Effects of Lipoic Acid on Acrylamide Induced Testicular Damage

Lebda, Mohamed A.; Gad, Shereen B.; Gaafar, Hossam

doi:10.5455/msm.2014.26.208-212

Cited by 50 publications

(35 citation statements)

References 31 publications

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“…In our study, treatment of rats with ACR increased MDA concentrations in both brain and testicular tissues compared to vehicle-treated rats. Consistent with our study, it was reported previously that treatment of rats with ACR significantly increases MDA levels in the nervous system 43,44,45 and the testes 36,46 . Treatment with MIN significantly decreased MDA concentrations in the brain and testicular tissues of ACR-treated rats indicating its antioxidant effects.…”

Section: Discussionsupporting

confidence: 93%

Minocycline protects against acrylamide-induced neurotoxicity and testicular damage in Sprague-Dawley rats

et al. 2020

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This study investigated the protective effects of minocycline against acrylamide (ACR)-induced neurotoxicity and testicular damage in Sprague-Dawley rats. Forty rats were divided into five groups (eight rats each). Group I received saline (0.5 mL/rat) daily for 10 days and served as the untreated control group. Group II received ACR (30 mg/kg body weight (b.w.)) daily for 10 days. Group III received ACR (30 mg/kg b.w.) daily for 10 days and subsequently minocycline (60 mg/kg b.w.) for five days. Group IV received ACR (30 mg/kg b.w.) daily for 10 days followed by saline for five days and served as the control group for the ACR-minocycline-treated group. Group V received minocycline (60 mg/kg b.w.) for five days. All treatments were administered orally. Rats in group I and V showed normal locomotor behavior and normal histology of the brain and testes. Administration of ACR (Group II and IV) resulted in weight loss and gait abnormalities. Furthermore, neuronal degeneration in the hippocampus and cerebellum and degeneration of the seminiferous tubular epithelium with formation of spermatid giant cells were observed. Ultrastructurally, ACR specifically damaged spermatogonia and spermatocytes. Acrylamide was also seen to cause a significant increase of malondialdehyde levels in the brain and testes. Treatment of ACR-administered rats with minocycline (Group III) significantly alleviated the loss of body weight and improved locomotor function. Minocycline also ameliorated neuronal degeneration and seminiferous tubular damage and decreased malondialdehyde concentrations. In conclusion, minocycline protects against neurotoxic effects of acrylamide and seminiferous tubular damage. Decreasing lipid peroxidation by minocycline might play a role in such protection.

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Section: Discussionsupporting

confidence: 93%

Minocycline protects against acrylamide-induced neurotoxicity and testicular damage in Sprague-Dawley rats

et al. 2020

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“…Both IGFBP‐3 and HSPA1 expression profiles in the present study were altered in the group administered with alpha lipoic acid in combination with ivermectin, where their expressions decreased than the group injected with ivermectin. As well, many studies reported that alpha lipoic acid treatment revealed the ameliorative effect on testicular pathology (Güleş & Eren, ; Lebda, Gad, & Gaafar, and Motawi et al., ). In the current study, histopathological section of testes in the group administered ALA with IVM showed mild testicular degeneration in some seminiferous tubules and nearly normal seminiferous tubules with spermatid and spermatozoa in the tubular lumen (Figure e).…”

Section: Discussionmentioning

confidence: 91%

Effects of ivermectin and its combination with alpha lipoic acid on expression of IGFBP-3 and HSPA1 genes and male rat fertility

El-Maddawy

Naby

2017

Andrologia

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This study was conducted to evaluate the effects of ivermectin (IVM) with therapeutic dose (injected with 0.56 mg/kg b.wt.) either alone or combined with alpha lipoic acid (ALA) (50 mg/kg b.wt daily) on expression of testicular insulin-like growth factor binding protein-3 (IGFBP-3) and heat-shock protein A1 (HSPA1)) genes in the testes, as well as on male rat fertility parameters. Results revealed that expression levels of IGFBP-3 and HSPA1 were significantly increased in testis of the IVM-treated group relative to the control group. Furthermore, injection of ivermectin showed a significant decrease in serum testosterone level, sperm count, motility %, live sperm% and index weight of reproductive organs, and a significant increase in sperm abnormalities. Moreover, IVM induced oxidative stress and pathological alterations in the testes. Meanwhile, the administration of ALA with IVM prevented testicular damage and improved all previous parameters. We concluded that ivermectin has undesirable effects on male fertility and altered expression of IGFBP-3 and HSPA1 genes in the testes, while the administration of alpha lipoic acid can ameliorate the adverse effects of ivermectin.

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“…Another study, conducted via AA administration of 2.5, 10, 50 mg kg −1 bw −1 for 14 days on 7‐week male rats, reported that AA dose‐dependently caused significant decrease in testosterone, progesterone, FSH levels compared to the control group in testis tissues ( Camacho et al, ). In a study, researchers administered 0.05% AA in drinking water and 1% lipoic acid in feed for 21 days to adult male rats and established that AA decreased the total testosterone, progesterone and GSH levels, increased estradiol and MDA levels and caused losses in several seminiferous tubules, giant cell formations and depletion of germinal cells (Lebda, Gad, & Gaafar, ).…”

Section: Discussionmentioning

confidence: 99%

The effects of acrylamide and Vitamin E administration during pregnancy on adult rats testis

et al. 2019

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Thirty rats, with confirmed pregnancies by vaginal smear, were divided into five groups, each including six rats, as the Control, Corn Oil, Vitamin E, Acrylamide, Vitamin E + Acrylamide groups. The births were monitored on the 21st day to select the male rats, and the selected male rats were decapitated at the end of the 8th week. Oxidant–antioxidant parameters, serum hormone levels and histopathological examinations were performed on testis tissues of the rats. It was found that acrylamide (AA) negatively affected the serum hormone levels (Total Testosterone, Progesterone, FSH, LH, Estradiol), oxidant–antioxidant parameters in the tissues (MDA, GSH, NO, SOD, CAT, TAS, TOS) (p < 0.05) and the histological findings (the Johnson's score, seminiferous tubule diameter, histopathological images), and Vitamin E administration resulted with an increase in the total testosterone, progesterone, FSH, LH, GSH, TAS, NO, SOD, CAT levels (p < 0.05) and an improvement in histopathological findings. Currently, it is almost inevitable to be exposed to food‐induced AA toxicity and such toxicity is likely to cause lifelong damage. It was concluded that Vitamin E was able to present a protective effect in the testis tissue against AA toxicity; however, further studies are necessary.

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Effects of Lipoic Acid on Acrylamide Induced Testicular Damage

Cited by 50 publications

References 31 publications

Minocycline protects against acrylamide-induced neurotoxicity and testicular damage in Sprague-Dawley rats

Minocycline protects against acrylamide-induced neurotoxicity and testicular damage in Sprague-Dawley rats

Effects of ivermectin and its combination with alpha lipoic acid on expression of IGFBP-3 and HSPA1 genes and male rat fertility

The effects of acrylamide and Vitamin E administration during pregnancy on adult rats testis

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