Effects of Lidocaine on the Anesthetic Requirements for Nitrous Oxide and Halothane

Himes, Richard S.; DiFazio, Cosmo A.; Burney, Robert G.

doi:10.1097/00132586-197812000-00034

Cited by 36 publications

(61 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lidocaine is a commonly used local anesthetic. Intravenous lidocaine infusion has been used in clinical practice for many years to reduce the required concentrations of general anesthetics during surgery [17]. The novel lidocaine effect identified in this study can be readily applied to clinical practice if this effect is confirmed in humans.…”

Section: Discussionmentioning

confidence: 91%

“…Neuroinflammation, Aβ accumulation, neurodegeneration and hyperphosphorylated tau accumulation are key pathological features of AD brains [13,16]. Lidocaine, a local anesthetic, decreases required concentrations of general anesthetics to maintain anesthesia [17] and has neuroprotective and anti-inflammatory effects when given systemically [18-20]. Thus, we hypothesize that isoflurane induces cognitive impairment and AD-like neuropathology and that lidocaine attenuates these changes in aged animals.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lidocaine attenuates cognitive impairment after isoflurane anesthesia in old rats

Lin

Cao

Wang

et al. 2012

Behavioural Brain Research

View full text Add to dashboard Cite

Post-operative cognitive dysfunction (POCD) is a clinical phenomenon that has drawn significant attention from the public and scientific community. Age is a risk factor for POCD. However, the contribution of general anesthesia/anesthetics to POCD and the underlying neuropathology are not clear. Here, we showed that 18-month-old male Fisher 344 rats exposed to 1.2% isoflurane, a general anesthetic, for 2 h had significant learning and memory impairments assessed at 2 to 4 weeks after isoflurane exposure. These isoflurane effects were attenuated by intravenous lidocaine (1.5 mg/kg as a bolus and then 2 mg/kg/h during isoflurane exposure), a local anesthetic that has neuroprotective effect. Exposure to isoflurane or isoflurane plus lidocaine did not change the neuronal and synaptic density as well as the expression of NeuN (a neuronal protein), drebrin (a dendritic spine protein), synaptophysin (a synaptic protein), activated caspase 3 and caspase-activated DNase in the hippocampus at 29 days after isoflurane exposure when cognitive impairment was present. Isoflurane and lidocaine did not affect the amount of β-amyloid peptide, total tau and phospho-tau in the cerebral cortex as well as interleukin-1β and tumor necrosis factor-α in the hippocampus at 29 days after isoflurane exposure. Thus, isoflurane induces learning and memory impairment in old rats. Lidocaine attenuates these isoflurane effects. Isoflurane may not cause long-lasting neuropathological changes.

show abstract

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Lidocaine attenuates cognitive impairment after isoflurane anesthesia in old rats

Lin

Cao

Wang

et al. 2012

Behavioural Brain Research

View full text Add to dashboard Cite

show abstract

“…In the study reported here, we did not observe any difference between the groups with respect to expired isoflurane concentrations during anesthesia. Lidocaine has been reported to reduce the minimum alveolar concentration of a variety of inhalant anesthetics, including halothane, nitrous oxide, and isoflurane (Himes et al. 1977; Sorrell 1980; Doherty & Frazier 1998).…”

Section: Discussionmentioning

confidence: 99%

“…1977; Sorrell 1980; Doherty & Frazier 1998). In one study, lidocaine administered to achieve plasma concentrations of 3–6 µg mL −1 reduced halothane requirements up to 28% (Himes et al. 1977).…”

Section: Discussionmentioning

confidence: 99%

Systemic lidocaine infusion as an analgesic for intraocular surgery in dogs: a pilot study

Smith

Bentley

Shih

et al. 2004

Veterinary Anaesthesia and Analgesia

View full text Add to dashboard Cite

“…A possible interaction between local and general anesthetics has attracted the interest of investigators; specifically, lidocaine has been found to produce a minimum alveolar concentration (MAC)- sparing effect of 10–28% [7], and also to reduce propofol requirements during total intravenous anesthesia [8]. The combination of drugs with such interaction could be extremely useful if applied in situations with high risk of awareness, such as RSII.…”

Section: Introductionmentioning

confidence: 99%

Intravenous lidocaine does not affect the anesthetic depth during rapid sequence induction and intubation as assessed by Bispectral Index monitoring: a randomized double blind study

Staikou¹,

Paraskeva²,

Karmaniolou³

et al. 2013

aoms

View full text Add to dashboard Cite

IntroductionWe investigated the impact of intravenous lidocaine on anesthetic depth, as assessed by Bispectral Index score (BIS), and hemodynamic responses to rapid sequence induction/intubation.Material and methodsEighty-four surgical patients with risk factors for regurgitation/aspiration were randomized to receive either lidocaine 1.5 mg/kg or normal saline in a double-blind fashion. Propofol 2 mg/kg, lidocaine or normal saline, followed by rocuronium 1 mg/kg were administered intravenously and trachea was intubated under cricoid pressure application. The BIS scores were recorded before induction of anesthesia, immediately after, at 30 s and 1 min after rocuronium injection and every 30 s after intubation, for 10 min. Systolic/diastolic blood pressure and heart rate were measured before induction, immediately after and at 1 min following rocuronium administration, and every minute for 10 min after intubation.ResultsData from 78 patients were analyzed. Demograpic characteristics did not differ between the study groups. A total of 24 BIS scores were recorded for each patient. No difference was found in BIS values between lidocaine and control groups at any time point (F = 2.936, p = 0.91). Also no difference was detected in heart rate, systolic and diastolic blood pressure at any time point of the study period between the two groups (F = 0.063, p = 0.80, F = 0.007, p = 0.93, F = 0.435, p = 0.51 respectively). No episodes of significant bradycardia occurred and none of the patients reported awareness/recall of the procedure.ConclusionsLidocaine 1.5 mg/kg given intravenously during rapid sequence induction does not affect BIS values, or blunt the hemodymanic response to laryngoscopy and intubation.

show abstract

Effects of Lidocaine on the Anesthetic Requirements for Nitrous Oxide and Halothane

Cited by 36 publications

References 0 publications

Lidocaine attenuates cognitive impairment after isoflurane anesthesia in old rats

Lidocaine attenuates cognitive impairment after isoflurane anesthesia in old rats

Systemic lidocaine infusion as an analgesic for intraocular surgery in dogs: a pilot study

Intravenous lidocaine does not affect the anesthetic depth during rapid sequence induction and intubation as assessed by Bispectral Index monitoring: a randomized double blind study

Contact Info

Product

Resources

About