Effects of lead exposure on the activation of microglia in mice fed with high‐fat diets

Wu, Lei; Li, Shuang; Pang, Shulan; Zhang, Bo; Wang, Jierui; He, Bin; Lv, Linyi; Wang, Weixuan; Zhao, Na; Zhang, Yanshu

doi:10.1002/tox.23312

Cited by 16 publications

(11 citation statements)

References 54 publications

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“…proved that an astrocyte subset can have the opposite effect. LAMP1 + TRAIL + astrocytes are distributed near the meninges (the membrane surrounding the brain) and can express the lysosomal protein LAMP1 2 and the death receptor ligand TRAIL 3 . TRAIL proteins can induce the death of T cells that promote inflammation and help to limit CNS inflammation.…”

Section: The Role Of the Brain–gut–microbiota Axis In Neuroinflammationmentioning

confidence: 99%

“…Lead has a strong affinity for nerve cells and can cause neurological diseases. Wu et al 2 demonstrated that lead can induce an inflammatory cascade in the CNS by triggering glial cells, disrupting blood-brain barrier (BBB) structure and function, and promoting the release of pro-inflammatory factors. Neuroinflammation triggers neuronal death and leads to neurological damage.…”

Section: Introductionmentioning

confidence: 99%

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Dietary fiber ameliorates lead‐induced gut microbiota disturbance and alleviates neuroinflammation

et al. 2022

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Dietary fiber (DF) is a carbohydrate from the edible part of plants and has the functions of promoting gastrointestinal motility, regulating gut microbiota (GM) and improving health. Lead is a non-essential toxic heavy metal that can accumulate in the environment over time and enter the body through the respiratory tract, skin and gastrointestinal tract. Lead not only causes disturbances in GM but also leads to loss of homeostasis of immune functions, causes neuronal damage and results in neuroinflammation. The scientific literature has reported that DF had anti-inflammatory activity as a natural product. This review highlights the role of DF and its metabolic products in alleviating lead-induced neuroinflammation by inducing changes in the species and quantity of GM and regulating the immune system, providing a potential dietary protective strategy for lead-induced disease.

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Section: The Role Of the Brain–gut–microbiota Axis In Neuroinflammationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dietary fiber ameliorates lead‐induced gut microbiota disturbance and alleviates neuroinflammation

et al. 2022

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“…HM,s including Cd, Mn, Hg, As, and Ni, induce impairment of astrocyte functions and direct astrocytic cell death [ 61 ]. Activation of microglia upon exposure to Pb has been shown in mice [ 62 ]. Moreover, the microglia are able to amplify inflammatory activation of astrocytes in Mn-induced neurotoxicity [ 63 ].…”

Section: Mechanisms Of Toxicity Induced By Toxic Metals In Ndmentioning

confidence: 99%

Neuron Protection by EDTA May Explain the Successful Outcomes of Toxic Metal Chelation Therapy in Neurodegenerative Diseases

Ferrero

2022

Biomedicines

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Many mechanisms have been related to the etiopathogenesis of neurodegenerative diseases (NDs) such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson’s disease, and Alzheimer’s disease. In this context, the detrimental role of environmental agents has also been highlighted. Studies focused on the role of toxic metals in the pathogenesis of ND demonstrate the efficacy of treatment with the chelating agent calcium disodium ethylenediaminetetraacetic acid (EDTA) in eliminating toxic metal burden in all ND patients, improving their symptoms. Lead, cadmium, aluminum, nickel, and mercury were the most important toxic metals detected in these patients. Here, I provide an updated review on the damage to neurons promoted by toxic metals and on the impact of EDTA chelation therapy in ND patients, along with the clinical description of a representative case.

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“…Toxic metals are among the most important causes of environmental pollution 1–5 . Lead (Pb) is among the environmentally polluting and toxic metals 6–10 .…”

Section: Introductionmentioning

confidence: 99%

Effects of sinapic acid on lead acetate‐induced oxidative stress, apoptosis and inflammation in testicular tissue

Tuncer

Akarsu

Küçükler

et al. 2023

Environmental Toxicology

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In this study, the effect of lead acetate (PbAc) and sinapic acid (SNP) administration on oxidative stress, apoptosis, inflammation, sperm quality and histopathology in testicular tissue of rats was tried to be determined. PbAc was administered at a dose of 30 mg/kg/bw for 7 days to induce testicular toxicity in rats. Oral doses of 5 and 10 mg/kg/bw SNP were administered to rats for 7 days after PbAc administration. According to our findings, while PbAc administration increased MDA content in rats, it decreased GPx, SOD, CAT activity and GSH content. NF‐kB, IL‐1β, TNF‐α, and COX‐2, which are among the inflammation parameters that increased due to PbAc, decreased with the administration of SNP. Nrf2, HO‐1, and NQO1 mRNA transcript levels decreased with PbAc, but SNP treatments increased these mRNA levels in a dose‐dependent manner. RAGE and NLRP3 gene expression were upregulated in PbAc treated rats. MAPK14, MAPK15, and JNK relative mRNA levels decreased with SNP treatment in PbAc treated rats. While the levels of apoptosis markers Bax, Caspase‐3, and Apaf‐1 increased in rats treated with PbAc, the level of Bcl‐2 decreased, but SNP inhibited this apoptosis markers. PbAc caused histopathological deterioration in testis tissue and negatively affected spermatogenesis. When the sperm quality was examined, the decrease in sperm motility and spermatozoon density caused by PbAc, and the increase in the ratio of dead and abnormal spermatozoa were inhibited by SNP. As a result, while PbAc increased apoptosis and inflammation by inducing oxidative stress in testicles, SNP treatment inhibited these changes and increased sperm quality.

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Effects of lead exposure on the activation of microglia in mice fed with high‐fat diets

Cited by 16 publications

References 54 publications

Dietary fiber ameliorates lead‐induced gut microbiota disturbance and alleviates neuroinflammation

Dietary fiber ameliorates lead‐induced gut microbiota disturbance and alleviates neuroinflammation

Neuron Protection by EDTA May Explain the Successful Outcomes of Toxic Metal Chelation Therapy in Neurodegenerative Diseases

Effects of sinapic acid on lead acetate‐induced oxidative stress, apoptosis and inflammation in testicular tissue

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