Effects of lipotropic substances on the cholesterol content of the serum of rats

Ridout, Jessie H.; Patterson, Jean M.; Lucas, Christophe; Best, C. H.

doi:10.1042/bj0580306

Cited by 22 publications

(6 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On reintroduction of choline into the diet, the lipids of these fractions returned toward the normal levels. These findings are in general agreement with those reported earlier by us (1) and also Rosenfeld and Lang (30), for total plasma triacylglycerols and phospholipids, and Ridout, et al, (2) for total plasma cholesterol esters in early choline deficiency. Table I gives the recoveries of phosphorus in the various choline containing phospholipids isolated from the plasma lipoproteins.…”

Section: Analysis Of Neutral Lipidssupporting

confidence: 93%

“…Deprivation of dietary choline has been shown to result in a significant fall in total plasma phosphatidyl choline and triacylglycerols (1), cholesteryl esters, and total phospholipids (2,3), as well as in an impairment of secretion of plasma lipoproteins by the rat liver (4-6) and intestine (7). In addition, omission of dietary choline has been observed (8) to lead to a significant increase in hepatic synthesis of fatty acids, which is manifested in the formation of triacylglycerols of increased content of palmitic acid.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lipid profiles of plasma lipoproteins of fasted and fed normal and choline‐deficient rats

Mookerjea

Park

Kuksis

1975

Lipids

View full text Add to dashboard Cite

Three major density classes of lipoproteins and a residual protein (d greater than 1.21) were isolated by ultracentrifugation from plasma of fasted, fed normal, and choline-deficient rats. Lipid extracts were obtained from total plasma and the various density classes of lipoproteins, and each extract was examined in detail by thin layer and gas chromatographies. The results indicated essentially identical compositions of molecular species of phosphatidyl choline, which suggested their rapid equilibration among the different plasma lipoprotein classes. In contrast, the molecular species of the triacylglycerols and cholesteryl esters showed significant differences among the chylomicrons, very low and low, and high density lipoproteins, which excluded the possibility of their ready equilibration in vivo. Omission of choline from diet resulted in a sharp and statistically significant decrease in all lipid components of the very low and low density lipoproteins with 2 days. After 10 days of choline deficiency, the lipid levels of chylomicrons and very low and low density lipoproteins were ca. one-half the levels found in the choline supplemented animals, and there were discernible distortions in their lipid composition. Reintroduction of choline led to a prompt return to normal levels and lipid composition of both chylomicron and very low and low density lipoprotein fractions. The lack of equilibration of the triacylglycerols among the lipoprotein classes under normal conditions and in choline deficiency demonstrates an as yet unrecgnized source of compartmentation of plasma lipids.

show abstract

Section: Analysis Of Neutral Lipidssupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Lipid profiles of plasma lipoproteins of fasted and fed normal and choline‐deficient rats

Mookerjea

Park

Kuksis

1975

Lipids

View full text Add to dashboard Cite

show abstract

“…This is particularly true if choline deficiency is also imposed. This was observed by McKibbon et al 23 in puppies, Mann et al 2G in Cebus monkeys, and Ridout et al 27 in rats. In man, monkey, dog and rat, therefore, protein deficiency possibly as it influences the availability of lipotropic factors, appears to result in hypocholesterolemia.…”

mentioning

confidence: 50%

Effect of Dietary Protein upon Fat Transport

Olson

1958

Diabetes

View full text Add to dashboard Cite

The influence of diet upon the transport of lipids within the mammalian organism has become an increasingly popular and important subject for study during the last few years because of the growing realization that the average concentration of plasma lipids resulting from a given mode of fat transport over a prolonged period of time bears a relationship to the rate of atherogenesis. Of the many constituents of the diet concerned with fat metabolism and fat transport, dietary fat has been singled out as the chief factor relating diet to sustained hyperlipemia and hypercholesterolemia and, as a presumed consequence, to atherosclerosis. The epidemiological studies of Keys and associates 1 relating dietary fat content to mortality from coronary heart disease in various populations have been criticized recently as showing no association 2 between these variables or showing a less impressive association between coronary artery disease and dietary fat intake than with other dietary constituents, particularly animal protein. 2 " 4 It is my purpose to review the experimental and clinical evidence that protein, particularly animal protein, plays a role in fat transport and may, in certain ranges of intake, play a critical role in determining postabsorptive serum lipid concentrations.LIPID TRANSPORT Before we undertake a discussion of the effect of protein upon fat transport, I should like to review very briefly our current concepts of fat transport as they relate to the function of three organs primarily concerned with this process, i.e., the gut, the liver and the fat depots. The level of serum lipids in the mammal under various conditions of diet and metabolic state reflect principally the interaction of these organs in accomplishing the addition of lipid to or removal of lipid from the plasma compartment. In addition, it is probable that dietary and metabolic factors, including, of course, those operative in diabetes mellitus, exert their influence upon fat transport by modifying the function of one or more of Presented at the Symposium on Fat and Diabetes sponsored

show abstract

“…The increase in the plasma cholesterol level by PC might be attributable to the choline moiety of PC since diets containing adequate or more choline chloride lead to higher levels of plasma or serum cholesterol as compared with choline-deficient diets in rats fed cholesterol-free (4) and cholesterol-enriched (3,5,7,8) diets, and since PC can serve as a dietary source of choline (26). The increase in the plasma cholesterol level by dietary choline might be accounted for by the so-called lipotropic action of choline as judged from the parallel fluctuation of plasma cholesterol and phospholipid in rats fed a high cholesterol diet containing varying levels of choline chloride or methionine (8).…”

Section: Discussionmentioning

confidence: 99%

Comparative effects of choline chloride and phosphatidycholine on plasma and liver lipid levels in rats fed a choline-deficient high cholesterol diet.

Sugiyama

Mochizuki

Muramatsu

1987

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

View full text Add to dashboard Cite

SummaryThe effects of dietary choline chloride and phosphatidyl choline (PC) on plasma and liver lipid levels were investigated with rats fed a choline-deficient high cholesterol diet. The plasma cholesterol level significantly increased as the dietary level of choline chloride was in creased. The addition of PC to the choline-free diet also resulted in an increase in the plasma cholesterol level, but the magnitude of the increase was significantly lower than that by choline chloride. There was no difference, on the other hand, in the effect of choline chloride and PC on the plasma triglyceride level. The contents of cholesterol and triglyceride in the liver markedly decreased in rats fed a diet containing PC at a high level. The fecal excretion of neutral sterol significantly increased by the addition of PC at a high level, but not at a low level. The results indicate that the plasma cholesterol level, but not triglyceride, is differentially influenced by dietary choline chloride and PC, and that PC has both hyper and antihypercholesterolemic effects when compared with a choline-free diet and a diet supplemented with choline chloride, respec tively.

show abstract

Effects of lipotropic substances on the cholesterol content of the serum of rats

Cited by 22 publications

References 20 publications

Lipid profiles of plasma lipoproteins of fasted and fed normal and choline‐deficient rats

Lipid profiles of plasma lipoproteins of fasted and fed normal and choline‐deficient rats

Effect of Dietary Protein upon Fat Transport

Comparative effects of choline chloride and phosphatidycholine on plasma and liver lipid levels in rats fed a choline-deficient high cholesterol diet.

Contact Info

Product

Resources

About