Effects of lacidipine on vascular responses in patients with coronary artery disease

Bae, Jang–Ho; Bassenge, E.; Lim, Dong Mee; Synn, Yi-Chul; Kim, Ki‐Young; Schwemmer, Michael

doi:10.1016/j.ijcard.2004.03.046

Cited by 8 publications

(5 citation statements)

References 22 publications

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“…In this study by contrast, the levels of hs-CRP did not change significantly. This discrepant result was consistent with that of a previous study in which patients with coronary artery disease had significantly reduced carotid IMT without a significant change in hs-CRP levels after 6 months of lacidipine treatment 27). This discrepancy between hs-CRP and MCP-1 has also been demonstrated in other studies of angiotensin receptor blockers 28)…”

Section: Discussionsupporting

confidence: 91%

Effect of Lacidipine on Blood Pressure and Endothelial Function in Mild-to-Moderate Essential Hypertension Patients With Diabetes in Korea

Kim

Lee

et al. 2010

Korean Circ J

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Background and ObjectivesThe aim of this study was to evaluate the efficacy of lacidipine in reducing blood pressure (BP) and to determine its effect on endothelial function in mild-to-moderate hypertensive patients with type 2 diabetes mellitus (DM).Subjects and MethodsThis was a prospective, multicenter, open-label, single-arm study, enrolling 290 patients with mild-to-moderate hypertension and type 2 DM. Patients were initially treated with 2 mg lacidipine orally once daily for 4 weeks, which was then increased as necessary every 4 weeks to a maximal dose of 6 mg daily. The primary endpoint was the mean change in systolic blood pressure (SBP) from baseline after 12 weeks of treatment. Secondary endpoints included mean changes in diastolic blood pressure (DBP), flow-mediated vasodilatation (FMD), and serum concentrations of biochemical markers such as high-sensitivity C-reactive protein (hs-CRP), monocyte chemo-attractant protein-1 (MCP-1), matrix metalloproteinase-9 (MMP-9), and plasminogen activator inhibitor-1 (PAI-1).ResultsLacidipine treatment significantly reduced SBP by -13.4±13.0 mmHg (p<0.001) and DBP by -6.2±9.3 mmHg (p<0.001). Lacidipine treatment did not improve endothelial-dependent vasodilatation, despite significantly improved nitroglycerin-induced, endothelial-independent vasodilatation. MCP-1 levels significantly decreased from 283.66±110.08 pg/mL to 257.83±100.23 pg/mL (p<0.001); whereas there were no significant changes in the levels of hs-CRP, MMP-9, or PAI-1.ConclusionTwelve weeks of treatment with lacidipine was effective and well tolerated in mild-to-moderate hypertensive patients with type 2 DM. In spite of inducing a significant reduction in MCP-1 levels, lacidipine did not improve endothelial function.

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Section: Discussionsupporting

confidence: 91%

Effect of Lacidipine on Blood Pressure and Endothelial Function in Mild-to-Moderate Essential Hypertension Patients With Diabetes in Korea

Kim

Lee

et al. 2010

Korean Circ J

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“…Our search strategy identified 31 randomized trials on the CIMT effects of antihypertensive drugs (). There were 4 open studies and 27 double‐blind trials [7,8,11,12,15–40]. All of these studies involved at least one CIMT measurement at the common carotid artery, and many also involved measurements at the internal carotid artery and bifurcation.…”

Section: Resultsmentioning

confidence: 99%

Do all antihypertensive drugs improve carotid intima‐media thickness? A network meta‐analysis of randomized controlled trials

