Effects of Levosimendan on Markers of Left Ventricular Diastolic Function and Neurohormonal Activation in Patients With Advanced Heart Failure

Parissis, John; Panou, Fotios; Farmakis, Dimitrios; Adamopoulos, Stamatis; Filippatos, Gerasimos; Paraskevaidis, Ioannis; Venetsanou, Koula; Lekakis, John; Kremastinos, Dimitrios Th.

doi:10.1016/j.amjcard.2005.03.092

Cited by 98 publications

(103 citation statements)

References 14 publications

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“…There are no previous data about the levosimendan effect in patients with advanced but stable chronic HF; however, two previous studies have shown improvement in haemodynamic function measured by invasive haemodynamic monitoring in patients with decompensated HF 12, 28. Moreover, we confirmed findings from previous studies documenting that levosimendan also reduces NT‐pro‐BNP, MAP, and eTPR 29, 30, 31. However, given that levosimendan is frequently used in stable HF despite a lack of convincing evidence or indications, we also examined whether baseline clinical and haemodynamic factors affected the response to levosimendan and observed no significant association between baseline clinical or haemodynamic parameters and levosimendan effect on CO.…”

Section: Discussionsupporting

confidence: 90%

Haemodynamic effects of levosimendan in advanced but stable chronic heart failure

et al. 2018

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AimsLevosimendan improves haemodynamics in acute decompensated heart failure (HF). However, it is increasingly used for repetitive or intermittent infusions in advanced but stable chronic HF, without clear indication, selection criteria, or effect. We tested the hypotheses that (1) levosimendan improves haemodynamics in stable chronic HF and (2) that the response is dependent on baseline clinical and haemodynamic factors.Methods and resultsTwenty‐three patients [median age 56 (49–64) years, four (17%) women] with stable New York Heart Association (NYHA) III and IV HF received a single 24 h levosimendan infusion. Non‐invasive haemodynamics (inert gas re‐breathing technique), estimated glomerular filtration rate, and N‐terminal pro‐brain natriuretic peptide were assessed before and after infusion. Levosimendan had the following effects (median change): a significant increase in cardiac output (+9.8 ± 21.6%; P = 0.026) and decrease in N‐terminal pro‐brain natriuretic peptide (−28.1 ± 16.3%, P < 0.001), estimated total peripheral resistance (−16.9 ± 18.3%, P = 0.005), and mean arterial pressure (−5.9 ± 8.2%, P = 0.007), but no change in estimated glomerular filtration rate (+0.89 ± 14.0%, P = 0.955). There were no significant associations between baseline clinical and/or haemodynamic factors and the levosimendan effect on cardiac output.ConclusionsLevosimendan was associated with improved haemodynamics in patients with stable chronic HF, but we could not identify any predictors of the magnitude of haemodynamic response.

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Section: Discussionsupporting

confidence: 90%

Haemodynamic effects of levosimendan in advanced but stable chronic heart failure

et al. 2018

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“…Only one study reported rates of rehospitalization individually and three studies reported length of stay. As the study conducted by Parissi et al 11 did not provide separate data for mortality and length of stay, and as there was no other study in which this data were presented on an aggregated form, the Parissi study was not included in our meta-analysis calculations.…”

Section: Resultsmentioning

confidence: 99%

Levosimendan na insuficiência cardíaca descompensada: revisão sistemática e metanálise

Ribeiro¹,

Rohde²,

Polanczyk³

2010

Arq. Bras. Cardiol.

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“…Raised cAMP concentrations causes intracellular calcium to increase, which exacerbates diastolic dysfunction [1]. Parissis et al [19] showed that levosimendan infusion improved echocardiographic markers of abnormal LV diastolic function. Consistent with this study, in our study a levosimendan infusion lead to a significant increase in mitral A wave and deceleration time and a significant decrease in E/A and E/E' ratios.…”

Section: Discussionmentioning

confidence: 99%

Assessment of sustained effects of levosimendan and dobutamine on left ventricular systolic functions by using novel tissue Doppler derived indices in patients with advanced heart failure

Oner

Ertürk²,

Birant³

et al. 2015

Cardiol J

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Effects of Levosimendan on Markers of Left Ventricular Diastolic Function and Neurohormonal Activation in Patients With Advanced Heart Failure

Cited by 98 publications

References 14 publications

Haemodynamic effects of levosimendan in advanced but stable chronic heart failure

Haemodynamic effects of levosimendan in advanced but stable chronic heart failure

Levosimendan na insuficiência cardíaca descompensada: revisão sistemática e metanálise

Assessment of sustained effects of levosimendan and dobutamine on left ventricular systolic functions by using novel tissue Doppler derived indices in patients with advanced heart failure

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