Effects of lifestyle and single nucleotide polymorphisms on breast cancer risk: a case–control study in Japanese women

Mizoo, Taeko; Taira, Naruto; Nishiyama, Koichiro; Nogami, Tomohiro; Inomata, Takayuki; Motoki, Takayuki; Shien, Tadahiko; Matsuoka, Junji; Doihara, Hiroyoshi; Ishihara, Setsuko; Kawai, Hiroshi; Kawasaki, K.; Ishibe, Y; Ogasawara, Yuki; Komoike, Yoshifumi; Miyoshi, Shinichiro

doi:10.1186/1471-2407-13-565

Cited by 45 publications

(53 citation statements)

References 31 publications

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“…The frequency of allele A in this study is 42.8% in the total sample set and 37.69% in control group, supported the data of previous studies in the Asian population, which was about 34.8 -39.3% Han et al, 2011). Specifically, in this study, 37.69% allele A in the control group was in the same range as the reported 34% in Caucasian descendants, 37.8% in Chinese (Hap Map-HCB) and 30.0% in Japanese (Hap Map -JTP) (Mizoo et al, 2013). Distribution of this allele in Vietnamese which is the same as its distribution in other populations in Asia can be understood as they are in the same geography distribution and may share the same genetic distribution.…”

Section: Discussionsupporting

confidence: 91%

“…This polymorphism was significantly associated with the risk of breast cancer in different Asian populations, including Chinese with strong association [ORs (95% CI) = 1.35 (1.17 -1.57), p = 4.1×10-5 for allelic analysis and [P for trend = 1.54×10−30] (Lin et al, 2014). In Japanese women, the allele A has been strongly associated with breast cancer with [ORs (95% CI) = 1.37 (1.11 -1.70), p = 0.05] (Mizoo et al, 2013) or [ORs (95% CI) = 1.31 (1.13 -1.52) and 1.37 (1.06 -1.76) for the AG and AA genotypes, p for trend = 2.51×10−4] (Cai et al, 2011). SNP rs2046210 had a population attributable risk of 18.9% plus an estimated 2.1% excess familial risk of breast cancer (Zheng et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

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Association of a single nucleotide polymorphism at 6q25.1, rs2046210 with breast cancer risk among Vietnamese population

et al. 2016

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Introduction: This study aims to confirm the association between SNP rs2046210 and breast cancer in the Vietnamese population. Methods: A case/control study has been performed with the sample size of 300 cases and 325 controls. High Resolution Melting method is optimised for SNP genotyping. Statistic logistic regression analysis was used along with dominant and recessive analysis to analyse the association between alleles and genotypes of the selected SNP and breast cancer risk. Results: With the selection population and the optimal HRM method, genotyping resulted in precise data for association analysis as the HWE test showed the distribution of genotypes in the population is in equilibrium (p > 0.05). The logistic regression association analysis showed SNP rs2046210 strongly associated with breast cancer risk in both allelic (p = 0.0015) and genotypic (p = 0.0064) analysis. The risk allele A, like other previous studies, strongly associated with increasing the risk of breast cancer up to 1.425 folds (OR [95%CI] = 1.425 [1.143-1.777], p = 0.0015). However, it has shown the recessive effect in the additive analysis. Genotype AA showed stronger effect on the risk of breast cancer while the heterozygous AG genotypes showed weaker effect. Due to the small sample size, statistical power of this study is not high as expected (58.67%). But this case/control study confirms the association between SNP rs2046210 and the risk of breast cancer in the Vietnamese population. Conclusion: SNP rs2046210 is associated with breast cancer risk in the Vietnamese population. The risk allele A plays a role in increasing the risk of breast cancer in Vietnamese women.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Association of a single nucleotide polymorphism at 6q25.1, rs2046210 with breast cancer risk among Vietnamese population

et al. 2016

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“…When stratified by ethnicity, this significance was lost in those of African descent, but it was maintained in European and Asian populations. Mizoo et al (2013) performed a case-control study that associated rs2046210 with higher BC risk in Japanese women. Our results also suggest that rs2046210 T allele carriers (TC and TT genotypes) have a significantly elevated BC risk compared with those with CC genotypes.…”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphisms and haplotype of hormone-related genes are associated with the risk of breast cancer in Chinese women