Tropeano

Saleh

Hawajri

et al. 2011

Fundamemntal Clinical Pharma

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The many clinical trials investigating the effect of various antihypertensive drugs on carotid intima-media thickness (CIMT) produced conflicting results. We used meta-analysis to evaluate CIMT changes and network meta-analysis to rank drugs according to the magnitude of these changes. We identified 31 randomized controlled trials listed in three databases as of January 2008. Using a random-effects model, we found a significant CIMT decrease with antihypertensive drugs compared to placebo (-0.10 [-0.16; -0.04]). Overall effect sizes vs. placebo were significant for angiotensin-converting enzyme (ACE) inhibitors (-0.08 [-0.14; -0.02]), and a trend was found for beta-blockers (-0.09 [-0.19; 0.01]). The data did not allow other direct comparisons vs. placebo. Significant benefits were found for calcium-channel blockers (CCBs) compared to both ACE inhibitors (0.37 [0.20; 0.54]), as well as for angiotensin II receptor blockers (ARBs) compared to beta-blockers (0.42 [0.29; 0.55]). Diuretics were less efficient than CCBs (-0.09 [-0.16; -0.02]). Indirect comparisons with network meta-analysis showed significant effects of CCBs and ARBs vs. placebo (both P < 0.05) and vs. diuretics (both P < 0.001). The CIMT decrease with ACE inhibitors and beta-blockers was greater than with diuretics (both P < 0.05) but was not different from the placebo effect. In subgroup analyses, significant benefits occurred with lower baseline CIMT values and shorter treatment durations but were unrelated to the size of the blood pressure decrease. In conclusion, among antihypertensive drugs, CCBs and ARBs have the greatest effect on CIMT.

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“…13 To estimate the reliability of this method of determining thickness of the layers, the relationship between the IMT value determined by this method and that determined by commercial software (M'ATH Version 2.01; Metris Inc, Argenteuil, France) was evaluated for all 150 CCA images.…”

Section: Validation Of It Mt and Imtmentioning

confidence: 99%

Individual Measurement and Significance of Carotid Intima, Media, and Intima–Media Thickness by B-Mode Ultrasonographic Image Processing

Bae

Kim

Rihal³

et al. 2006

ATVB

Self Cite

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Objective-We assessed the clinical significance of intima (IT), media (MT), and intima-media (IMT) thickness of the common carotid artery using B-mode ultrasonographic image processing. Methods and Results-One hundred seventy consecutive patients underwent common carotid artery scanning using high-resolution ultrasonography. A total of 150 patients could be analyzed off-line using ultrasonographic image processing, devised for individual measurement of IT, MT, and IMT. By univariate analysis, IT (range, 0.27 to 0.41 mm) was associated with age, whereas MT (range, 0.27 to 0.74 mm) and IMT (range, 0.49 to 1.12 mm) were associated with age, fibrinogen, and creatinine. Among atherosclerosis risk factors, hypertension was associated with thickness of all 3 layers, whereas smoking was associated with IT only. By multivariate analysis, IT was associated with age, hypertension, and smoking, whereas MT and IMT were associated with age, hypertension, and blood urea nitrogen level. Conclusions-Carotid

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Effects of lacidipine on vascular responses in patients with coronary artery disease

Cited by 8 publications

References 22 publications

Effect of Lacidipine on Blood Pressure and Endothelial Function in Mild-to-Moderate Essential Hypertension Patients With Diabetes in Korea

Effect of Lacidipine on Blood Pressure and Endothelial Function in Mild-to-Moderate Essential Hypertension Patients With Diabetes in Korea

Do all antihypertensive drugs improve carotid intima‐media thickness? A network meta‐analysis of randomized controlled trials

Individual Measurement and Significance of Carotid Intima, Media, and Intima–Media Thickness by B-Mode Ultrasonographic Image Processing

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Effects of lacidipine on vascular responses in patients with coronary artery disease

Cited by 8 publications

References 22 publications

Effect of Lacidipine on Blood Pressure and Endothelial Function in Mild-to-Moderate Essential Hypertension Patients With Diabetes in Korea

Effect of Lacidipine on Blood Pressure and Endothelial Function in Mild-to-Moderate Essential Hypertension Patients With Diabetes in Korea

Do all antihypertensive drugs improve carotid intima‐media thickness? A network meta‐analysis of randomized controlled trials

Individual Measurement and Significance of Carotid Intima, Media, and Intima–Media Thickness by B-Mode Ultrasonographic Image Processing

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Do all antihypertensive drugs improve carotid intima‐media thickness? A network meta‐analysis of randomized controlled trials