Effects of L‐arginine and L‐carnitine in hypoxia/reoxygenation‐induced intestinal injury

Abstract

Oxidative stress contributes to the pathogenesis of H/R-induced intestinal injury. The glutathione redox cycle may have a crucial role in the H/R-induced intestinal injury. L-arginine and L-carnitine supplementations ameliorate the histological evidence of H/R-induced intestinal injury and decrease lipid peroxidation but do not alter the glutathione-related antioxidant enzyme activities.

Protective effects of clarithromycin in rats with hypoxia/reoxygenation-induced intestinal injury

“…Although the etiology of NEC remains uncertain, hypoxia and ischemia appear to play an important role in the pathogenesis of this ischemic bowel disease [3][4][5][6][7][8].…”

“…This protocol was not performed on the control group. At the sixth hour after H/R, all rat pups in all groups were killed on the fourth day of life [7]. Histopathologic injury score (HIS) and MDA, NO, GSH (total thiol), and GSH-Px activities were measured on intestinal tissue samples.…”

“…Hypoxia and ischemia appear to play an important role in the disruption of mucosal integrity and, following reperfusion, have a major influence in ischemia-related injury. The metabolites of oxidative stress, produced during reperfusion, may play a critical role in the pathophysiology of NEC [3][4][5][6][7][8].…”

“…Glutathione (GSH) metabolism is one of the most essential antioxidative defense systems, and glutathione peroxidase (GSH-Px) is a dominant enzyme dealing with toxic metabolites of oxidative stress [7,[10][11][12].…”

Suppression of inflammatory cytokine production and oxidative stress by CO-releasing moleculesliberated CO in the small intestine of thermally-injured mice1

“…Tissue MDA content, the last product of lipid breakdown caused by oxidative stress, is considered to be a good indicator of radical-induced lipid peroxidation [44] . In this study, we found increased intestinal MDA levels in the burnt mice groups, suggesting that in our experimental conditions, after 24 h from manipulation, a significant increase of oxidative stress occurs.…”