Effects of Lactobacillus helveticus on murine behavior are dependent on diet and genotype and correlate with alterations in the gut microbiome

Ohland, Christina; Kish, Lisa; Bell, Haley; Thiesen, Aducio; Hotte, Naomi; Pankiv, Evelina; Madsen, Karen

doi:10.1016/j.psyneuen.2013.02.008

Cited by 242 publications

(151 citation statements)

References 48 publications

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“…Wild-type mice fed a chow-based diet and provided the probiotic Lactobacillus helveticus exhibited a decrease in anxiety-like behaviors (Ohland et al, 2013). As discussed previously, treatment of the MIA mouse model for ASD with the probiotic B. fragilis improved the mucosal barrier and gut dysbiosis, mitigated elevations in several metabolites associated with ASD, and abolished ASD-like behavioral disruptions (Hsiao et al, 2013).…”

Section: Therapeutic Modulation Of Gut Dysbiosis and Asdmentioning

confidence: 68%

Microbiome Disturbances and Autism Spectrum Disorders

2015

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Autism spectrum disorders (ASDs) are considered a heterogenous set of neurobehavioral diseases, with the rates of diagnosis dramatically increasing in the past few decades. As genetics alone does not explain the underlying cause in many cases, attention has turned to environmental factors as potential etiological agents. Gastrointestinal disorders are a common comorbidity in ASD patients. It was thus hypothesized that a gut-brain link may account for some autistic cases. With the characterization of the human microbiome, this concept has been expanded to include the microbiota-gut-brain axis. There are mounting reports in animal models and human epidemiologic studies linking disruptive alterations in the gut microbiota or dysbiosis and ASD symptomology. In this review, we will explore the current evidence that gut dysbiosis in animal models and ASD patients correlates with disease risk and severity. The studies to date have surveyed how gut microbiome changes may affect these neurobehavioral disorders. However, we harbor other microbiomes in the body that might impact brain function. We will consider microbial colonies residing in the oral cavity, vagina, and the most recently discovered one in the placenta. Based on the premise that gut microbiota alterations may be causative agents in ASD, several therapeutic options have been tested, such as diet modulations, prebiotics, probiotics, synbiotics, postbiotics, antibiotics, fecal transplantation, and activated charcoal. The potential benefits of these therapies will be considered. Finally, the possible mechanisms by which changes in the gut bacterial communities may result in ASD and related neurobehavioral disorders will be examined.

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Section: Therapeutic Modulation Of Gut Dysbiosis and Asdmentioning

confidence: 68%

Microbiome Disturbances and Autism Spectrum Disorders

2015

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“…29,37,38 Two studies used Lactobacillus rhamnosus but only one showed reduced anxiety behaviors. 23,35 Two studies using Lactobacillus plantarum also found alleviated anxiety levels in mice after the intervention.…”

Section: Anxietymentioning

confidence: 99%

“…9,29,30,35,37,45,[78][79][80][81][82] In humans, we are not able to adapt most of these models for ethical reasons. Ten of the animal studies included in our review used probiotics in animals whose health state had been disturbed by various manipulations, which included antibiotic treatment, gene knockout, inflammation, infection, maternal immune activation, hyperammonemia, and diabetic induction, and depression induced by myocardial infarction.…”

Section: Translation Of Animal Studiesmentioning

confidence: 99%

Effect of Probiotics on Central Nervous System Functions in Animals and Humans: A Systematic Review

Wang

Lee

Braun

et al. 2016

J Neurogastroenterol Motil

265

195

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To systematically review the effects of probiotics on central nervous system function in animals and humans, to summarize effective interventions (species of probiotic, dose, duration), and to analyze the possibility of translating preclinical studies. Literature searches were conducted in Pubmed, Medline, Embase, and the Cochrane Library. Only randomized controlled trials were included. In total, 38 studies were included: 25 in animals and 15 in humans (2 studies were conducted in both). Most studies used Bifidobacterium (eg, B. longum, B. breve, and B. infantis) and Lactobacillus (eg, L. helveticus, and L. rhamnosus), with doses between 10 9 and 10 10 colonyforming units for 2 weeks in animals and 4 weeks in humans. These probiotics showed efficacy in improving psychiatric disorderrelated behaviors including anxiety, depression, autism spectrum disorder (ASD), obsessive-compulsive disorder, and memory abilities, including spatial and non-spatial memory. Because many of the basic science studies showed some efficacy of probiotics on central nervous system function, this background may guide and promote further preclinical and clinical studies. Translating animal studies to human studies has obvious limitations but also suggests possibilities. Here, we provide several suggestions for the translation of animal studies. More experimental designs with both behavioral and neuroimaging measures in healthy volunteers and patients are needed in the future.

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“…The mechanisms by which probiotics exert their influence on the brain are not yet fully understood, but likely involve multiple pathways between brain, gut, and immune system. Lactobacillus and Bifidobacterium species are key components in probiotics, and treatment with beneficial strains of these species have anxiolytic effects and can normalize behavioral phenotypes in animal anxiety models [16]. The anxiolytic effects may involve activating vagal pathways for gut-brain communication [17].…”

Section: Probioticsmentioning

confidence: 99%

Gut Microbiota and Anxiety: An Exploration of Key Findings

Ding¹

2017

J Depress Anxiety

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Effects of Lactobacillus helveticus on murine behavior are dependent on diet and genotype and correlate with alterations in the gut microbiome

Cited by 242 publications

References 48 publications

Microbiome Disturbances and Autism Spectrum Disorders

Microbiome Disturbances and Autism Spectrum Disorders

Effect of Probiotics on Central Nervous System Functions in Animals and Humans: A Systematic Review

Gut Microbiota and Anxiety: An Exploration of Key Findings

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