Effects of Local Use of Insulin on Wound Healing in Non-diabetic Patients

Martínez-Jiménez, Mario Aurelio; Valadez-Castillo, Francisco Javier; Aguilar-García, Jorge; Ramírez-GarcíaLuna, José Luis; Gaitan-Gaona, Francisco; Pierdant-Pérez, Mauricio; Valdés‐Rodríguez, Rodrigo; Sánchez-Aguilar, Jesús Martín

doi:10.1177/2292550317740688

Cited by 19 publications

(25 citation statements)

References 19 publications

(28 reference statements)

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“…Five years later, Martinez's group conducted a similar study in 10 patients with full-thickness acute wounds. 40 A significant difference in new vessel growth was observed in the insulin-treated site, compared to the saline-treated site; however, there was no significant difference in fibrosis percentage between the two zones.…”

Section: Clinical Studiesmentioning

confidence: 84%

<p>Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences</p>

Wang

2020

DMSO

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Wound healing is a complex biological process that repairs damaged tissues and restores skin integrity. Insulin, a potent factor of wound healing, has been reported for nearly a century to induce rapid recovery of various wounds, as shown by numerous human and animal studies. Although many studies have addressed the healing effect of systemic insulin on burn wound, only few have investigated the efficacy of topical insulin. Thus, this study aimed to review evidence of the effects of topical insulin on wound healing, including on diabetic and non-diabetic wounds. The presented animal and clinical studies support that topical insulin improves wound healing through several mechanisms without causing side effects. Additionally, various wound dressings accelerate the wound healing with controlled and sustained delivery of bioactive insulin. Therefore, topical insulin has been appreciated in field of wound healing, and further studies are needed to improve our understanding of the role of insulin in the healing of various wounds.

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Section: Clinical Studiesmentioning

confidence: 84%

<p>Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences</p>

Wang

2020

DMSO

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“…For these reasons, measurement of the thermal asymmetry between a target and a control region is required to control for these factors. Temperature asymmetry has previously been used to identify skin inflammatory conditions, 23 breast cancer, 24 systemic inflammatory diseases, 25 septic shock, 26 and the healing potential of wounds 27‐29 . Our past research demonstrates, for example, that temperature asymmetries as low as 0.35°C can be used to discriminate between patients with and without appendicitis with the same level of accuracy as ultrasound evaluations 9 .…”

Section: Discussionmentioning

confidence: 98%

Diagnostic accuracy of infrared thermal imaging for detecting COVID‐19 infection in minimally symptomatic patients

Martínez-Jiménez

Loza-Gonzalez²,

Kolosovas-Machuca

et al. 2020

Eur J Clin Investigation

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Introduction Despite being widely used as a screening tool, a rigorous scientific evaluation of infrared thermography for the diagnosis of minimally symptomatic patients suspected of having COVID‐19 infection has not been performed. Methods A consecutive sample of 60 adult individuals with a history of close contact with COVID‐19 infected individuals and mild respiratory symptoms for less than 7 days and 20 confirmed COVID‐19 negative healthy volunteers were enrolled in the study. Infrared thermograms of the face were obtained with a mobile camera, and RT‐PCR was used as the reference standard test to diagnose COVID‐19 infection. Temperature values and distribution of the face of healthy volunteers and patients with and without COVID‐19 infection were then compared. Results Thirty‐four patients had an RT‐PCR confirmed diagnosis of COVID‐19 and 26 had negative test results. The temperature asymmetry between the lacrimal caruncles and the forehead was significantly higher in COVID‐19 positive individuals. Through a random forest analysis, a cut‐off value of 0.55°C was found to discriminate with an 82% accuracy between patients with and without COVID‐19 confirmed infection. Conclusions Among adults with a history of COVID‐19 exposure and mild respiratory symptoms, a temperature asymmetry of ≥ 0.55°C between the lacrimal caruncle and the forehead is highly suggestive of COVID‐19 infection. This finding questions the widespread use of the measurement of absolute temperature values of the forehead as a COVID‐19 screening tool.

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“…In the field of venous pathology, infrared thermography has been used to assess wound healing, response to treatment, and predict infection in patients with venous ulcers in a similar manner to patients with diabetic ulcers ( Martínez-Jiménez et al, 2013 , 2018b ; Dini et al, 2015 ; Cwajda-Białasik et al, 2020 ). Finally, infrared thermography has also been used to predict fistula maturation in a cohort of 100 patients with end-stage renal disease who needed vascular access for hemodialysis ( Al Shakarchi et al, 2017 ).…”

Section: Clinical Utilitymentioning

confidence: 99%

Infrared Thermography in Wound Care, Surgery, and Sports Medicine: A Review

Ramírez-GarcíaLuna

Bartlett²,

Arriaga-Caballero³

et al. 2022

Front. Physiol.

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For many years, the role of thermometry was limited to systemic (core body temperature) measurements (e.g., pulmonary catheter) or its approximation using skin/mucosa (e.g., axillary, oral, or rectal) temperature measurements. With recent advances in material science and technology, thermal measurements went beyond core body temperature measurements and found their way in many medical specialties. The article consists of two primary parts. In the first part we overviewed current clinical thermal measurement technologies across two dimensions: (a) direct vs. indirect and (b) single-point vs. multiple-point temperature measurements. In the second part, we focus primarily on clinical applications in wound care, surgery, and sports medicine. The primary focus here is the thermographic imaging modality. However, other thermal modalities are included where relevant for these clinical applications. The literature review identified two primary use scenarios for thermographic imaging: inflammation-based and perfusion-based. These scenarios rely on local (topical) temperature measurements, which are different from systemic (core body temperature) measurements. Quantifying these types of diseases benefits from thermographic imaging of an area in contrast to single-point measurements. The wide adoption of the technology would be accelerated by larger studies supporting the clinical utility of thermography.

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Effects of Local Use of Insulin on Wound Healing in Non-diabetic Patients

Abstract: We suggest that local insulin administration is a safe therapeutic option for angiogenesis in wounds of non-diabetic patients.

Cited by 19 publications

References 19 publications

<p>Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences</p>

<p>Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences</p>

Diagnostic accuracy of infrared thermal imaging for detecting COVID‐19 infection in minimally symptomatic patients

Infrared Thermography in Wound Care, Surgery, and Sports Medicine: A Review

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