Effects of landiolol on QT interval and QT dispersion during induction of anesthesia using computerized measurement

Kaneko, Mizue; Yamaguchi, Shigeki; Hamaguchi, Shinsuke; Egawa, Hirotoshi; Fujii, Koichi; Ishikawa, Kazuyoshi; Kitajima, Toshimitsu; Minami, Junichi

doi:10.1016/j.jclinane.2008.12.027

Cited by 16 publications

(8 citation statements)

References 39 publications

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“…Além disso, a incidência de arritmias após a intubação também diminuiu com esmolol. Recentemente, Kaneko et al 32 investigaram o efeito de landiolol, um antagonista do receptor adrenérgico-␤ 1 de ação ultracurta, sobre o intervalo QT e a dispersão do QT. Semelhantemente aos nossos resultados, os autores descobriram que landiolol previne o aumento de QT, QTc, DQT e DQTc durante e após a intubação traqueal.…”

Section: Discussionunclassified

Efeito de esmolol sobre o intervalo QT corrigido e alterações da dispersão do intervalo QT corrigido observadas durante a indução da anestesia em pacientes hipertensos que receberam um inibidor da enzima conversora de angiotensina

Çeker

Takmaz

Baltaci

et al. 2015

Brazilian Journal of Anesthesiology

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Endotracheal intubation was found to prolong corrected-QT interval and corrected-QT interval dispersion, and increase the heart rate during anesthesia induction with propofol in hypertensive patients using angiotensin converting enzyme inhibitors. These effects were prevented with esmolol (500mcg/kg bolus, followed by 100mcg/kg/min infusion). During induction, the blood pressure tends to decrease with esmolol where care is needed.

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Section: Discussionunclassified

Efeito de esmolol sobre o intervalo QT corrigido e alterações da dispersão do intervalo QT corrigido observadas durante a indução da anestesia em pacientes hipertensos que receberam um inibidor da enzima conversora de angiotensina

Çeker

Takmaz

Baltaci

et al. 2015

Brazilian Journal of Anesthesiology

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“…25) Landiolol reduces QTc interval, thus reducing the risk of cardiac arrhythmias during induction of anesthesia. 27) In all our patients, the spatial QRS-T angle decreased and QTc interval shortened following landiolol and levosimendan infusion. Moreover, we did not observe any life-threatening cardiac arrhythmias in these patients.…”

Section: Discussionmentioning

confidence: 56%

Successful Combination of Landiolol and Levosimendan in Patients with Decompensated Heart Failure

Dąbrowski¹,

Siwicka-Gieroba²,

Piasek³

et al. 2020

Int. Heart J.

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Tachycardia and supraventricular tachyarrhythmias often impair cardiovascular capacity in patients with decompensated heart failure (dHF) treated with inotropes. Normalization of heart rhythm or rate typically improves diastolic filling and stroke volume (SV). Thus, isochronal administration of an ultra-short-acting and highly selective β1-blockers, such as landiolol, along with inotropic calcium-sensitizer medications, such as levosimendan, could benefit patients with dHF.We present a case series of three patients with severe dHF and low ejection fraction who were successfully treated with a combination of landiolol and levosimendan. The co-administration of landiolol and levosimendan was well tolerated, improved cardiac function, normalized SV, and enabled the reduction of norepinephrine dosing in all patients. Additionally, the combination improved the vectorcardiographic spatial QRS-T angle and decreased the corrected QT interval. All patients were successfully discharged from the intensive care unit (ICU).A combination of levosimendan and landiolol was safe and well-tolerated. This combination may be a new option for successful treatment of patients with acute dHF complicated by sinus or supraventricular tachycardias.(Int Heart J 2020; 61: 384-389)

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“…The reduction of HR itself showed no apparent cardioprotective effect [20]. Kaneko et al [21] showed that the stress during induction of anesthesia and surgical procedure increased QTD and the infusion of landiolol antagonized the change. The periprocedural risk of cardiac arrhythmias may be reduced by landiolol [21].…”

Section: Discussionmentioning

confidence: 99%

Continuous administration of landiolol reduced QT dispersion in postoperative patients

Suzuki

Numaguchi

Adachi

et al. 2014

Journal of Clinical Anesthesia

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Effects of landiolol on QT interval and QT dispersion during induction of anesthesia using computerized measurement

Cited by 16 publications

References 39 publications

Efeito de esmolol sobre o intervalo QT corrigido e alterações da dispersão do intervalo QT corrigido observadas durante a indução da anestesia em pacientes hipertensos que receberam um inibidor da enzima conversora de angiotensina

Efeito de esmolol sobre o intervalo QT corrigido e alterações da dispersão do intervalo QT corrigido observadas durante a indução da anestesia em pacientes hipertensos que receberam um inibidor da enzima conversora de angiotensina

Successful Combination of Landiolol and Levosimendan in Patients with Decompensated Heart Failure

Continuous administration of landiolol reduced QT dispersion in postoperative patients

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