Effects of KW-5092, a Novel Gastroprokinetic Agent, on the Delayed Colonic Propulsion in Rats.

Takasaki, Kotaro; Kishibayashi, Nobuyuki; Ishii, Akio; Karasawa, Akira

doi:10.1254/jjp.65.67

Cited by 23 publications

(20 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, the laxative effects of FRe were evaluated based on changes in fecal parameters (numbers, weight and water content), the gastrointestinal transit ratio (motility), fecal mucus content, number of colonic mucus-producing cells and the mean colonic mucosa thickness in rats with loperamide-induced constipation, used as a model of spastic constipation (11). The laxative effects of FRe were compared with those of S. picosulfate, a cathartic stimulant that requires activation by colonic bacteria (19,20), as a reference drug (21).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Laxative effects of fermented rice extract in rats with loperamide-induced constipation

Choi

Kim²,

Cho³

et al. 2014

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Constipation is a common problem in males and females. The aim of the present study was to evaluate the laxative effects of fermented rice extract (FRe) on rats with loperamide-induced constipation. FRe (100, 200 and 300 mg/kg) was administered orally once per day for six days following 1 h loperamide treatment. The laxative effects of FRe were compared with those of sodium picosulfate (S. picosulfate). Following the induction of constipation in the rats, a marked decrease was observed in the fecal pellet number and water content discharged over 24 h, the surface mucus thickness in the colonic lumen, intestinal charcoal transit ratio, thickness of the colonic mucosa and the number of mucus-producing cells, while an increase was observed in the number of fecal pellets remaining in the colonic lumen and their mean diameter, as compared with the normal vehicle control rats. These conditions were significantly alleviated following the administration of the three doses of FRe when compared with the loperamide control group. However, the alleviating effects were lower than those of S. picosulfate, with the exception of the intestinal charcoal transit ratio. Similar effects on the intestinal charcoal transit ratio were detected for the three doses of FRe when compared with the S. picosulfate-treated rats. In conclusion, the results indicated that FRe exhibits a laxative effect without causing diarrhea, as compared with sodium picosulfate; thus, FRe may be effective as a complementary medicine in patients suffering from lifestyle-induced constipation.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The drug inhibits intestinal water secretion (8) and colonic peristalsis (9), which extends the fecal evacuation time and delays intestinal luminal transit (10). Thus, loperamide-induced constipation is considered to be a model of spastic constipation (11). …”

Section: Introductionmentioning

confidence: 99%

Laxative effects of fermented rice extract in rats with loperamide-induced constipation

Choi

Kim²,

Cho³

et al. 2014

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

show abstract

“…The colonic propulsive activity was measured according to the method of Takasaki et al 9) with a minor modiˆcation. On day 22, each rat was subcutaneously treated with either saline or a single dose of morphine, and a Te‰on bead (3.2 mm in diameter) was then inserted into the distal colon 3 cm above the anus 30 min after the injection.…”

Section: Methodsmentioning

confidence: 99%

Effect of Dietary Fiber on Morphine-induced Constipation in Rats

Niwa¹,

Nakao²,

Hoshi³

et al. 2002

Bioscience, Biotechnology, and Biochemistry

View full text Add to dashboard Cite

Morphine is used to alleviate chronic cancer pain. However, constipation is a major adverse effect that often detracts from the patient's quality of life. In this study, we investigated the effectiveness of dietary fiber on morphine-induced constipation. Rats were fed on a normal diet or one containing either 10% or 20% apple fiber for two weeks before morphine was administered. In the control diet group, the fecal number and dry weight were decreased by treating with morphine in a dose-dependent manner. Moreover, the motility of the small and large intestines was reduced. The fecal number and weight were increased and the colon motility was promoted by dietary fiber, regardless of whether morphine was being administered. The dietary fiber increased the concentration of short-chain fatty acids (SCFAs) in the cecum. These results suggest that dietary fiber has a preventative effect on morphine-induced constipation by increasing SCFAs in the cecum, and thereby promoting colon motility in rats.

show abstract

“…This inhibition extends faecal evacuation time and delays intestinal luminal transit. Loperamideinduced constipation is therefore considered to be a model of spastic constipation [15].…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Effect of <i>Lecaniodiscus cupanioides</i> (Sapindaceae) Aqueous Root Extract in Loperamide- Induced Constipated Rats

Nafiu¹,

Abdulsalam²,

Jimoh³

et al. 2015

Trop. J. Pharm Res

View full text Add to dashboard Cite

Effects of KW-5092, a Novel Gastroprokinetic Agent, on the Delayed Colonic Propulsion in Rats.

Cited by 23 publications

References 5 publications

Laxative effects of fermented rice extract in rats with loperamide-induced constipation

Laxative effects of fermented rice extract in rats with loperamide-induced constipation

Effect of Dietary Fiber on Morphine-induced Constipation in Rats

Ameliorative Effect of <i>Lecaniodiscus cupanioides</i> (Sapindaceae) Aqueous Root Extract in Loperamide- Induced Constipated Rats

Contact Info

Product

Resources

About