Effects of lesions of amygdaloid nuclei and substantia nigra on aversive responses induced by electrical stimulation of the inferior colliculus

Maisonnette, Sílvia; Kawasaki, Mateus C.; Coimbra, Norberto Cysne; Brandão, Marcus Lira

doi:10.1016/0361-9230(95)02136-1

Cited by 94 publications

(39 citation statements)

References 34 publications

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“…Supporting this statement, an independent group of animals submitted to the same procedure, except for the pairing of tone with footshock, showed reliable learning rates comparable to those from typical avoidance-escape procedures that utilize an auditory stimulus paired with electric shock as the unconditioned stimulus (21,22). One possible explanation for these surprising results is that repeated electrical stimulation of tomical connections between the inferior colliculus and these structures (17,18). The present results show that rats quickly learn to make a shuttling response in order to avoid or escape from electrical stimulation of the inferior colliculus.…”

Section: Discussionmentioning

confidence: 58%

“…In support of this possibility it has been shown that repeated stimulation of the inferior colliculus resulted in modified sensitivity of its neural network and in a chronic susceptibility to spontaneous seizures (1). This shortcoming could lead to disturbances in the transmission of the to-be conditioned stimulus to a higher brain level, such as the amygdala, with which the inferior colliculus has an anatomical and functional relationship (18). Evidence showing that the steps of sensory processing are modulated during learning procedures (24,25) supports this possibility.…”

Section: Discussionmentioning

confidence: 95%

“…As a matter of fact, there are important connections between the inferior colliculus and the dorsal periaqueductal gray matter (17). Furthermore, recent findings from this laboratory have shown that lesion of the central nucleus of the amygdala attenuates, while lesion of the basolateral complex enhances the aversive consequences of the electrical stimulation of the inferior colliculus (18).…”

Section: Discussionmentioning

confidence: 97%

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Signaled two-way avoidance learning using electrical stimulation of the inferior colliculus as negative reinforcement: effects of visual and auditory cues as warning stimuli

Troncoso

Cirilo-Júnior

Sandner

et al. 1998

Braz J Med Biol Res

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The inferior colliculus is a primary relay for the processing of auditory information in the brainstem. The inferior colliculus is also part of the so-called brain aversion system as animals learn to switch off the electrical stimulation of this structure. The purpose of the present study was to determine whether associative learning occurs between aversion induced by electrical stimulation of the inferior colliculus and visual and auditory warning stimuli. Rats implanted with electrodes into the central nucleus of the inferior colliculus were placed inside an open-field and thresholds for the escape response to electrical stimulation of the inferior colliculus were determined. The rats were then placed inside a shuttle-box and submitted to a two-way avoidance paradigm. Electrical stimulation of the inferior colliculus at the escape threshold (98.12 ± 6.15 (A, peak-to-peak) was used as negative reinforcement and light or tone as the warning stimulus. Each session consisted of 50 trials and was divided into two segments of 25 trials in order to determine the learning rate of the animals during the sessions. The rats learned to avoid the inferior colliculus stimulation when light was used as the warning stimulus (13.25 ± 0.60 s and 8.63 ± 0.93 s for latencies and 12.5 ± 2.04 and 19.62 ± 1.65 for frequencies in the first and second halves of the sessions, respectively, P<0.01 in both cases). No significant changes in latencies (14.75 ± 1.63 and 12.75 ± 1.44 s) or frequencies of responses (8.75 ± 1.20 and 11.25 ± 1.13) were seen when tone was used as the warning stimulus (P>0.05 in both cases). Taken together, the present results suggest that rats learn to avoid the inferior colliculus stimulation when light is used as the warning stimulus. However, this learning process does not occur when the neutral stimulus used is an acoustic one. Electrical stimulation of the inferior colliculus may disturb the signal transmission of the stimulus to be conditioned from the inferior colliculus to higher brain structures such as amygdala.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 97%

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Signaled two-way avoidance learning using electrical stimulation of the inferior colliculus as negative reinforcement: effects of visual and auditory cues as warning stimuli

Troncoso

Cirilo-Júnior

Sandner

et al. 1998

Braz J Med Biol Res

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“…An indirect pathway connecting these structures is given by projections from the central nucleus of the IC-medial geniculate nucleusamygdala-dorsomedial thalamus-prefrontal cortex (Fuster, 1989;Brodal, 1992;Cardoso et al, 1994). It has been shown that this alternate circuit is concerned with the processing of auditory information of aversive nature, which triggers fear-like behaviors (LeDoux et al, 1990;Maisonnette et al, 1996). Support to this assumption comes from a recent paper demonstrating that microinjections of nefazodone, a serotonin antagonist, into the basolateral nucleus of amygdala reduce the aversive reactions induced by NMDA microinjections into the IC (Maisonnette et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Apomorphine Enhances Conditioned Responses Induced by Aversive Stimulation of the Inferior Colliculus

