Effects of Lead on Blood Cells

Aub, Joseph C.; Fairhall, Lawrence T.; Minot, A S; Reznikoff, Paul

doi:10.1097/00005792-192504010-00011

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Hematopoietic Effects1

Erythrocyte Survival and Anemia1

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2013

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“…Environmental and occupational lead poisonings have long been associated with anemia, whose mechanisms are complex and multifactorial. A review by Aub et al (1925) concluded that severe lead poisoning was associated with anemia that was initially due to enhanced destruction of circulating erythrocytes followed by "bone marrow failure". Those and other aspects of the anemia of lead poisoning have been well documented, and their mechanisms are now better understood.…”

Section: Hematopoietic Effectsmentioning

confidence: 99%

“…BLLs were not measured in that landmark study, and the diagnosis of lead poisoning was made by measuring increased coproporphyrin in urine (over 500 µg/L). Heightened osmotic fragility and changes in erythrocyte shapes have long been thought to be responsible for the enhanced erythrocyte destruction; indeed, in experimental animals, removal of the spleen, the organ responsible for erythrocyte sequestration, temporarily reverses the anemia of lead poisoning (Aub et al 1925).…”

Section: Erythrocyte Survival and Anemiamentioning

confidence: 99%

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