“…124) In contrast, the BK channel has consistently been an attractive drug target for the treatment of diseases due to smooth muscle hypercontractility, including hypertension, overactive bladder, incontinence, asthma, chronic obstructive pulmonary disease, and threatened premature labor. [138][139][140] Similar to ATP-sensitive K + channel openers, such as nicorandil, 141) minoxidil, 142) (levo) cromakalim 143,144) KRN2391, 145) and KRN4884, 146) the development of BK channel openers targeting these diseases has been extensively challenged, but not yet successful in clinical trials. 138,147) The main undesired effects of BK channel openers are facial flushing, migraine, and postural hypotension.…”