Effects of lipopolysaccharide on the radiation-induced changes in the blood–brain barrier and the astrocytes

Kaya, Mehmet; Palandüz, Ayşe; Kalayci, Rivaze; Kemikler, Gönül; Şimşek, Gönül; Bılgıç, Bilge; Ahıshalı, Bülent; Arıcan, Nadir; Kocyildiz, Zuhal Celebi; Elmas, İmdat; Küçük, Mutlu; Karadeniz, Ahmet

doi:10.1016/j.brainres.2004.05.102

Cited by 43 publications

(36 citation statements)

References 42 publications

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“…The supernatant was carefully transferred to a measure and its absorbance was measured at 620-nm wavelength against phosphate buffer. By using the values measured at the spectrophotometer and Evans-blue absorbance amount regression curve, the amount was calculated on the computer per mg/100 g of brain tissue [9].…”

Section: Methodsmentioning

confidence: 99%

Gender Difference in the Influence of Antioxidants on the Blood–Brain Barrier Permeability During Pentylenetetrazol-Induced Seizures in Hyperthermic Rat Pups

Öztaş

Akgul

Seker

2007

Biol Trace Elem Res

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Our purpose in this study was to investigate the protective effects of selenium and vitamin E on the blood-brain barrier (BBB) permeability in rats with convulsion under hyperthermic conditions. To eliminate the effect of sex on BBB, we performed our study on 4- to 5-week-old prepubertal rat pups. Evans-blue was used as a BBB tracer. Convulsions were induced by administration of i.p. pentylenetetrazol. In the selenium group, 4 ppm selenium was added to the drinking water for 4-5 weeks. Vitamin E was administered at 700 mg/kg ip. It was shown that the convulsions, both under normothermic and hyperthermic conditions, caused widespread increase in the BBB permeability (p < 0.05). In addition, a significant difference was observed among female and male rats (f [1, 102] = 6.387, p < 0.05). In convulsions under normothermic conditions, there was a further increase in the BBB permeability (F[3, 102] = 43.534, p < 0.001) and a greater increase of permeability in males compared to females (F[1, 102] = 6.387, p < 0.05). Selenium and vitamin E significantly decreased the BBB destruction caused by convulsions under hyperthermic conditions in males (p < 0.05). Treatment with selenium or vitamin E has beneficial effects on the BBB breakdown during convulsions. But gender differences are very important in BBB permeability under pathological conditions and antioxidant treatments.

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Section: Methodsmentioning

confidence: 99%

Gender Difference in the Influence of Antioxidants on the Blood–Brain Barrier Permeability During Pentylenetetrazol-Induced Seizures in Hyperthermic Rat Pups

Öztaş

Akgul

Seker

2007

Biol Trace Elem Res

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“…First, lethal irradiation could have significant influences on the CNS tissue. Indeed, it had been reported that irradiation affects the integrity of the BBB (Diserbo et al, 2002;Yuan et al, 2003) and the expression of tight junction proteins (Kaya et al, 2004), and also induced apoptosis of endothelial cells (Li et al, 2004). An alternative explanation could have been the injection of BM cells by which myeloid precursors gain nonphysiological access to the circulation and thereby facilitate phagocyte generation from the blood stream.…”

Section: The Other Side Of the Coin: Microglia During Adulthoodmentioning

confidence: 99%

Microglia in the CNS: Immigrants from another world

Prinz

Mildner

2010

Glia

207

159

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Microglia are immunocompetent cells of the brain that continuously survey their environment with highly motile extensions. Although first described almost a century ago, the developmental origin of microglia is still debated. Besides early myeolomonocytic cell populations that colonize the developing neuroectoderm already during embryogenesis, newly migrated myeloid cells are considered important disease modulators in the adult brain. Thus, understanding the mechanisms of myeloid cell recruitment from the periphery and their development into bone marrow-derived phagocytes in the adult brain is pivotal for manipulating immune cell entry into the CNS and potentially reducing disease burden. A major question is whether bone marrow-derived mononuclear phagocytes have similar features and fates as their endogenous counterparts. Significant advances in our understanding of microglia biology under physiological as well as under pathological conditions have been made in the last few years, especially by combining novel gene-targeting techniques that allow cell manipulation and trafficking analysis. These new aspects will be discussed in the present review. V V C

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“…The supernatant was carefully transferred to a cuvette and its absorbance was measured at 620 nm against phosphate buffer and compared to a standard regression curve for Evans blue. The amount was reported in mg per 100 g of brain tissue [20].…”

Section: Methodsmentioning

confidence: 99%

Lifelong Consumption of Sodium Selenite: Gender Differences on Blood–Brain Barrier Permeability in Convulsive, Hypoglycemic Rats

Seker

Akgul

Öztaş

2008

Biol Trace Elem Res

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The aim of this study was to compare the effects of hypoglycemia and induced convulsions on the blood-brain barrier permeability in rats with or without lifelong administration of sodium selenite. There is a significant decrease of the blood-brain barrier permeability in three brain regions of convulsive, hypoglycemic male rats treated with sodium selenite when compared to sex-matched untreated rats (p<0.05), but the decrease was not significant in female rats (p>0.05). The blood-brain barrier permeability of the left and right hemispheres of untreated, moderately hypoglycemic convulsive rats of both genders was better than their untreated counterparts (p<0.05). Our results suggest that moderate hypoglycemia and lifelong treatment with sodium selenite have a protective effect against blood-brain barrier permeability during convulsions and that the effects of sodium selenite are gender-dependent.

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Effects of lipopolysaccharide on the radiation-induced changes in the blood–brain barrier and the astrocytes

Cited by 43 publications

References 42 publications

Gender Difference in the Influence of Antioxidants on the Blood–Brain Barrier Permeability During Pentylenetetrazol-Induced Seizures in Hyperthermic Rat Pups

Gender Difference in the Influence of Antioxidants on the Blood–Brain Barrier Permeability During Pentylenetetrazol-Induced Seizures in Hyperthermic Rat Pups

Microglia in the CNS: Immigrants from another world

Lifelong Consumption of Sodium Selenite: Gender Differences on Blood–Brain Barrier Permeability in Convulsive, Hypoglycemic Rats

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