Effects of Lead on Electrophoretic Mobility, Membrane Sialic Acid, Deformability and Survival of Rat Erythrocytes.

Terayama, Kazuyuki

doi:10.2486/indhealth.31.113

Cited by 37 publications

(29 citation statements)

References 28 publications

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“…Both parameters are significantly increased. 111 terms of flexibility, this finding is in agreement with that of Chabanel et a1 (21) and was also found in rats experimentally exposed to lead (27). Concerning increased aggregation, no data are available.…”

Section: Discussionsupporting

confidence: 82%

Hemorheology in occupational lead exposure

Osterode

1996

Scand J Work Environ Health

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Objectives Tlle purpose of this investigation was to study hemorheological parameters in occupationally lead exposed men. Material and methods For 15 clinically healthy lead-exposed male subjects [age 34.6 (SD 8) years] the viscous (E') and elastic (E") components of whole blood viscosity corrected for 45% hematocrit were measured for shear rates between 1 . s-I -100 . s-' at 37OC. Moreover, lead concentrations in blood and urine and the deltaaminolevuliilic acid dehydrase level were determined. Fifteen unexposed age-matched men were used as referents.Results The meail lead concentration in the blood and urine of the lead-exposed men was 48.7 (SD 16.2) pg . dl-' and 38.8 (SD 17.1) pg . g creatinine-', respectively. While E" was significantly increased only at low shear rates, E' was elevated throughout the investigated shear range in comparison with the values of the unexposed referents. These results are characteristic of erythrocytes with enhanced rigidity. The aggregation and filtration index of erythrocytes were significantly elevated for the lead-exposed workers. A positive correlation existed between lead in blood and E' or E", whereas 6-aminolevulinic acid dehydrase and E' or E" were inversely correlated. No differences in plasma viscosity or in lipid status could be detected. C O~C~U S~O~Increased blood lead concentrations can be considered an additional risk factor for vascular diseases predisposing towards microvascular occlusion.Key terms blood viscosity, erythrocyte, lead, 6-aminolevulinic acid dehydrase.Approximately 95% of the circulating fraction of lead in the human body is bound to erythrocytes (I). Several

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Section: Discussionsupporting

confidence: 82%

Hemorheology in occupational lead exposure

Osterode

1996

Scand J Work Environ Health

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“…The decreased RBC count depends on dose and duration of lead acetate. A shortening of erythrocyte survival time was also observed in rats exposed to lead (Terayama et al, 1993). The precise mechanism underlying lead toxicity on RBC is still to be defined.…”

Section: Introductionmentioning

confidence: 78%

“…Exposure to lead significantly decreased red blood cell counts, hemoglobin levels and hematocrit values (Terayama, 1993). Anemia accompanying lead poisoning has the inhibitory effects of lead on heme biosynthesis.…”

Section: Introductionmentioning

confidence: 96%

Effects of Garlic (Allium sativum) feed supplement on Hemato-Biochemical properties in broiler chickens with sub-clinical toxicity of lead

Hossain

Mostofa

Alam

et al. 2015

Res. Agric. Livest. Fish.

