Effects of lithium and haloperidol on human sperm motility in-vitro

Abstract

Two psychotropic drugs, lithium and haloperidol, were evaluated for their in-vitro effects on sperm motility using a transmembrane migration method. Sperm motility was measured either immediately after semen had been mixed with the drug or after a 2 h incubation period at 37 degrees C. Lithium inhibited human sperm motility in a dose-dependent manner with an EC50 of 10 mM when the semen-lithium mixture had been incubated. Sperm motility was increased to 127% of control when semen had been incubated with 0.027 microM haloperidol; this concentration was within the therapeutic range.

Phosphatidylinositol 3-kinase inhibition enhances human sperm motility

“…To investigate whether LY294002 could have a protective role toward loss of sperm motility in vitro, spermatozoa were treated with hydrogen peroxide (H 2 O 2 ) and lithium chloride (LiCl), two agents known to affect motility strongly in vitro (Shen et al, 1992;Griveau and Le Lannou, 1997). As expected, both agents significantly decreased sperm forward motility after 2 h treatment (Figure 5A,B) without affecting viability (not shown).…”