Pan¹,

Song³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Sex hormones play important roles in breast cancer (BC) development. This study investigated associations between BC risk and hormone-related gene variants in Chinese women. In a cohort of 336 patients with histopathologically confirmed BC and 390 age-matched controls, we genotyped seven single nucleotide polymorphisms (SNPs) in five hormone-related genes: estrogen receptor-α (ESR1), aromatase (CYP19), catechol-O-methyl transferase (COMT), sex hormonebinding globulin (SHBG), and glutathione S-transferase (GSTP1). Among these seven SNPs, the SNPs in GSTP1 rs1695 [A/G; odds ratio (OR): 1.68; 95% confidence interval (CI): 1.23-2.30] and ESR1 rs2046210 (C/T; OR: 1.39; 95%CI = 1.02-1.91) were associated with an increased risk among heterozygote carriers. Homozygotes of minor alleles of CYP19 rs10046 (CC) were associated with a reduced risk of BC with OR: 0.61 (95%CI = 0.39-0.95). In addition, a stratified analysis by menopausal status indicated that the association of the CYP19 polymorphisms (rs10046 and rs700519) with BC risk was mainly evident in premenopausal women, and the association of CYP19 rs700519 with BC risk was significant in women less than 50 years old. Haplotype analysis identified 15 common haplotypes (>1%). The haplotype TGGGGTC was significantly associated with BC risk compared with the reference haplotype CGAGGTC (OR > 1000, P < 0.0001). Our data demonstrate that these ESR1, GSTP1, and CYP19 polymorphisms are associated with risk of BC, and the risk haplotype TGGGGTC could help to identify populations with high susceptibility to BC in Chinese women.

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“…Moreover, another GWAS of 1600 Icelandic BC patients and 11,563 controls, followed by a replication study of 4554 affected individuals and 17,577 control subjects, showed the rs3803662 C>T TNRC9 variant to be associated with increased ER-positive BC risk (Stacey et al, 2007). However, in a Japanese study, the rs3803662 T allele exhibited no connection with risk of BC (Mizoo et al, 2013). As conflicting results have been obtained, the clinical importance of this polymorphic gene is uncertain.…”

Section: Discussionmentioning

confidence: 99%

“…In total, 18 studies involving 44,820 cases and 58,316 controls met the inclusion criteria and were used in pooled analyses (Antoniou et al, 2008;Garcia-Closas et al, 2008;Li et al, 2009;Mcinerney et al, 2009;Gorodnova et al, 2010;Latif et al, 2010;Liang et al, 2010;Tamimi et al, 2010;Campa et al, 2011;Han et al, 2011;Slattery et al, 2011;Harlid et al, 2012;Shan et al, 2012;Mizoo et al, 2013;Ottini et al, 2013;Chen et al, 2014;Elematore et al, 2014). The primary features of these investigations are shown in Table 1.…”

Section: Study Characteristicsmentioning

confidence: 99%

Increased risk of breast cancer in individuals carrying the TNRC9 rs3803662 C>T polymorphism: a meta-analysis of case-control studies

Wang

Cao

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Currently, the relationship between the trinucleotide repeat containing 9 (TNRC9) rs3803662 C>T polymorphism and risk of breast cancer (BC) is uncertain. Here, we attempted to obtain a more accurate assessment of this association by conducting a meta-analysis of all eligible case-control investigations, comprising 44,820 cases and 58,316 controls. A comprehensive search was performed to identify all suitable studies involving the TNRC9 rs3803662 polymorphism and BC risk. Pooled odds ratios (ORs) and 95% confidence intervals (95%CIs) were estimated using fixed-or random-effect models. Heterogeneity, publication bias, and sensitivity analyses were also carried out. We found that the variant T allele of rs3803662 C>T greatly increases BC risk (CT vs CC: OR = 1.14, 95%CI = 1.07-1.22, P < 0.001; TT vs CC: OR = 1.38, 95%CI = 1.25-1.53, P < 0.001; CT/TT vs CC: OR = 1.19, 95%CI = 1.11-1.28, P < 0.001; TT vs CT/CC: OR = 1.28, 95%CI = 1.19-1.38, P < 0.001). Stratified analysis based on ethnicity also revealed a markedly increased risk in Asian and Caucasian populations. Moreover, studies with hospital-based control groups showed elevated risk under the four genetic models employed, as did those using population-based controls, except under heterozygote comparison. The TNRC9 rs3803662 C>T polymorphism is greatly related to increased risk of BC, in both Asian and Caucasian populations.

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Effects of lifestyle and single nucleotide polymorphisms on breast cancer risk: a case–control study in Japanese women

Cited by 45 publications

References 31 publications

Association of a single nucleotide polymorphism at 6q25.1, rs2046210 with breast cancer risk among Vietnamese population

Association of a single nucleotide polymorphism at 6q25.1, rs2046210 with breast cancer risk among Vietnamese population

Genetic polymorphisms and haplotype of hormone-related genes are associated with the risk of breast cancer in Chinese women

Increased risk of breast cancer in individuals carrying the TNRC9 rs3803662 C>T polymorphism: a meta-analysis of case-control studies

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