Effects of landiolol on hemodynamic response and seizure duration during electroconvulsive therapy

Nomoto, Koichi; Suzuki, Takashi; Serada, Kazuyuki; Oe, Katsunori; Yoshida, Tatsuya; Yamada, Sayoko

doi:10.1007/s00540-006-0401-1

Cited by 15 publications

(11 citation statements)

References 26 publications

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“…The hyperdynamic state induced by sympathetic activation can be prevented by ganglion-blockers [46], betablockers [47][48][49][50][51][52][53][54][55][56][57][58][59]67,77], alpha-1 and alpha2-agonists [60][61][62][63][64][65][66], Ca2+-channel antagonists [68][69][70], nitrates [71][72][73][74][75][76] or local anesthetics [78]. Rapid, short-acting opioid [79][80][81] analgesics also possess sympatholytic effects and have recently been investigated as adjuvants during ECT.…”

Section: Drugs Used For Hemodynamic Stabilizationmentioning

confidence: 99%

Anesthetic Considerations for Electroconvulsive Therapy-Especially Hemodynamic and Respiratory Management

Y¹

2009

CPSR

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Recent guidelines have stated that anesthesia for electroconvulsive therapy (ECT) should be administered by specially trained anesthesiologists. Physicians who perform ECT should have sufficient knowledge about hemodynamics as well as the physiological and pharmacologically unique effects of ECT. Electrical currents during ECT stimulate the autonomic nervous system and provoke unique hemodynamic changes in the systemic and cerebral circulation. Excessive alterations in heart rate, blood pressure, and cardiac functions should be prevented by medications with anticholinergic and antihypertensive effects. Ventilation should be adequately maintained to ensure efficacy of the therapy and to stabilize hemodynamics immediately after the electrical stimulation. Although reports of serious complications with this therapy are not frequent, patients with ischemic heart disease or cerebrovascular disease must be managed with special care to prevent myocardial infarction or neurological disorders. Appropriate physical management by physicians greatly contributes to the safe establishment of ECT under muscle relaxation. To maintain social confidence in this procedure and to further refine this therapy, physicians should play an essential role in both the clinical activities and laboratory research of ECT.

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Section: Drugs Used For Hemodynamic Stabilizationmentioning

confidence: 99%

Anesthetic Considerations for Electroconvulsive Therapy-Especially Hemodynamic and Respiratory Management

Y¹

2009

CPSR

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“…and 0.5 mg/kg landiolol, whereas increase in mean BP was improved by esmolol but not by landiolol [16]. Nomoto et al [9] showed that 0.1 and 0.2 mg/kg bolus doses of landiolol were found to be effective in attenuating the hemodynamic responses to ECT. In addition, they concluded that because the 0.2 mg/kg dose of landiolol causes a shorter seizure duration, and the hemodynamic effects of the 0.1-and 0.2-mg/kg dose of landiolol after ECT were similar, pretreatment with a 0.1 mg/kg landiolol bolus dose was suitable for attenuation of hemodynamic alterations during ECT.…”

Section: Discussionmentioning

confidence: 97%

“…This agent is approximately nine times more potent in beta-1 blocking activity and eight times more cardioselective than esmolol [8]. Nomoto et al [9] demonstrated the efficacy of landiolol for stabilizing systemic hemodynamics during ECT. We previously characterized the time course of changes in left ventricular (LV) systolic function during ECT using an echocardiographic automated border-detection system [10,11].…”

Section: Introductionmentioning

confidence: 97%

Effects of landiolol on left ventricular function during electroconvulsive therapy: a transthoracic echocardiographic study

et al. 2010

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The purpose of this study was to examine the effects of landiolol on left ventricular (LV) systolic function, using transthoracic echocardiography, during electroconvulsive therapy (ECT). Fourteen patients undergoing ECT were studied. Bilateral ECT was performed after administration of thiopentone (2 mg/kg), succinylcholine (1 mg/kg), and initiation of assisted mask ventilation with 100% oxygen. Patients received a bolus injection of landiolol (0.125 mg/kg) or saline immediately after anesthetic induction and prior to electrical shock. LV systolic function was examined by transthoracic echocardiography prior to anesthetic induction, throughout the ECT procedure, and for 10 min after the seizure. Electrical shock resulted in a significant decrease in fractional area change (FAC) when compared with the awake condition in the control group [FAC when awake: 48 +/- 3%; 1 min after ECT: 38 +/- 4%*; 2 min after ECT: 36 +/- 4%*; 3 min after ECT: 40 +/- 3%*; mean +/- standard deviation, *p < 0.05 compared with awake]. Landiolol infusion stabilized systemic hemodynamics and LV systolic function. The study demonstrated that landiolol is a suitable agent to minimize hemodynamic changes and transthoracic echocardiographic variability after ECT.

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“…39 With landiolol of more than 0.125 mg/kg, significant effects were found in reducing the increase in heart rate during electroconvulsive therapy. [40][41][42][43][44] Effects of heart rate on image quality and radiation exposure of coronary CT angiography…”

Section: Clinical Use Of Landiololmentioning

confidence: 99%

Clinical utility of landiolol for use in coronary CT angiography

Tomizawa¹,

Hayakawa²,

Inoh³

et al. 2015

RRCC

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Although remarkable advancement in computed tomography (CT) has been achieved, heart rate control is important to maintain an optimal image quality in coronary CT angiography. Oral or intravenous β-blockers are used as premedication for this purpose. Landiolol was developed as a β-blocker with very high cardioselectivity (β1/β2 =255) and short half-life (4 minutes). In this review, we report the pharmacological features and usage of landiolol and also its effects on heart rate and image quality in coronary CT angiography. In addition, we discuss the safety of landiolol.

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Effects of landiolol on hemodynamic response and seizure duration during electroconvulsive therapy

Abstract: As the landiolol dose of 0.2 mg x kg(-1) caused shorter seizure duration, and because the hemodynamic effects after ECT of the 0.1 mg x kg(-1) and 0.2 mg x kg(-1) doses were similar, it was concluded that a 0.1 mg x kg(-1) landiolol bolus was the appropriate dose pretreatment before ECT.

Cited by 15 publications

References 26 publications

Anesthetic Considerations for Electroconvulsive Therapy-Especially Hemodynamic and Respiratory Management

Anesthetic Considerations for Electroconvulsive Therapy-Especially Hemodynamic and Respiratory Management

Effects of landiolol on left ventricular function during electroconvulsive therapy: a transthoracic echocardiographic study

Clinical utility of landiolol for use in coronary CT angiography

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