Effects of lisinopril and amlodipine on antioxidant status in experimental hypertension

Mantle, David; Patel, Vishal; Why, Howard; Ahmed, Saeed; Rahman, Inam U.; MacNee, William; Wassif, W; Richardson, PJ; Preedy, Victor R.

doi:10.1016/s0009-8981(00)00270-9

Cited by 19 publications

(8 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In accordance with our results, it was proved experimentally that the anti‐oxidant properties of lisinopril contributed to its beneficial effect in treating many clinical conditions, including renal fibrosis and cardiovascular complications 46,47 . Other studies were constructed to explore the exact mechanisms underlying the anti‐oxidant effect of lisinopril and they proved that it is a good scavenger of hydroxyl radicals and an iron chelators 11 .…”

Section: Discussionsupporting

confidence: 83%

“…In accordance with our results, it was proved experimentally that the anti-oxidant properties of lisinopril contributed to its beneficial effect in treating many clinical conditions, including renal fibrosis and cardiovascular complications. 46,47 Other studies were constructed to explore the exact mechanisms underlying the anti-oxidant effect of lisinopril and they proved that it is a good scavenger of hydroxyl radicals and an iron chelators. 11 Moreover, lisinopril was found to have a pronounced effect on lipid peroxidation and glutathione depletion in a guinea-pig isolated heart model of ischaemiareperfusion and trinitrobenzene sulphonic acid-induced colonic inflammation in rats.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Inhibition of the Renin–angiotensin System Attenuates the Development of Liver Fibrosis and Oxidative Stress in Rats

El‐Demerdash

Abdel-Salam²,

El-Batran³

et al. 2007

Clin Exp Pharma Physio

View full text Add to dashboard Cite

1. The present study was designed to investigate the potential antifibrotic and anti-oxidant effects of lisinopril, fosinopril and losartan in an experimental rat model of liver injury using carbon tetrachloride (CCl(4)). 2. First, the potential hepatoprotective dose of each drug was screened against CCl(4)-induced acute hepatotoxicity. Then, we chose the minimum hepatoprotective dose of each drug to further investigate the mechanisms involved in the hepatoprotection using a chronic model of hepatotoxicity induced by CCl(4). 3. Liver function was assessed in addition to histopathological examination. Furthermore, oxidative stress markers (reduced glutathione (GSH) and lipid peroxides levels) and markers of fibrosis (hydroxyproline content and liver fibrosis area) were assessed. 4. It was found that treatment of animals with different drugs concomitantly with CCl(4) significantly counteracted the changes in liver function induced by CCl(4) (except fosinopril). In addition, the drugs ameliorated the histopathological changes induced by CCl(4). All drugs significantly counteracted lipid peroxidation and GSH depletion (except fosinopril) compared with the CCl(4)-intoxicated group. Moreover, the drugs studied significantly reduced liver hydroxyproline levels and the area of fibrosis compared with the CCl(4)-intoxicated group. 5. In conclusion, the present study provides evidence for the hepatoprotective effect of lisinopril, fosinopril and losartan. Both lisinopril and losartan was found to have better hepatoprotective potential than fosinopril against CCl(4)-induced hepatotoxicity. These hepatoprotective effects can be explained on the basis of anti-oxidant and antifibrotic mechanisms, mainly enhancement of GSH and reduction of lipid peroxidation and fibrosis.

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Inhibition of the Renin–angiotensin System Attenuates the Development of Liver Fibrosis and Oxidative Stress in Rats

El‐Demerdash

Abdel-Salam²,

El-Batran³

et al. 2007

Clin Exp Pharma Physio

View full text Add to dashboard Cite

show abstract

“…In some studies, TAS is reported to be lower in SHR [48]. However, another study found no significant difference in TAS between SHR and WKY [49]. In our study, the reason for the increased TAS in control SHR still remains unclear.…”

Section: Resultscontrasting

confidence: 53%

Differential Responses to Blood Pressure and Oxidative Stress in Streptozotocin-Induced Diabetic Wistar-Kyoto Rats and Spontaneously Hypertensive Rats: Effects of Antioxidant (Honey) Treatment

Erejuwa

Sulaiman

Wahab

et al. 2011

IJMS

View full text Add to dashboard Cite

Oxidative stress is implicated in the pathogenesis and/or complications of hypertension and/or diabetes mellitus. A combination of these disorders increases the risk of developing cardiovascular events. This study investigated the effects of streptozotocin (60 mg/kg; ip)-induced diabetes on blood pressure, oxidative stress and effects of honey on these parameters in the kidneys of streptozotocin-induced diabetic Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). Diabetic WKY and SHR were randomized into four groups and received distilled water (0.5 mL) and honey (1.0 g/kg) orally once daily for three weeks. Control SHR had reduced malondialdehyde (MDA) and increased systolic blood pressure (SBP), catalase (CAT) activity, and total antioxidant status (TAS). SBP, activities of glutathione peroxidase (GPx) and glutathione reductase (GR) were elevated while TAS was reduced in diabetic WKY. In contrast, SBP, TAS, activities of GPx and GR were reduced in diabetic SHR. Antioxidant (honey) treatment further reduced SBP in diabetic SHR but not in diabetic WKY. It also increased TAS, GSH, reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio, activities of GPx and GR in diabetic SHR. These data suggest that differences in types, severity, and complications of diseases as well as strains may influence responses to blood pressure and oxidative stress.

show abstract

“…Similar results were obtained by Digiesi et al [24]. The studies on rats conducted by Mantle et al showed no changes in total antioxidant capacity [34]. There were no changes in total antioxidant capacity of plasma that indicated any impact of hypertension on the changes in the antioxidant system in plasma.…”

Section: Discussionsupporting

confidence: 85%

Disorders of erythrocyte structure and function in hypertensive patients

et al. 2012

View full text Add to dashboard Cite

SummaryBackgroundThe prevalence of hypertension is growing at an alarming rate. Increasing attention is being focussed on the oxidative stress accompanying this disease. In this study we examined the impact of this disease on some parameters of erythrocytes and human blood plasma.Material/MethodsWe examined the impact of hypertension on some parameters of erythrocytes and human plasma. The study involved 13 patients with hypertension and 19 healthy subjects. We determined lipid peroxidation, SH groups concentration, antioxidants enzymes activity, ATPase activity, total antioxidant capacity, total cholesterol level and erythrocyte membrane fluidity.ResultsWe found an increased level of lipid peroxidation and the concentration of SH groups in membrane proteins in patients with hypertension, and a decrease in the activity of catalase and superoxide dysmutase. No changes were observed in glutathione peroxidase and ATPase activity, level of total antioxidant capacity, total cholesterol level and fluidity of erythrocyte membranes.ConclusionsThese results suggest the existence of an impaired oxidative balance in hypertensive human erythrocytes.

show abstract

Effects of lisinopril and amlodipine on antioxidant status in experimental hypertension

Cited by 19 publications

References 34 publications

Inhibition of the Renin–angiotensin System Attenuates the Development of Liver Fibrosis and Oxidative Stress in Rats

Inhibition of the Renin–angiotensin System Attenuates the Development of Liver Fibrosis and Oxidative Stress in Rats

Differential Responses to Blood Pressure and Oxidative Stress in Streptozotocin-Induced Diabetic Wistar-Kyoto Rats and Spontaneously Hypertensive Rats: Effects of Antioxidant (Honey) Treatment

Disorders of erythrocyte structure and function in hypertensive patients

Contact Info

Product

Resources

About