Effects of l-Triiodothyronine and the Thyromimetic L-94901 on Serum Lipoprotein Levels and Hepatic Low-Density Lipoprotein Receptor, 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase, and Apo A-I Gene Expression

Ness, Gene C.; Lopez, Dayami; Chambers, Christopher M.; Newsome, William; Cornelius, Peter; Long, Catherine; Harwood, H. James

doi:10.1016/s0006-2952(98)00119-1

Cited by 92 publications

(60 citation statements)

References 30 publications

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“…Thyroid hormones accelerate the expression of LDL receptors on the hepatocytes [9] and increase the activity of lipid-lowering liver enzymes, resulting in a reduction in lowdensity lipoprotein levels [10]. This is well correlated with the results of our study showing that the patients in the rh-TSH group, who were in euthyroid state, showed lower total cholesterol and LDL cholesterol levels than the THW group.…”

Section: Discussionsupporting

confidence: 88%

Comparison of the Influence on the Liver Function Between Thyroid Hormone Withdrawal and rh-TSH Before High-Dose Radioiodine Therapy in Patients with Well-Differentiated Thyroid Cancer

Han

Lim

Yun

et al. 2012

Nucl Med Mol Imaging

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Purpose An elevated thyroid stimulating hormone level (TSH) is essential to stimulate the uptake of radioiodine into thyroid remnants and metastases of thyroid cancer when a patient undergoes high-dose radioiodine therapy. Nowadays, recombinant human thyroid stimulating hormone (rh-TSH) is increasingly used instead of the classic method of thyroid hormone withdrawal (THW). However, beyond the therapeutic effects, clinical differences between the two methods have not yet been clearly demonstrated. The aim of this work was to investigate the effects of the two methods, especially on liver function. Methods We identified 143 evaluable patients who were further divided into two groups: THW and rh-TSH. We first reviewed the aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, which were measured during the admission period for total thyroidectomy. We called these liver enzyme levels "base AST" and "base ALT." We also assessed other chemistry profiles, including AST, ALT, total cholesterol, LDL cholesterol, alkaline phosphatase (ALP), total bilirubin (TB), and triglyceride (TG), which were measured on admission day for high-dose radioiodine therapy. We called these liver enzyme levels "follow-up AST" and "follow-up ALT." We compared the changes in base and follow-up liver enzyme levels and the other chemistry profiles between the two groups. Results The base AST and base ALT levels of the two groups were within normal range, and there was no significant difference between the two groups. In contrast to these base liver enzyme levels, follow-up liver enzyme levels between the two groups showed significant differences. Patients in the THW group had higher follow-up AST and ALT levels than did the rh-TSH group. Patients in the THW group also had higher levels of total cholesterol and LDL cholesterol than did the patients in the rh-TSH group. However there were no statistically significant differences in ALP, total bilirubin, and triglyceride levels between the two groups. Conclusions In this retrospective analysis of liver function, the use of rh-TSH for high-dose radioiodine therapy had less of an effect on liver function and cholesterol levels than dose thyroid hormone withdrawal. This suggests that rh-TSH can be used effectively and safely especially for patients with metabolic syndrome.

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Section: Discussionsupporting

confidence: 88%

Comparison of the Influence on the Liver Function Between Thyroid Hormone Withdrawal and rh-TSH Before High-Dose Radioiodine Therapy in Patients with Well-Differentiated Thyroid Cancer

Han

Lim

Yun

et al. 2012

Nucl Med Mol Imaging

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“…In rats, thyroid hormone treatment markedly increases LDLR mRNA and protein levels. [60][61][62] The increase in LDLR mRNA is not due to alterations in message stability, 63 but rather an increased rate of LDLR transcription. 64 Recent work has shed light on the mechanisms by which thyroid hormone activates LDLR transcription.…”

Section: Thyroid Hormonementioning

confidence: 99%

Overview of the LDL receptor: relevance to cholesterol metabolism and future approaches for the treatment of coronary heart disease

Lagor¹,

Millar²

2009

JRLCR

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“…RNA was dissolved in 50 L of Milli-Q water and the quantity of RNA was determined by measuring the absorbance at 260 nm, where purity was assessed by the A 260 / A 280 ratio ( 21 ). One-hundred and fifty micrograms total RNA was diluted in 150 L DEPCtreated water, and 150 L of a 20 m M Tris buffer, pH 7.5, containing 2 m M EDTA and 0.2% SDS, and 15 L of Oligotex-dT30 (Takara Bio Inc., Shiga, Japan).…”

