Effects of lipopolysaccharide on consolidation of partial learning in the Y-maze

Holden, John Michael; Overmier, J. Bruce; Cowan, Elizabeth Todd; Matthews, Lisa

doi:10.1007/bf02734171

Cited by 13 publications

(4 citation statements)

References 20 publications

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“…This was proven by Y maze where the percentage spontaneous alternations significantly decreased compared to normal mice. These results are in accordance with a study which showed that the injection of LPS had a disruptive effect on the ability of mice to learn the Y maze [33]. Using the Morris water maze task, LPS-treated mice took a longer time to reach the hidden platform than normal mice.…”

Section: Discussionsupporting

confidence: 91%

Evaluation of Plant Phenolic Metabolites as a Source of Alzheimer's Drug Leads

Hassaan

Handoussa

El‐Khatib

et al. 2014

BioMed Research International

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Epidemiological studies have proven an association between consumption of polyphenols and prevention of Alzheimer's disease, the most common form of dementia characterized by extracellular deposition of amyloid beta plaques. The aim of this study is pharmacological screening of the aqueous alcohol extract of Markhamia platycalyx leaves, Schotia brachypetala leaves and stalks, and piceatannol compared to aqueous alcohol extract of Camellia sinensis leaves as potential Alzheimer's disease drugs. LC-HRESI(-ve)-MSn was performed to identify phenolics' profile of Schotia brachypetala stalks aqueous alcohol extract and revealed ten phenolic compounds as first report: daidzein, naringin, procyanidin isomers, procyanidin dimer gallate, quercetin 3-O-rhamnoside, quercetin 3-O-glucuronide, quercetin hexose gallic acid, quercetin hexose protocatechuic acid, and ellagic acid. Alzheimer's disease was induced by a single intraperitoneal injection of LPS. Adult male Swiss albino mice were divided into groups of 8–10 mice each receiving treatment for six days. In vivo behavioral tests (Y maze and object recognition) and in vitro estimation of amyloid beta 42 by ELISA showed significant differences between results of treated and nontreated animals.

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Section: Discussionsupporting

confidence: 91%

Evaluation of Plant Phenolic Metabolites as a Source of Alzheimer's Drug Leads

Hassaan

Handoussa

El‐Khatib

et al. 2014

BioMed Research International

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“…2) induced increased expression of pro-inflammatory cytokines in the brain [92][93][94][95] . Circulating LPS and pro-inflammatory cytokines have been shown to disrupt learning and memory in animals [96][97][98][99] , but peripherally administered LPS in IL6-deficient animals did not result in cognitive defects, indicating the probable importance of IL6 in the development of cognitive impairment 100 . IL10 counteracts the production of IL6 by microglial cells 101 , and IL10-deficient animals show increased production of pro-inflammatory cytokines…”

Section: Cytokines and Fatigue Depression And Cognitive Impairmentmentioning

confidence: 99%

Cytokines and their relationship to the symptoms and outcome of cancer

et al. 2008

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Tumours contain immune cells and a network of pro- and anti-inflammatory cytokines, which collaborate in the development and progression of cancer. Cytokine profiles might prove to be prognostic. The systemic effects of pro-inflammatory cytokines are associated with fatigue, depression and cognitive impairment, and can affect quality of life before, during and after treatment. In people with advanced cancer, pro-inflammatory cytokines are additionally associated with anorexia and cachexia, pain, toxicity of treatment and resistance to treatment. However, physical activity might modify cytokine levels and decrease fatigue in patients with cancer, and might also improve their prognosis.

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“…Substantial data, from a spectrum of clinical settings, highlight links between peripheral inflammation and cognitive symptoms. For example, peripheral activation of the immune system by a subseptic dose of lipopolysaccharide (LPS) has been shown to increase cytokine expression within the brain at levels associated with learning and memory disruption in both models of disease and health . In healthy volunteers, LPS leads to increased levels of IL‐1, TNFα and IL‐6 resulting in impaired working memory and cognitive dysfunction .…”

Section: Neuroinflammation and Cognitive Dysfunctionmentioning

confidence: 99%

“…For example, peripheral activation of the immune system by a subseptic dose of lipopolysaccharide (LPS) has been shown to increase cytokine expression within the brain [96][97][98] at levels associated with learning and memory disruption in both models of disease and health. [99][100][101] In healthy volunteers, LPS leads to increased levels of IL-1, TNFa and IL-6 resulting in impaired working memory and cognitive dysfunction. 102 Similarly, increased peripheral inflammation has also been associated with gradual cognitive decline and the development of dementia in the elderly population.…”

Section: Neuroinflammation and Cognitive Dysfunctionmentioning

confidence: 99%

Cytokine‐mediated blood brain barrier disruption as a conduit for cancer/chemotherapy‐associated neurotoxicity and cognitive dysfunction

Wardill

Mander

Sebille

et al. 2016

Intl Journal of Cancer

123

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Publishing in a subscription based journal Accepted (peer-reviewed) VersionThe accepted version of an article is the version that incorporates all amendments made during the peer review process, but prior to the final published version (the Version of Record, which includes; copy and stylistic edits, online and print formatting, citation and other linking, deposit in abstracting and indexing services, and the addition of bibliographic and other material.Self-archiving of the accepted version is subject to an embargo period of 12-24 months. The embargo period is 12 months for scientific, technical, and medical (STM) journals and 24 months for social science and humanities (SSH) journals following publication of the final article.• the author's personal website • the author's company/institutional repository or archive • not for profit subject-based repositories such as PubMed Central Articles may be deposited into repositories on acceptance, but access to the article is subject to the embargo period. The version posted may not be updated or replaced with the final published version (the Version of Record). Authors may transmit, print and share copies of the accepted version with colleagues, provided that there is no systematic distribution, e.g. a posting on a listserve, network or automated delivery.There is no obligation upon authors to remove preprints posted to not for profit preprint servers prior to submission. and subsequent cognitive impairment. Emerging data now show detectable levels of some chemotherapeutic agents within the CNS, indicating potential disruption of blood brain barrier integrity or transport mechanisms. Blood brain barrier disruption is a key aspect of many neurocognitive disorders, particularly those characterised by a proinflammatory state. Importantly, many proinflammatory mediators able to modulate the blood brain barrier are generated by tissues and organs that are targets for chemotherapy-associated toxicities. This review therefore aims to explore the hypothesis that peripherally-derived inflammatory cytokines disrupt blood brain barrier permeability, thereby increasing direct access of chemotherapeutic agents into the CNS to facilitate neuroinflammation and central neurotoxicity. 60

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Effects of lipopolysaccharide on consolidation of partial learning in the Y-maze

Cited by 13 publications

References 20 publications

Evaluation of Plant Phenolic Metabolites as a Source of Alzheimer's Drug Leads

Evaluation of Plant Phenolic Metabolites as a Source of Alzheimer's Drug Leads

Cytokines and their relationship to the symptoms and outcome of cancer

Cytokine‐mediated blood brain barrier disruption as a conduit for cancer/chemotherapy‐associated neurotoxicity and cognitive dysfunction

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