Effects of L-Citrulline Supplementation and Aerobic Training on Vascular Function in Individuals with Obesity across the Lifespan

Flores-Ramírez, Anaisa G; Tovar-Villegas, Verónica Ivette; Maharaj, Arun; Garay‐Sevilla, Ma. Eugenia; Figueroa, Arturo

doi:10.3390/nu13092991

Cited by 6 publications

(3 citation statements)

References 139 publications

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“… 77 Therefore, regular aerobic exercise alone may not improve vascular function in obese older adults, for whom a combination of other types of intervention may be necessary to achieve the goal of improved vascular function, including aerobic and resistance exercise, a proper diet, and nutritional supplements. 20 , 78 , 79 , 80 , 81 …”

Section: Discussionmentioning

confidence: 99%

Effects of regular aerobic exercise on vascular function in overweight or obese older adults: A systematic review and meta-analysis

Liu

Wan

et al. 2023

Journal of Exercise Science & Fitness

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Section: Discussionmentioning

confidence: 99%

Effects of regular aerobic exercise on vascular function in overweight or obese older adults: A systematic review and meta-analysis

Liu

Wan

et al. 2023

Journal of Exercise Science & Fitness

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“…They were told to consume 4 capsules in the morning before the first meal and 4 capsules at night after dinner every day of the week without exception. The dose of 6 g/day was adopted based on review of the existing literature [22,[26][27][28][29][30][31]. Follow-up and adherence were assessed every two weeks and were evaluated with the Morisky-Green test [32] and capsule count; using ≥80% of the supplements was regarded as compliance with the protocol.…”

Section: Methodsmentioning

confidence: 99%

Oral L-Citrulline Supplementation Improves Fatty Liver and Dyslipidemia in Adolescents with Abdominal Obesity: A Parallel, Double-Blind, Randomized Clinical Trial

Tovar-Villegas,

Kang,

Ibarra-Reynoso

et al. 2024

Gastroenterology Insights

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Obesity in adolescents is associated with non-communicable risk factors and diseases like metabolic-associated fatty liver disease (MAFLD), which is the liver manifestation of metabolic syndrome. L-citrulline is a non-protein amino acid that has shown positive effects on the degree of steatosis in animals with non-alcoholic fatty liver disease (NAFLD). The aim of the study was to evaluate the effect of oral L-citrulline supplementation on liver function and cardiovascular risk factors in adolescents with abdominal obesity and MAFLD. A prospective, double-blind clinical trial in adolescents with abdominal obesity was randomized into two groups: forty-two adolescents were supplemented with L-citrulline (6 g of L-citrulline/day) (n = 22) and placebo (n = 20) for eight weeks. The variables evaluated were anthropometry, blood pressure, glucose, insulin, HOMA-IR, L-citrulline, L-arginine, malondialdehyde, lipid profile, liver profile, urea, uric acid, and hepatic steatosis by ultrasound. After supplementation, the L-citrulline group had a decrease in liver fat accumulation (p = 0.0007); increases in body weight (p = 0.02), glucose (p = 0.03), and HOMA-IR (p = 0.03); and decreases in BMI (p = 0.002), total cholesterol (p = 0.001), HDL-C (p = 0.01), LDL-C (p = 0.002), and alkaline phosphatase (p = 0.05). L-citrulline for eight weeks decreases hepatic fat accumulation and LDL-C levels in adolescents with abdominal obesity and MAFLD.

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“…Other beneficial effects of citrulline supplementation include improved blood pressure, glucose and lipid profile, and the bioavailability of arginine and nitric oxide. 26 So far, no studies have assessed the use of citrulline levels as a predictor of long-term mortality in patients with CVD. Moreover, data are lacking on the association between levels of citrulline and the microbiota-derived metabolite trimethylamine N-oxide (TMAO).…”

Section: Introductionmentioning

confidence: 99%

Citrulline and long-term mortality in patients with cardiovascular disease

Konieczny¹,

Żurawska-Płaksej²,

Kaaz³

et al. 2022

Adv Clin Exp Med

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Background. Cardiovascular disease (CVD) is associated with intestinal barrier dysfunction and increased intestinal permeability. Increased intestinal permeability to gut microbial metabolites may accelerate the progression of CVD. Plasma citrulline levels are a marker of functional enterocyte mass, and reduced citrulline levels indicate intestinal epithelial damage. Citrulline was reported as a useful prognostic marker in critically ill patients. However, data are lacking on the association of citrulline with long-term mortality in patients with CVD and with the levels of trimethylamine N-oxide (TMAO), a microbiota-derived metabolite which has been implicated in the pathogenesis of CVD. Objectives.To assess the effect of citrulline levels, a marker of intestinal barrier disruption, on long-term mortality in patients with CVD. Moreover, the relationship between the concentrations of 2 biomarkers -citrulline and TMAO -was assessed.Materials and methods. Serum citrulline levels were retrospectively assessed in 1036 consecutive patients with CVD (median age: 62 years; 61% men) hospitalized between 2013 and 2015. Associations of citrulline levels with 5-year mortality rates as well as anthropometric and biochemical parameters were evaluated for the entire study group and in subgroups of patients with acute coronary syndrome (ACS), chronic coronary syndrome, chronic heart failure (chronic HF), and atrial fibrillation (AF). Correlations between serum citrulline and TMAO levels were assessed. Results. The median citrulline level in the study population was 22.5 µM (interquartile range (IQR): 17.8-27.9). Citrulline levels were not associated with 5-year mortality in patients with CVD (hazard ratio (HR) = 0.99; 95% confidence interval (95% CI): 0.97-1.00; p = 0.49). Median citrulline levels differed significantly between deceased patients and survivors at 5 years in patients with ACS (p = 0.025). There were no significant correlations between citrulline and TMAO levels (Kendall's tau = 0.027).Conclusions. Decreasing citrulline levels do not predict long-term mortality of hospitalized patients with CVD. Moreover, they are not associated with the serum levels of TMAO in these patients.

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Effects of L-Citrulline Supplementation and Aerobic Training on Vascular Function in Individuals with Obesity across the Lifespan

Cited by 6 publications

References 139 publications

Effects of regular aerobic exercise on vascular function in overweight or obese older adults: A systematic review and meta-analysis

Effects of regular aerobic exercise on vascular function in overweight or obese older adults: A systematic review and meta-analysis

Oral L-Citrulline Supplementation Improves Fatty Liver and Dyslipidemia in Adolescents with Abdominal Obesity: A Parallel, Double-Blind, Randomized Clinical Trial

Citrulline and long-term mortality in patients with cardiovascular disease

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