Effects of leukocyte- and platelet-rich fibrin alone and combined with hyaluronic acid on early soft tissue healing after surgical extraction of impacted mandibular third molars: A prospective clinical study

Afat, İbrahim Murat; Akdoğan, Emine Tuna; Gönül, Onur

doi:10.1016/j.jcms.2018.11.023

Cited by 41 publications

(30 citation statements)

References 30 publications

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“…Afat et al (19) reported that L-PRF combined with HA may be effective to prevent post-extraction infection and alveolar osteitis in mandibular third molars. On the other hand, in a randomized clinical trial by Bayoumi et al (20), it was reported that HA administration after tooth extraction does not affect the occurrence of alveolar osteitis or alleviate postoperative pain effectively when compared to a control group.…”

Section: Discussionmentioning

confidence: 99%

The comparison of the efficacy of Alveogyl, 0.8% Hyaluronic acid, and 0.2% Chlorhexidine Digluconate in alveolar osteitis

2021

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Aim: The aim of this study was to compare the efficacy of Alveogyl, 0.8% hyaluronic acid (HA), and 0.2% chlorhexidine digluconate (CHX) gel in reducing pain and improving clinical signs and symptoms of alveolar osteitis. Methodology: The clinical data of patients treated for alveolar osteitis between 01/01/2015 and 01/01/2019 were retrieved for this study. All patients were initially treated by curettage and physiological saline irrigation. Patients were then divided into 4 groups. Group 1 was considered the control group; no other biomaterials were administered after curettage and physiological saline irrigation. All other groups were administered an additional treatment in the socket after curettage and physiological saline irrigation (Group 1 – Alveogyl; Group 2 - 0.8% HA; Group 3 - 0.2% CHX). Patents were evaluated before surgery as well as days 3 and 7 after surgery. The postoperative evaluations included: Visual analog scale(VAS) pain scores, the presence of clinical signs and symptoms of exposed alveolar bone, disorganized blood clot, inflammation around the socket, and bad odor and taste. Results: Sixty-seven patients were included in the study. There was no statistically significant difference between groups in all control evaluations (p>0.05). There was significantly reduced inflammation around the extraction socket on postoperative day 7 in the CHX group compared to that in the control group (p<0.05). No other significant changes in clinical signs and symptoms were observed among groups. Conclusion: There was no significant difference between curettage with physiological saline irrigation alone and the addition of Alveogyl, 0.8% HA, or 0.2% CHX in the reduction of pain in alveolar osteitis. Nonetheless, CHX may reduce inflammation around the extraction sockets. How to cite this article: Dereci Ö, Görkem T, Koşar YÇ. The comparison of the efficacy of Alveogyl, 0.8% Hyaluronic acid, and 0.2% Chlorhexidine Digluconate in alveolar osteitis. Int Dent Res 2021;11(1):6-11. https://doi.org/10.5577/intdentres.2021.vol11.no1.2 Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

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Section: Discussionmentioning

confidence: 99%

The comparison of the efficacy of Alveogyl, 0.8% Hyaluronic acid, and 0.2% Chlorhexidine Digluconate in alveolar osteitis

2021

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“…Recent studies [27,30] have also shown that alveoli filled with PRF membrane have accelerated soft tissue healing (epithelialization), especially in the first week, when compared to spontaneous healing.…”

Section: Discussionmentioning

confidence: 99%

Does Platelet-Rich Fibrin Decrease Dimensional Changes and Improve Postoperative Comfort in Post-Extraction Sockets? An Overview of Systematic Reviews

et al. 2020

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This overview aimed to evaluate the methods, quality, and outcomes of systematic reviews (SRs) conducted to investigate the effects of platelet-rich fibrin (PRF) in dental sockets on promoting bone regeneration and soft tissue healing and diminishing the incidence of pain, swelling, trismus, and alveolar osteitis after tooth extraction. An electronic search without date or language restriction was done in PubMed/MEDLINE, Cochrane, and Web of Science until March 2020. Eligibility criteria included SRs that assessed the effect of PRF for human alveolar socket preservation. The quality assessment of the included studies was performed using AMSTAR 2 guidelines. The protocol of this overview was recorded in PROSPERO under the number CRD42018089617. The search and selection process yielded 13 studies published between 2011 and 2018. The analysis of the studies showed inconclusive data for the effect of the PRF and the dimensional changes. There is no definitive evidence for the impact of using PRF alone on bone regeneration in post-extraction sockets. The use of PRF improves soft tissue healing and reduces pain, bleeding, and osteitis in post-extraction sockets.

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“…The above study confirmed the advisability of using cross-linked HA as a carrier for growth factors in tissue engineering and, at the same time, as a formulation ingredient to support osteogenesis [ 96 , 97 ]. In the study by Afat et al [ 45 ], a porous HA-based matrix with incorporated platelet-rich fibrin (Leukocyte-Platelet Rich Fibrin, L-PRF), obtained from centrifuged patient blood, was introduced into the dental alveoli after extraction of third molars. After matrix application, a significant reduction in postoperative complications alongside a shorter wound healing time was observed compared to a control group of patients whose post-extraction dental alveoli were left to heal spontaneously.…”

Section: Carriers and Biodegradable Polymeric Materials In Dentistrymentioning

confidence: 99%

Polymer-Based Carriers in Dental Local Healing—Review and Future Challenges

et al. 2021

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Polymers in drug formulation technology and the engineering of biomaterials for the treatment of oral diseases constitute a group of excipients that often possess additional properties in addition to their primary function, i.e., biological activity, sensitivity to stimuli, mucoadhesive properties, improved penetration of the active pharmaceutical ingredient (API) across biological barriers, and effects on wound healing or gingival and bone tissue regeneration. Through the use of multifunctional polymers, it has become possible to design carriers and materials tailored to the specific conditions and site of application, to deliver the active substance directly to the affected tissue, including intra-periodontal pocket delivery, and to release the active substance in a timed manner, allowing for the improvement of the form of application and further development of therapeutic strategies. The scope of this review is polymeric drug carriers and materials developed from selected multifunctional groups of natural, semi-synthetic, and synthetic polymers for topical therapeutic applications. Moreover, the characteristics of the topical application and the needs for the properties of carriers for topical administration of an active substance in the treatment of oral diseases are presented to more understand the difficulties associated with the design of optimal active substance carriers and materials for the treatment of lesions located in the oral cavity.

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Effects of leukocyte- and platelet-rich fibrin alone and combined with hyaluronic acid on early soft tissue healing after surgical extraction of impacted mandibular third molars: A prospective clinical study

Cited by 41 publications

References 30 publications

The comparison of the efficacy of Alveogyl, 0.8% Hyaluronic acid, and 0.2% Chlorhexidine Digluconate in alveolar osteitis

The comparison of the efficacy of Alveogyl, 0.8% Hyaluronic acid, and 0.2% Chlorhexidine Digluconate in alveolar osteitis

Does Platelet-Rich Fibrin Decrease Dimensional Changes and Improve Postoperative Comfort in Post-Extraction Sockets? An Overview of Systematic Reviews

Polymer-Based Carriers in Dental Local Healing—Review and Future Challenges

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