Effects of localized histamine microinjections into the hippocampal formation on the retrieval of a one-way active avoidance response in rats

Alvarez, Edgardo O.; Banzán, Arturo M.

doi:10.1007/bf01271557

Cited by 28 publications

(39 citation statements)

References 29 publications

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“…Animals may pass from compartment 2 (the punishment box) to compartment 1 (the safe box) through a swinging door that can be locked in its place. Rats were conditioned to escape through by opening the door after the ultrasonic sine-wave tone was on, as it was described in detail elsewhere (Alvarez and Banzan, 1995). Training sessions included 8 trials with a maximum duration of 4.5min each.…”

Section: Experimental Schedulementioning

confidence: 99%

“…Animals were anesthetized with ether and unilaterally implanted with guide steel cannulae (23-gauge, 15ram length) into the caudal ventral hippocampus, as it was described elsewhere (Alvarez and Banzan, 1990, 1995. After implantation rats were caged individually and remained at rest for at least 72h.…”

Section: Implantation Proceduresmentioning

confidence: 99%

“…Previous data have shown that this imidazolamine in HPC is able to selectively inhibit motor activity and exploration in rats Banzan, 1990, 1992). Recent results using the active avoidance response model and localized microinjections of HA into the ventral HPC showed that a significant deterioration of the conditioned response retrieval is evident in HA-treated rats (Alvarez and Banzan, 1995). Interestingly, these data suggest that HA may exert a negative modulatory effect on memory expression.…”

Section: Introductionmentioning

confidence: 95%

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Hippocampal histamine receptors: Possible role on the mechanisms of memory in the rat, II

Alvarez

Banzán

1996

J. Neural Transmission

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In this paper it was studied the role of histamine and histamine receptors in the hippocampus of rats on an active avoidance response induced by an ultrasonic tone. The animals had to learn to walk through a swinging door into a safe compartment only after the conditioning ultrasonic tone was on in order to avoid an electric shock to their feet. Trained animals were implanted in the ventral hippocampus with microinjection cannulae and injected twice with 1 microliter of saline solution containing pyrilamine (PYR, H1-HA antagonist), ranitidine (RAN, H2-HA antagonist) or histamine. The histamine antagonists were applied in a dose of 65.5 nmol each while histamine was administered in a dose of 45 nmol. The two variables measured were the time in sec the rats take to present the conditioned avoidance response and the accumulated percentage of conditioned avoidance response (CAR). Results showed that histamine administration significantly increased the latency time to escape and decreased the % CAR. These effects were not blocked by the administration of RAN. However, administration of PYR completely counteracted the HA effects. Present findings confirm our previous findings about the inhibitory effect of histamine on the hippocampal retrieval mechanisms and give further support to the hypothesis that HA acts on the memory processes in the hippocampal formation, by activation of H1-histamine receptors.

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Section: Experimental Schedulementioning

confidence: 99%

Section: Implantation Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

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Hippocampal histamine receptors: Possible role on the mechanisms of memory in the rat, II

Alvarez

Banzán

1996

J. Neural Transmission

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“…Rats treated with afluoromethylhistidine showed increased learning abilities in a maze paradigm, where they had to learn to avoid a foot shock [20]. Moreover, localized histamine injections into rat hippocampus prolonged significantly the latency time to escape in an active avoidance response [2]. Recently, the effects of lesions of the tuberomammillary nucleus on the performance of adult and aged rats in a set of cognitive tasks have been reported; in addition to a marked decrease in the number of histaminergic neurons, these lesions produced an improvement in every cognition test applied, and strongly diminished the age-related learning deficits [43].…”

Section: Histamine and Cognitionmentioning

confidence: 99%

Interactions between histaminergic and cholinergic systems in learning and memory

Bacciottini

Passani

Mannaioni

et al. 2001

Behavioural Brain Research

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The aim of this review is to survey biochemical, electrophysiological and behavioral evidence of the interactions between the cholinergic and histaminergic systems and evaluate their possible involvement in cognitive processes. The cholinergic system has long been implicated in cognition, and there is a plethora of data showing that cholinergic deficits parallel cognitive impairments in animal models and those accompanying neurodegenerative diseases or normal aging in humans. Several other neurotransmitters, though, are clearly implicated in cognitive processes and interact with the cholinergic system. The neuromodulatory effect that histamine exerts on acetylcholine release is complex and multifarious. There is clear evidence indicating that histamine controls the release of central acetylcholine (ACh) locally in the cortex and amygdala, and activating cholinergic neurones in the nucleus basalis magnocellularis (NBM) and the medial septal area-diagonal band that project to the cortex and to the hippocampus, respectively. Extensive experimental evidence supports the involvement of histamine in learning and memory and the procognitive effects of H 3 receptor antagonists. However, any attempt to strictly correlate cholinergic/histaminergic interactions with behavioral outcomes without taking into account the contribution of other neurotransmitter systems is illegitimate. Our understanding of the role of histamine in learning and memory is still at its dawn, but progresses are being made to the point of suggesting potential treatment strategies that may produce beneficial effects on neurodegenerative disorders associated with impaired cholinergic function.

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“…There is agreement that his- tamine and the histaminergic system have an important role in several physiological processes of the brain [6,[9][10][11] . Experimental data suggest that endogenous histamine plays an important role in learning and memory [12,13] .…”

Section: Introductionmentioning

confidence: 99%

Influence of Intracerebroventricular Administration of Histaminergic Drugs on Morphine State-Dependent Memory in the Step-Down Passive Avoidance Test

Zarrindast¹,

Khalilzadeh²,

Rezayat³

et al. 2005

Pharmacology

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The effects of histaminergic drugs on morphine state-dependent memory of a passive avoidance task were examined in mice. Pre-training administration of morphine (5 mg/kg) led to state-dependent learning with impaired memory recall on the test day which was reversed by pre-test administration of the same dose of the opioid. The pre-test intracerebroventricular (i.c.v.) administration of the H₁ blocker (pyrilamine) prevented the restoration of memory by morphine. The H₂ blocker (ranitidine) was ineffective in this regard and the H₃ blocker (clobenpropit) potentiated the effect of morphine on memory recall. The pre-test i.c.v. administration of histamine alone (5, 10, and 20 µg/mouse) not only mimicked the effect of pre-test morphine treatment, but also increased this action of the opioid. The effect of histamine on memory recall was not changed by the pre-test administration of µ-opioid receptor antagonist, naloxone. In conclusion, the improvement of memory recall by morphine treatment, on the test day, seems to be, at least in part, through the release of histamine followed by the stimulation of H₁ receptors. Histamine by itself, when administered on the test day, mimicked morphine-induced memory improvement by a mechanism independent of the µ-opioid receptors.

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Effects of localized histamine microinjections into the hippocampal formation on the retrieval of a one-way active avoidance response in rats

Cited by 28 publications

References 29 publications

Hippocampal histamine receptors: Possible role on the mechanisms of memory in the rat, II

Hippocampal histamine receptors: Possible role on the mechanisms of memory in the rat, II

Interactions between histaminergic and cholinergic systems in learning and memory

Influence of Intracerebroventricular Administration of Histaminergic Drugs on Morphine State-Dependent Memory in the Step-Down Passive Avoidance Test

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