Effects of lead and cadmium co-exposure on bone mineral density in a Chinese population

Chen, Xiao; Wang, Keyue; Wang, Zhongqiu; Gan, Caohui; He, Ping; Liang, Yong; Jin, Taiyi; Zhu, Guoying

doi:10.1016/j.bone.2014.02.017

Cited by 73 publications

(37 citation statements)

References 38 publications

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“…Investigations that specifically examined exposed populations such as those in polluted areas [18] or those working in the mining industry [17] saw much larger effect sizes than those observed here. In fact, Brito et al modeled exposure data and showed that half-lives for bone lead in the cortex and trabeculae are longer for individuals who are exposed to lead over a longer period (half-life: 47.5 ± 2.3 years) compared to those with acute exposure (half-life: 6.5 ± 0.7 years) [29].…”

Section: Exposure To Lead and Bone Lead Measurementscontrasting

confidence: 67%

“…However, no study has examined the relationship between bone lead content and structural properties of bone. Although two studies of exposed individuals showed that blood lead content was associated with a lower aBMD at the lumbar spine [17,18], two other studies did not reveal a significant relationship between blood lead and aBMD [16,19]. The conflicting evidence that blood lead may have an effect on aBMD may be explained by the cohort's level of exposure.…”

Section: Introductionmentioning

confidence: 99%

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Bone lead (Pb) content at the tibia is associated with thinner distal tibia cortices and lower volumetric bone density in postmenopausal women

Wong

Beattie

Bhargava

et al. 2015

Bone

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Conflicting evidence suggests that bone lead or blood lead may reduce areal bone mineral density (BMD). Little is known about how lead at either compartment affects bone structure. This study examined postmenopausal women (N = 38, mean age 76 ± 8, body mass index (BMI): 26.74 ± 4.26 kg/m 2 ) within the Hamilton cohort of the Canadian Multicentre Osteoporosis Study (CaMos), measuring bone lead at 66% of the non-dominant leg and at the calcaneus using 109 Cadmium X-ray fluorescence. Volumetric BMD and structural parameters were obtained from peripheral quantitative computed tomography images (200 μm in-plane resolution, 2.3 ± 0.5 mm slice thickness) of the same 66% site and of the distal 4% site of the tibia length. Blood lead was measured using atomic absorption spectrometry and blood-to-bone lead partition coefficients (P BB , log ratio) were computed. Multivariable linear regression examined each of bone lead at the 66% tibia, calcaneus, blood lead and P BB as related to each of volumetric BMD and structural parameters, adjusting for age and BMI, diabetes or antiresorptive therapy. Regression coefficients were reported along with 95% confidence intervals. Higher amounts of bone lead at the tibia were associated with thinner distal tibia cortices (−0.972 (−1.882, −0.061) per 100 μg Pb/g of bone mineral) and integral volumetric BMD (−3.05 (−6.05, −0.05) per μg Pb/g of bone mineral). A higher P BB was associated with larger trabecular separation (0.115 (0.053, 0.178)), lower trabecular volumetric BMD (−26.83 (−50.37, −3.29)) and trabecular number (−0.08 (−0.14, −0.02)), per 100 μg Pb/g of bone mineral after adjusting for age and BMI, and remained significant while accounting for diabetes or use of antiresorptives. Total lead exposure activities 8.29 (0.11, 16.48)) and remained significant after age and antiresorptives-adjustment. Lead accumulated in bone can have a mild insult on bone structure; but greater partitioning of lead in blood versus bone revealed more dramatic effects on both microstructure and volumetric BMD.

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Section: Exposure To Lead and Bone Lead Measurementscontrasting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Bone lead (Pb) content at the tibia is associated with thinner distal tibia cortices and lower volumetric bone density in postmenopausal women

Wong

Beattie

Bhargava

et al. 2015

Bone

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“…More numerous epidemiological data provide evidence that important environmental risk factors for the increasing incidence of osteoporosis are toxic heavy metals, including cadmium (Cd) [1][2][3][8][9][10]. Due to the wide distribution of this metal in the environment and food pollution, as well as its presence in the tobacco smoke, the whole population is exposed to this metal during the lifetime [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…Due to the wide distribution of this metal in the environment and food pollution, as well as its presence in the tobacco smoke, the whole population is exposed to this metal during the lifetime [8][9][10][11][12]. Bone damage is one of the main unfavourable health effects of long-term exposure to this xenobiotic in both human [1,[8][9][10][11][12] and experimental animals [13][14][15][16][17][18][19]. We have reported, on a rat model of environmental human exposure to Cd, that this metal disturbs bone metabolism and weakens biomechanical properties of long bones and lumbar spine vertebral bodies, and may even result in femoral neck and vertebral fractures [13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

