Effects of Lithium on Inflammation

Nassar, Ahmad; Azab, Abed N.

doi:10.1021/cn500038f

Cited by 173 publications

(141 citation statements)

References 142 publications

(364 reference statements)

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“…[14][15][16][17][18][19] Moreover, a large body of data implies that inhibition of inflammation may contribute to the therapeutic effects of psychotropic drugs. [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] However, it is important to emphasize that many studies reported opposite findings; namely, that psychotropic drugs also exhibit pro-inflammatory effects. 10,31,[38][39][40][41] Furthermore, the mechanism underlying the anti-inflammatory properties of psychotropic drugs is not fully understood and it is not known whether their influence on inflammation contributes to their therapeutic and toxic effects.…”

Section: Introductionmentioning

confidence: 99%

Effects of olanzapine on LPS-induced inflammation in rat primary glia cells

Faour-Nmarne

Azab

2015

Innate Immun

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Olanzapine (OLZ) is an atypical antipsychotic drug that also has mood-stabilizing effects. The mechanism of action of OLZ is not fully understood. Accumulating data suggest that inflammation plays a role in the pathophysiology of mental disorders and that psychotropic drugs exhibit some anti-inflammatory properties. This study was undertaken to examine the effects of OLZ on LPS-induced inflammation in rat primary glia cells. Glia cells were extracted from newborn rat brains. OLZ (1 or 50 mM) was added to culture medium at 6 or 72 h before addition of LPS for another 18 h, and levels of IL-10, prostaglandin (PG) E 2 , NO and TNF-a, and expression of cyclo-oxygensase (COX)-2 and inducible NO synthase (iNOS) were determined. Treatment with 50 mM OLZ (but not 1 mM) significantly decreased LPS-induced secretion of IL-10, PGE 2 and TNF-a. In contrast, 50 mM OLZ significantly increased NO levels. OLZ did not alter the expression of COX-2 or iNOS in LPS-treated cells. These results suggest that OLZ differently affects the secretion of inflammatory mediators. Most of the significant effects of OLZ were obtained when 50 mM was used, which is a high and probably therapeutically irrelevant concentration. Therefore, under the conditions used in the present study OLZ seemed to lack a potent anti-inflammatory effect.

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Section: Introductionmentioning

confidence: 99%

Effects of olanzapine on LPS-induced inflammation in rat primary glia cells

Faour-Nmarne

Azab

2015

Innate Immun

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“…The effect of lithium on FGF23 expression may thus be considered a side effect unrelated to the antidepressant activity of the drug [105]. The observed effect of lithium may, for instance, contribute to the known impact of lithium on inflammation [106]. However, 1,25(OH) 2 D 3 has been shown to be a powerful regulator of mood [107][108][109] and the influence on FGF23 may indirectly modify the neurobiological effects of lithium.…”

Section: Discussionmentioning

confidence: 99%

Lithium- Sensitive Store-Operated Ca<sup>2+</sup> Entry in the Regulation of FGF23 Release

Zhang

Yan²,

Schmidt³

et al. 2015

Neurosignals

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Background/Aims: Lithium, a widely used drug for the treatment of mood disorders, has previously been shown to stimulate the release of fibroblast growth factor FGF23, a powerful regulator of 1,25(OH) 2 ] i following store depletion by inhibition of the sarcoendoplasmatic Ca 2+ ATPase (SERCA) with thapsigargin (1 µM). Results: SOCE in UMR106 cells was enhanced by lithium treatment, an effect abrogated by Orai1 inhibitor 2-APB (50 µM). FGF23 transcript levels were increased by lithium and inhibited by Orai1 inhibitors 2-APB (50 µM) and YM58483 (100 nM) as well as NF-κB inhibitors wogonin (100 µM) and withaferin A (500 nM). Moreover, Orai1 transcript levels were up-regulated by lithium, an effect attenuated by wogonin and withaferin A. Conclusion: Lithium stimulates FGF23 release at least in part by NF-κB dependent up-regulation of Orai1 transcription and store operated Ca 2+ entry.

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“…Litijum takođe ispoljava značajno anti-inflamatorno dejstvo, verovatno putem supresije COX-2 ekspresije kao i putem inhibicije stvaranja citokina IL-1β ili TNF-α i putem povećanja sinteze IL-2 i IL-10. (11,12). Moguće je da su promene u jedru u našoj studiji indukovane nekim od signalnih puteva na koje litijum utiče u ćelijama poput G protein /ciklični AMP ili inozitol 3 fosfatnog puta.…”

Section: Diskusijaunclassified

The influence of lithium sulphate on Shannon entropy in lymphocyte chromatin

Jeremić¹,

Pantić²,

Jakšić³

2018

Medicinski podmladak

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Introduction: Lithium affects numerous signal pathways in cells, which may ultimately lead to either increased or decreased gene expression in cell nuclei. However, effects of lithium on higher level of gene organization in the nuclei, like chromatin, is still poorly understood.Aim: To investigate the effects of lithium on chromatin organization in the nuclei of lymphocytes by investigating changes in Shannon entropy of chromatin in these cells.Material and Methods: Peripheral blood was treated with lithium sulphate until lithium concentrations of 1mmol/l, 2 mmol/l i 3 mmol/l was not reached. The smears were fixed with methanol and stained by Felgen method for DNK visualization. Cells in the smear were treated with hydrochloric acid for 120 min. Schiff reagent was used for staining for 120 min and smear washing was done with 6 ml of 10% of water solution of natrium metabisulfite. After staining, digital micrographs for each of the most representative sample of 30 lymphocytic chromatin structures were made. Shannon entropy was calculated by converting micrograph in the format of textual numerical string. Lymphocyte chromatin was also analyzed by textural method analysis.Results: Treatment with 1 mmol/l of lithium sulphate did not lead to a statistically significant increase in entropy values (p > 0.05). However, in samples where the concentration of lithium was 2 i 3 mmol/l, respectively, there was a statistically significant increase in entropy (p < 0.05). Also, a statistically significant and dose-dependent linear trend of an increase of chromatin entropy was detected in samples (p < 0.05). After lithium sulphate treatment, neither the mean value of angular second moment lymphocyte chromatin in control sample nor the inverse moment of the difference of treated lymphocytes changed (p > 0.05).Conclusion: Lithium sulphate in peripheral blood lymphocytes causes dose-dependent increase in Shannon chromatin entropy, which is not followed with similar changes in a textural chromatin parameters.

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Effects of Lithium on Inflammation

Cited by 173 publications

References 142 publications

Effects of olanzapine on LPS-induced inflammation in rat primary glia cells

Effects of olanzapine on LPS-induced inflammation in rat primary glia cells

Lithium- Sensitive Store-Operated Ca<sup>2+</sup> Entry in the Regulation of FGF23 Release

The influence of lithium sulphate on Shannon entropy in lymphocyte chromatin

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