Effects of L-Carnitine on Oxidant/Antioxidant Status in Acetic Acid-Induced Colitis

Çetinkaya, Ali; Bülbüloğlu, Ertan; Kantarçeken, Bülent; Çıralık, Harun; Kurutaş, Ergül Belge; Büyükbeşe, Mehmet Akif; Gümüşalan, Yakup

doi:10.1007/s10620-006-3160-9

Cited by 101 publications

(88 citation statements)

References 40 publications

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“…The wound-healing effect of H. perforatum extract seems to be mainly due to increased stimulation of fibroblast collagen production and activation of fibroblast cells in polygonal shape, which play a role in wound repair by closing the damaged area (30). In addition, there are several reports in which the MDA levels increased in UC, but decreased with treatment by chemical agents (31)(32)(33) or medicinal plant extracts (8,13,14). MDA is frequently used in measurement of lipid peroxide levels and, exhibiting good correlation with degree of lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

The Healing Effect of Hypericum perforatum Extract on Acetic Acid-Induced Ulcerative Colitis in Rat

Tanideh¹,

Nematollahi²,

Hosseini³

et al. 2014

Ann Colorectal Res

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Background: Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD). There are several chemical and herbal drug regimens for treatment of UC. Objectives: The aims of this study were to investigate the effects of Hypericum perforatum on histopathological and tissue malondialdehyde (MDA) level of colonic tissue in rat with induced UC. Materials and Methods: Two milliliters of 3% acetic acid was administered into the colon to induce UC. Seventy rats were divided into seven equal groups. Groups I and II received 1 mL of 600 and 300 mg/kg H. perforatum extract orally per day respectively; groups III and IV received 1 mL of 20% and 10% intra-colonic gel form of H. perforatum extract daily respectively; group V as positive control received 2 mL of intra-colonic asacol; group VI was a negative control receiving 0.5 mL/kg of normal saline after induction of UC; group VII received just intra-colonic gel base. All the animals were evaluated for histological changes and tissue MDA level seven days after the treatment. Results: H. perforatum extract in the two forms of trans-rectal and oral administration on the seventh day after the therapy could result in a more healing effect on acetic acid-induced damaged colonic tissue with a reduction in the MDA activity. In trans-rectal administration, the 20% gel form had a better healing response than the 10% gel form and was prominently more effect on the seventh day of the therapy. In oral administration of strawberry extract, the 600 mg/kg dosage had a better healing response than the 300 mg/kg and was significantly more effective on the seventh day of therapy. Conclusions: So H. perforatum may be considered as a treatment of choice for UC especially in gel form to broaden the current therapy options of the disease.

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Section: Discussionmentioning

confidence: 99%

The Healing Effect of Hypericum perforatum Extract on Acetic Acid-Induced Ulcerative Colitis in Rat

Tanideh¹,

Nematollahi²,

Hosseini³

et al. 2014

Ann Colorectal Res

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“…Previous studies have indicated that L-carnitine has an important role in oxidative/antioxidative balance as well as in the transport function of long-chain fatty acids into the mitochondria in biological systems [12][13][14][15]. However, the effects of L-carnitine on specific antioxidant enzymes, such as GPX, CAT and MPO, which detoxify H 2 O 2 in water, have been reported independently in a few studies [14,25]. There are no studies about the dose-dependent protective effect of L-carnitine against the free radical damage induced by hyperthyroidism in rat liver tissue.…”

Section: Discussionmentioning

confidence: 99%

“…This finding was most likely caused by a decrease in the damage produced by free oxygen radicals [14]. Cetinkaya et al [25] investigated the effects of L-carnitine at a dose of 500 mg/kg (i.p.) on the oxidant/antioxidant status in acetic acid-induced colitis and reported that L-carnitine administration to the acetic acid-treated rats significantly reduced the MDA level and MPO activity, whereas the CAT activity increased in colon tissue.…”

Section: Discussionmentioning

confidence: 99%

Dose-Dependent Protective Effect of L-Carnitine on Oxidative Stress in the Livers of Hyperthyroid Rats