“…We have reported, on a rat model of environmental human exposure to Cd, that this metal disturbs bone metabolism and weakens biomechanical properties of long bones and lumbar spine vertebral bodies, and may even result in femoral neck and vertebral fractures [13][14][15][16][17][18]. In recent years, more and more numerous epidemiological data have shown that even low-level lifetime exposure to this heavy metal may decrease bone mineral density (BMD) and contribute to osteoporosis with increased risk of bone fracture in the general population [1,[8][9][10]. Moreover, the forecasts indicate that exposure of the general population to this xenobiotic will increase in the future decades [11].…”

Section: Introductionmentioning

confidence: 99%

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Protective Effect of Chokeberry (<em>Aronia melanocarpa </em>L.) Extract Against Cadmium Impact on the Biomechanical Properties of the Femur: A Study in a Rat Model of Low and Moderate Lifetime Women Exposure to this Heavy Metal

Brzóska

Roszczenko

Rogalska

et al. 2017

Preprint

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The hypothesis that consumption of Aronia melanocarpa berries (chokeberries) extract, recently reported by us to improve bone metabolism in female rats at low-level and moderate chronic exposure to cadmium (1 and 5 mg Cd/kg diet for up to 24 months), may increase the bone resistance to fracture was investigated. Biomechanical properties of the neck (bending test with vertical head loading) and diaphysis (three-point bending test) of the femur of rats administered 0.1% aqueous chokeberry extract (65.74% of polyphenols) or/and Cd in the diet (1 and 5 mg Cd/kg) for 3, 10, 17, and 24 months were evaluated. Moreover, procollagen I was assayed in the bone tissue. The low-level and moderate exposure to Cd decreased procollagen I concentration in the bone tissue and weakened biomechanical properties of the femoral neck and diaphysis. Chokeberry extract administration under the exposure to Cd improved the bone collagen biosynthesis and femur biomechanical properties. The results allow for the conclusion that consumption of chokeberry products under exposure to Cd may improve the bone biomechanical properties and protect from fracture. This study provides support for Aronia melanocarpa berries being a promising natural agent for the skeleton protection under low-level and moderate chronic exposure to Cd.

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Co‐exposure of cadmium and lead on bone health in a southwestern Chinese population aged 40‐75 years

Yan

et al. 2019

J of Applied Toxicology

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Both cadmium (Cd) and lead (Pb) are associated with bone health, but studies exploring the effects of Cd and Pb co‐exposure on bone health are rare. This study aimed to assess the interactive effects of Cd and Pb co‐exposure on bone health. In total, 799 participants, living in the targeted areas (located in southwestern China) for more than 15 years, aged 40‐75 years, and subsisted on homegrown rice and vegetables were investigated. Cd and Pb levels in urine and blood samples, as well as bone mineral density, T‐ and Z‐score were determined. After being adjusted for covariates, the T‐score was negatively correlated with blood Pb in men (P < .05); for women and non‐smoking women, the T‐score was negatively correlated with urinary Pb (P < .05). Moreover, after being adjusted for covariates, the Z‐score was negatively correlated with urinary Pb in non‐smoking women (P < .05). No positive association of prevalence of osteoporosis with Cd and Pb exposure was found. However, at an additive scale, positive interactions of urinary Cd and Pb on the prevalence of osteoporosis for women and non‐smoking women, and the same interactions to blood Cd and Pb for men were found. There was also a positive interaction of urinary Cd and Pb for women at a multiplicative scale. This study suggests Cd and Pb exposure could exert detrimental effects on bone health, with possible underlying interactions. Nevertheless, more studies are needed to explore the interactive effects of heavy metal co‐exposure.

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Effects of lead and cadmium co-exposure on bone mineral density in a Chinese population

Cited by 73 publications

References 38 publications

Bone lead (Pb) content at the tibia is associated with thinner distal tibia cortices and lower volumetric bone density in postmenopausal women

Bone lead (Pb) content at the tibia is associated with thinner distal tibia cortices and lower volumetric bone density in postmenopausal women

Protective Effect of Chokeberry (<em>Aronia melanocarpa </em>L.) Extract Against Cadmium Impact on the Biomechanical Properties of the Femur: A Study in a Rat Model of Low and Moderate Lifetime Women Exposure to this Heavy Metal

Co‐exposure of cadmium and lead on bone health in a southwestern Chinese population aged 40‐75 years

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