited by 4 publications

References 31 publications

Ultra-conserved RNA: a novel biological tool with diagnostic and therapeutic potential

Ultra-conserved RNA: a novel biological tool with diagnostic and therapeutic potential

Post-Transcriptional Regulation of Molecular Determinants during Cardiogenesis

Comprehensive Overview of Non-coding RNAs in Cardiac Development

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