Troncoso¹,

Osaki²,

Mason³

et al. 2003

Neuropsychopharmacol

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Consistent evidence has shown that learning may be produced in paradigms using electrical stimulation of the inferior colliculus (IC) as unconditioned stimulus (UCS). Recent reports have also demonstrated that aversive stimulation of the IC, at the escape threshold, enhances dopamine (DA) release in the prefrontal cortex. The purpose of the present study was to determine whether dopaminergic mechanisms are involved in the Pavlovian conditioning and latent inhibition using IC stimulation as UCS and light as conditioned stimulus (CS). Rats were placed inside a shuttle box and subjected to a two-way avoidance paradigm. IC aversive electrical stimulation was used as UCS and shuttle box illumination as CS. The rats quickly learned to avoid or interrupt the IC stimulation. Apomorphine injections produced a dose-dependent increase in the number of avoidance responses. On the other hand, chlorpromazine administration promoted a dose-dependent reduction of the avoidance responses. Previous injections of chlorpromazine inhibited the effects of apomorphine. Also, previous exposure to unreinforced light weakened the strength of the conditioning. Apomorphine blocked this latent inhibition effect, which was antagonized by previous injections of chlorpromazine. These findings bring evidence for the involvement of DA in the setting up of adaptive responses to aversive states generated at the IC level, which may underlie stressful situations present in anxiety.

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“…For example, the connections of the inferior colliculus to the amygdala act as an important filter for sensorial information of an aversive nature (15). Based on these data, we suggest that the fish submitted to telencephalic ablation were able to learn the inhibitory avoidance task due to the local circuits of the midbrain, and that CPA facilitated retention of an aversive experience, as a type of defensive behavior (16), for at least 24 h.…”

mentioning

confidence: 77%

Chlorpheniramine facilitates inhibitory avoidance in teleosts submitted to telencephalic ablation

Faganello

Mattioli

2008

Braz J Med Biol Res

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The present study investigated the involvement of H(1) histaminegic receptor on the acquisition of inhibitory avoidance in Carassius auratus submitted to telencephalic ablation. The fish were submitted to telencephalic ablation 5 days before the experiment. The inhibitory avoidance procedure included 1 day for habituation, 3 days for training composed of 3 trials each (1st day: T1, T2, T3; 2nd day: 2T1, 2T2, 2T3; 3rd day: 3T1, 3T2, 3T3) and 1 day for test. On training days, the fish were placed in a white compartment, after 30 s the door was opened. When the fish crossed to a black compartment, a weight was dropped (aversive stimuli). Immediately after the third trial, on training days, the fish received, intraperitoneally, one of the pharmacological treatments (saline (N = 20), 8 (N = 12) or 16 (N = 13) µg/g chlorpheniramine, CPA). On the test day, the time to cross to the black compartment was determined. The latency of the saline group increased significantly only on the 3rd trial of the 2nd training day (mean ± SEM, T1 (50.40 ± 11.69), 2T3 (226.05 ± 25.01); ANOVA: P = 0.0249, Dunn test: P < 0.05). The group that received 8 µg/g CPA showed increased latencies from the 2nd training day until the test day (T1 (53.08 ± 17.17), 2T2 (197.75 ± 35.02), test (220.08 ± 30.98); ANOVA: P = 0.0022, Dunn test: P < 0.05)). These results indicate that CPA had a facilitating effect on memory. We suggest that the fish submitted to telencephalic ablation were able to learn due to the local circuits of the mesencephalon and/or diencephalon and that CPA interferes in these circuits, probably due an anxiolytic-like effect.

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Effects of lesions of amygdaloid nuclei and substantia nigra on aversive responses induced by electrical stimulation of the inferior colliculus

Cited by 94 publications

References 34 publications

Signaled two-way avoidance learning using electrical stimulation of the inferior colliculus as negative reinforcement: effects of visual and auditory cues as warning stimuli

Signaled two-way avoidance learning using electrical stimulation of the inferior colliculus as negative reinforcement: effects of visual and auditory cues as warning stimuli

Apomorphine Enhances Conditioned Responses Induced by Aversive Stimulation of the Inferior Colliculus

Chlorpheniramine facilitates inhibitory avoidance in teleosts submitted to telencephalic ablation

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