Effects of lectins with various carbohydrate binding specificities on lipid metabolism in isolated rat and hamster adipocytes

Unravelling the mechanisms of PFOS toxicity by combining morphological and transcriptomic analyses in zebrafish embryos

“…It is remarkable how interweaved were the observed transcriptomics effects with themselves and with the phenotypic alterations, suggesting a common initial triggering point. For example, the structural and functional diversity of lectins (the above mentioned IPR013320 structural term is a subgroup of them) have been previously studied in teleost fish, showing their involvement not only in the immune response (Vasta et al, 2011), but also in lipid regulation (Cambi et al, 2005;Ng et al, 1989), and that lectin malfunction may result in bent tails and other skeletal muscle problems in zebrafish (Ahmed et al, 2009), which are similar to the ones observed in our exposed animals.…”

Isolation of an N-acetyl-d-glucosamine specific lectin from the rhizomes of Arundo donax with antiproliferative activity

“…The antiinsect activity, particularly in the members of Gramineae, has been reported to be related with such a sugar specificity (Carlini and Geossi-de-Sa, 2002). In general, it may also be mentioned here that most of the GlcNAc specific lectins have also been reported to be antilipolytic and lipogenic (Ng et al, 1989).…”

“…It is their unique ability to recognize and bind to specific carbohydrates without chemically modifying them that makes lectins invaluable tools in biomedical and glycoconjugate research. Some lectins with different carbohydrate-binding specificities have been investigated for their diverse biological activities and functions, which have shown that the N-acetyl-D-glucosamine (GlcNAc) and mannose specific lectins generally manifest potent insulin like activities (Ng et al, 1989). Recently, it has also been reported that the GlcNAc specific lectins exhibit more pronounced antitumor effect on different cancer cell lines in comparison to the other carbohydrate specific lectins tested (Wang et al, 2000).…”

Soy-Induced Fecal Metabolome Changes in Ovariectomized and Intact Female Rats: Relationship with Cardiometabolic Health

“…Little is known about the general health effects induced by increased fucose or how fucose affects adipose tissue, but an L-fucose transporter has been identified in relatively high concentrations in adipose tissue 78 . Notably, fucose-binding lectins show anti-lipolytic activity in isolated rat and hamster adipocytes 79 . Further work is needed to determine whether elevated intestinal fucose might mediate some of the beneficial AT effects of a SOY-diet.…”