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The present study was conducted to estimate the garlic feed supplement on hematobiochemical parameters in lead exposed broiler chickens. 350 commercial broiler chickens were grouped into five, as T0, T1, T2, T3 and T4 consisting of 70 birds each, where T0 served as control. T1 was provided with lead acetate @ 100mg/kg body weight, T2 @ 100mg/kg lead acetate + 1% garlic supplement, T3 was fed @ 100mg/kg lead acetate + 2% garlic supplement and T4 @ 100mg/kg lead acetate + 4% garlic supplement .It was observed that Garlic supplementation in feed has got some ability to maintain normal values of erythrocytes, leukocytes, ALT, AST & Cholesterol parameters in spite of treatment with lead acetate. It was also found highly significant (P<0.001) in 2% garlic supplemented group (T3) compared to that of 1% (T2) and 4% (T4) garlic supplemented groups. The mean values of erythrocyte, Hb. and PCV significantly reduced from 2.217±0.020 to 2.062±0.047, 7.697±0.247 to 6.172±0.198 and 25.183±0.8122 to 23.532±1.001, respectively in group T1. The ameliorating effects of garlic in heavy metal lead revealed significantly (P<0.01) increased erythrocyte, hemoglobin and PCV values from 2.16±0.034 to 2.46±0.077, 8.362±0.262 to 10.44±0.26 and 23.64±0.90 to 30.68±0.75 in group T3, respectively. The mean values of ALT, AST and Cholesterol with lead Acetate @ 100mg/kg treatment were significantly (P<0.01) increased from 30.11±1.135 to 36.274±1.192, 51.162±1.422 to 103.641±2.023 and 152.34±17.47 to 364.28±12.33, respectively in T1 group on 42nd Day of treatment. The calculated significant mean values (mg/dl) of ALT, AST and Cholesterol were 24.51±0.63, 57.95±1.68 and 203.62±12.76, respectively in T3 group. The protection action of garlic against lead toxicity could be attributed to the antioxidant action of its sulfhydryl groups. DOI: http://dx.doi.org/10.3329/ralf.v1i1.22364 Res. Agric., Livest. Fish.1(1): 87-96, Dec 2014

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“…Lead could affect RBC membrane flexibility, increase RBC fragility and decrease their mobility [30] leading to hemolysis [31]. In addition lead may induce oxidative stress in RBCs [32].…”

Section: Discussionmentioning

confidence: 99%

Prophylactic Effects of Garlic Oil and Onion Oil Fractions as Compared to Vitamin E on Rats Orally Fed with Lead Acetate Solution

2016

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Heavy metal pollution is a global public health challenge due to its stable and persistent environmental contamination. Of these lead is considered to be one of the most common ubiquitous and industrial pollutants and at low concentration it exerts extensive damages to the tissues. Daily feeding of lead acetate solution (Dose: 10 mg/ kg/day) to normal rats for a month adversely altered the parameters of blood, serum and tissues, viz; RBC, WBC, Hb, ë-ALAD (Delta amino levulinic acid dehydratase), Pb content, lipids, oxidized lipids (TBARS), vitamins C and E and GSH levels and activities of AST, ALT and antioxidant enzymes viz; catalase, GR, Gpx and SOD. In order to study whether antioxidants have any effect to counteract the toxicity of lead we have selected comparatively better active allium fractions for the study viz: polar fraction of garlic (PFG) and polar fraction of onion (PFO). On feeding of these active fractions of garlic and onion oils i.e. their polar fractions and vitamin E (Dose 100 mg/kg/day) separately for a month along with or without lead acetate to rats each nutraceutical and vitamin E counteracted the adverse effects of Pb significantly (p B 0.05). Their effects are in the order of PFG [ PFO [ Vitamin E. All these results point out that garlic and onion oils contain natural disulfoxide compounds which act as antioxidant and anti toxic to lead compounds. Their comparative differences in action may be due to the presence and position of double bonds and disulfide oxide bonds in their molecules. i.e., in PFG the allyl disulfide oxide group is present and in PFO saturated methyl and propyl groups and unsaturated propenyl group are present in place of allyl groups. The former group confers a better antioxidant activity on PFG, while the latter groups confer a lesser activity on PFO.

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Effects of Lead on Electrophoretic Mobility, Membrane Sialic Acid, Deformability and Survival of Rat Erythrocytes.

Cited by 37 publications

References 28 publications

Hemorheology in occupational lead exposure

Hemorheology in occupational lead exposure

Effects of Garlic (Allium sativum) feed supplement on Hemato-Biochemical properties in broiler chickens with sub-clinical toxicity of lead

Prophylactic Effects of Garlic Oil and Onion Oil Fractions as Compared to Vitamin E on Rats Orally Fed with Lead Acetate Solution

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