Effects of Lifestyle Intervention in Pregnancy and Anthropometrics at Birth on Offspring Metabolic Profile at 2.8 Years: Results From the Lifestyle in Pregnancy and Offspring (LiPO) Study

Tanvig, Mette; Vinter, Christina Anne; Jørgensen, Jan Stener; Wehberg, Sonja; Ovesen, Per; Beck‐Nielsen, Henning; Christesen, Henrik Thybo; Jensen, Dorte Møller

doi:10.1210/jc.2014-2675

Cited by 60 publications

(79 citation statements)

References 30 publications

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“…These results from studies designed as a gestational lifestyle counselling program are in line with our results. On the other hand the results from the Danish study [24] intended to give a postnatal lifestyle counselling differ from our findings. The women in the intervention group in the present study were offered, in addition to the gestational intervention program, an individual visit every six months during the first two years after childbirth in order to discuss behaviour regarding nutrition and physical activity.…”

Section: Discussioncontrasting

confidence: 99%

“…The increase of the ZBMI and ZWL/H, between 2 and 4 years of age was slower among the offspring in the postpartum intervention group than in the control group [14]. In a recent Danish follow-up study of a gestational intervention program for obese women, no ZBMI differences at three years of age were detected between the intervention-and control groups [24]. These results from studies designed as a gestational lifestyle counselling program are in line with our results.…”

Section: Discussionsupporting

confidence: 91%

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Effects of a Gestational Weight Gain Restriction Program for Obese Pregnant Women: Children's Weight Development during the First Five Years of Life

et al. 2016

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Background: Maternal prepregnancy obesity (Body Mass Index, BMI>30 kg/m 2 ) and excessive gestational weight gain (GWG) have shown a strong positive association with a higher BMI and risk of obesity in the offspring. The aim of this study is to estimate the effect of a GWG restriction program for obese pregnant women on the children's BMI at 5 years of age and weight-forlength/height (WL/H) development from two months of age until 5 years of age.Methods: This was a follow-up study of 302 children (137 children in an intervention group and 165 children in a control group) whose mothers participated in a weight gain restriction program during pregnancy.Results: BMI at five years of age did not differ between girls and boys in the intervention-and control group. The degree of maternal GWG, <7 kg or >7 kg, did not affect the offspring's WL/H. Compared with Swedish reference data just over half of the children in both the intervention-and control group had a BMI within the average range, whereas slightly more than one-third of the children had a higher BMI. Conclusion:Despite a comprehensive gestational intervention program for obese women, containing individual weekly visits and opportunity to participate in aqua aerobic classes, there were no differences between BMI or weight development among the offspring at 5 years of age in the intervention-and control group.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 91%

Effects of a Gestational Weight Gain Restriction Program for Obese Pregnant Women: Children's Weight Development during the First Five Years of Life

et al. 2016

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“…32 Observational studies that follow children born of mothers who were participants in lifestyle interventions targeting gestational weight gain or gestational diabetes have not found a ''spillover'' effect on childhood obesity or metabolic profile. [32][33][34] Grounding interventions in life course theoretical models and developing solution-focused intervention strategies that cover both prenatal and early postnatal behavioral changes may be needed to advance the evidence base in this area. 1 In short, comprehensive and effective childhood obesity prevention will require targeting factors at different developmental windows in order to meaningful affect the prevalence of obesity in the population.…”

Section: Discussionmentioning

confidence: 99%

Association between Prepregnancy Body Mass Index and Gestational Weight Gain with Size, Tempo, and Velocity of Infant Growth: Analysis of the Newborn Epigenetic Study Cohort

et al. 2016

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Background: The first 1000 days of life is a critical period of infant growth that has been linked to future adult health. Understanding prenatal factors that contribute to variation in growth during this period could inform successful prevention strategies.Methods: Prenatal and maternal characteristics, including prepregnancy obesity and gestational weight gain were evaluated in relation to weight growth trajectories during the first 24 months of life using the SuperImposition by Translation and Rotation (SITAR) method, which provides estimates of infant size, timing to peak velocity, and growth velocity. The study sample included 704 mother-infant dyads from a multiethnic prebirth cohort from the Southeastern United States. The total number of weight measures was 8670 (median number per child = 14).Results: Several prenatal and maternal characteristics were linked with infant growth parameters. The primary findings show that compared to women with a prepregnancy BMI between 18 and 24.9, women with a prepregnancy BMI ‡40 had infants that were 8% larger during the first 24 months, a delayed tempo of around 9 days, and a slower velocity. Mothers who had greater than adequate gestational weight gain had infants that were 5% larger even after controlling for prepregnancy BMI and several other covariates.Conclusions: The findings contribute new data on the associations between gestational weight gain and aspects of early growth using the SITAR method, and support a growing consensus in the literature that both prepregnancy BMI and gestational weight gain relate independently to risk for greater postnatal weight growth.

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“…Similar to our study, the few studies that have reported on infant growth after prenatal interventions have found no changes in infant growth. This includes two previous European studies with null results 27,28 and one study in the United States evaluating a walking intervention during pregnancy that followed babies to 6 months postpartum. 29 Biological explanations for these null findings have been proposed.…”

Section: Discussionmentioning

confidence: 99%

Infant Growth following Maternal Participation in a Gestational Weight Management Intervention

et al. 2016

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Background: Obesity is widespread and treatment strategies have demonstrated limited success. Changes to obstetrical practice in response to obesity may support obesity prevention by influencing offspring growth trajectories.Methods: This retrospective cohort study examined growth among infants born to obese mothers who participated in Nutrition in Pregnancy (NIP), a prenatal nutrition intervention at one urban hospital. NIP participants had Medicaid insurance and BMIs of 30 kg/m

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Effects of Lifestyle Intervention in Pregnancy and Anthropometrics at Birth on Offspring Metabolic Profile at 2.8 Years: Results From the Lifestyle in Pregnancy and Offspring (LiPO) Study

Cited by 60 publications

References 30 publications

Effects of a Gestational Weight Gain Restriction Program for Obese Pregnant Women: Children's Weight Development during the First Five Years of Life

Effects of a Gestational Weight Gain Restriction Program for Obese Pregnant Women: Children's Weight Development during the First Five Years of Life

Association between Prepregnancy Body Mass Index and Gestational Weight Gain with Size, Tempo, and Velocity of Infant Growth: Analysis of the Newborn Epigenetic Study Cohort

Infant Growth following Maternal Participation in a Gestational Weight Management Intervention

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