Yıldırım

Dane

et al. 2013

EAJM

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Objective: The present study was designed to investigate the dosedependent protective effect of L-carnitine (LC) on thyroid hormoneinduced oxidative stress in rat liver tissue. Materials and Methods:Twenty-one male Sprague Dawley rats were divided into four groups: control, hyperthyroidism, hyperthyroidism plus L-carnitine 100, and hyperthyroidism plus L-carnitine 500. Hyperthyroidism was induced in rats by injecting 250 μg of L-thyroxine/ kg body weight/day for twenty consecutive days. The activities of catalase (CAT), glutathione peroxidase (GPX) and myeloperoxidase (MPO) and the level of malondialdehyde (MDA) were measured in liver homogenates. Results:The liver CAT, GPX and MPO activities were significantly lower in the hyperthyroid rats than in the control group. Treating hyperthyroid rats with both low-dose (100 mg/kg) and high-dose (500 mg/kg) L-carnitine for 10 days resulted in a marked increase in the activities of the antioxidant enzymes in the liver tissue. Conclusion:The present study indicates that the low-dose L-carnitine application was sufficient to prevent L-thyroxine-induced oxidative stress in rat livers.Key Words: Catalase, glutathione peroxidase, L-carnitine, Liver, Malondialdehyde, Myeloperoxidase Özet Amaç: Bu çalışma rat karaciğer dokusunda tiroid hormonu ile uyarı-lan oksidatif stres üzerine L-karnitinin doza bağlı koruyucu etkilerini araştırmaktı. Gereç ve Yöntem:Yirmi bir erkek Sprague Dawley rat 4 gruba bö-lündü: Kontrol, hipertroidi, hipertiroidi + L-karnitine 100 ve hipertiroidi + L-karnitine 500. Hipertiroidi, yirmi gün boyunca ratlara 250 μg / kg dozunda L-Thyroxine enjeksiyonu uygulanarak oluşturuldu. Karaciğer homojenatlarında katalaz (CAT), glutatyon peroksidaz (GPX), myeloperoksidaz (MPO) aktiviteleri ve malondialdehit (MDA) düzeyleri ölçüldü. Bulgular:Kontrollerle karşılaştırıldığında hipertiroidili ratlarda karaciğer CAT, GPX ve MPO aktiviteleri belirgin olarak azaldı. 10 gün boyunca hem düşük doz (100 mg/kg) hem de yüksek doz (500 mg/ kg) L-karnitin uygulaması hipertiroidili ratlarda karaciğer antioksidan enzim aktivitelerinde belirgin bir artışa yol açtı.Sonuç: Bu çalışmanın sonuçları L-Tiroksin ile uyarılan rat karaciğerin-deki oksidatif stresi önlemek için düşük doz L-karnitin uygulamasının yeterli olduğunu göstermektedir.

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“…The effects of LC on the metabolism of tissues in organs such as the heart [15], brain [16], and liver [13] have been studied widely. Current reports suggest that LC may play a significant role in balancing antioxidative systems and has an antiperoxidative effect on some tissues [17,18]. The aim of this study was to investigate possible protective effects of exogenous LC supplementation on CDDP-induced oxidative organ injuries, and its effects on the levels of antioxidant enzymes and lipid peroxidation, as well as histological changes.…”

Section: Introductionmentioning

confidence: 98%

Protective effect of L-carnitine against cisplatin-induced liver and kidney oxidant injury in rats

et al. 2009

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AbstractThe present study was designed to investigate the protective effects of L-carnitine (LC) on changes in the levels of lipid peroxidation and endogenous antioxidants induced by cisplatin (cis-diamminedichloroplatinum II, CDDP) in the liver and kidney tissues of rats. Twenty-four Sprague Dawley rats were equally divided into four groups of six rats each: control, cisplatin, L-carnitine, and L-carnitine plus cisplatin. The degree of protection produced by L-carnitine was evaluated by determining the level of malondialdehyde (MDA). The activity of glutathione (GSH), glutathione peroxidase (GSH-Px), glutathione S-transferase (GST), and superoxide dismutase (SOD) were estimated from liver and kidney homogenates, and the liver and kidney were histologically examined as well. L-carnitine elicited significant liver and kidney protective activity by decreasing the level of lipid peroxidation (MDA) and elevating the activity of GSH, GSHPx, GST, and SOD. Furthermore, these biochemical observations were supported by histological findings. In conclusion, the present study indicates a significant role for reactive oxygen species (ROS) and their relation to liver and kidney dysfunction, and points to the therapeutic potential of LC in CDDP-induced liver and kidney toxicity.

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Effects of L-Carnitine on Oxidant/Antioxidant Status in Acetic Acid-Induced Colitis

Cited by 101 publications

References 40 publications

The Healing Effect of Hypericum perforatum Extract on Acetic Acid-Induced Ulcerative Colitis in Rat

The Healing Effect of Hypericum perforatum Extract on Acetic Acid-Induced Ulcerative Colitis in Rat

Dose-Dependent Protective Effect of L-Carnitine on Oxidative Stress in the Livers of Hyperthyroid Rats

Protective effect of L-carnitine against cisplatin-induced liver and kidney oxidant injury in rats

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