Section: Rna Extraction From Liver and Rt-pcr Analysis Of Gene Expresmentioning

confidence: 99%

Retrograded Tapioca Starch Prevents Ovarian Hormone Deficiency-Induced Hypercholesterolemia

Liu

Sawauchi

Ogawa

et al. 2006

J Nutr Sci Vitaminol

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SummaryThe purpose of this study was to examine whether retrograded tapioca starch (RS3-tapioca) prevents ovarian hormone deficiency-induced hypercholesterolemia. Sixmonth-old Wistar female rats were subjected to sham-operation or ovariectomy, and fed a cholesterol-free purified diet with or without RS3-tapioca (150 g/kg diet) instead of digestible cornstarch for 28 d. Body weight gain and food intake increased in ovariectomized rats (OVX-rats). Plasma total cholesterol concentration was lowered by RS3-tapioca in OVX rats, but not in sham-operated rats. Liver lipids increased in OVX-rats, but liver cholesterol concentration was not affected by ovariectomy and RS3-tapioca. CYP7A1 activity, small intestinal and cecal bile acid content, and fecal bile acid excretion were increased by RS3-tapioca. The ratio of cholic acid groups to chenodeoxycholic acid groups in the bile acid of the small intestine was increased by RS3-tapioca. Thus, the preventive effect of RS3-tapioca on the ovarian hormone deficiency-associated increase in plasma cholesterol concentration appears to be mediated by accelerated fecal excretion of bile acid and an increase in the intestinal pool of bile acid. Key Words retrograded tapioca starch (RS3-tapioca), ovariectomized rats, plasma cholesterol Resistant starch (RS) is, by definition, the sum of starch and the products of starch degradation not absorbed in the small intestine of healthy individuals ( 1 ). RS is now organized into four categories: physically inaccessible starch (RS1), resistant granules and high amylose starches (RS2), retrograded starches (RS3) and chemically modified starches (RS4) ( 2 ). RS appears to have various physiological effects, such as a decrease in postprandial glycemic and insulinemic responses, reduction of plasma cholesterol and triglyceride concentrations, an improvement in whole body insulin sensitivity, an increase in satiety, and a reduction in fat storage ( 3 ).Menopause, whether natural or surgically induced, is associated with elevated concentrations of circulating total cholesterol and low-density lipoprotein-cholesterol, Placing postmenopausal women at greater risk of coronary heart disease (CHD) ( 4 -7 ). Estrogen replacement therapy (ERT) in postmenopausal women reduces the risk of CHD, in part, by modulating plasma cholesterol; however ERT and cholesterol-lowering pharmacological agents may have side effects.Starch consists of a mixture of two polymers, amylose and amylopectin. Different starches have different relative ratios of amylose and amylopectin. The properties of a starch are highly influenced by the structure of its components. The different properties depend on the crystalline ultra-structure, which differs according to the origin of the starch. X-ray diffraction has been used to characterize the crystalline/amorphous nature of starches. The X-ray diffraction pattern of tapioca starch is C type, while that of corn, potato and rice starch is A, B and A type, respectively. The physical and chemical properties of RS3-tapioca may differ from t...

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Effects of l-Triiodothyronine and the Thyromimetic L-94901 on Serum Lipoprotein Levels and Hepatic Low-Density Lipoprotein Receptor, 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase, and Apo A-I Gene Expression

Cited by 92 publications

References 30 publications

Comparison of the Influence on the Liver Function Between Thyroid Hormone Withdrawal and rh-TSH Before High-Dose Radioiodine Therapy in Patients with Well-Differentiated Thyroid Cancer

Comparison of the Influence on the Liver Function Between Thyroid Hormone Withdrawal and rh-TSH Before High-Dose Radioiodine Therapy in Patients with Well-Differentiated Thyroid Cancer

Overview of the LDL receptor: relevance to cholesterol metabolism and future approaches for the treatment of coronary heart disease

Retrograded Tapioca Starch Prevents Ovarian Hormone Deficiency-Induced Hypercholesterolemia

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