Effects of kolaviron on hepatic oxidative stress in streptozotocin induced diabetes

Oyenihi, Omolola R.; Brooks, Nicole L; Oguntibeju, Oluwafemi Omoniyi

doi:10.1186/s12906-015-0760-y

Cited by 39 publications

(34 citation statements)

References 28 publications

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“…Therefore, consumption of its stores by CCl 4 -induced scavenging free radicals is indicative of liver injury [57]. Glutathione peroxidase (GPX) plays a pivotal role in protective defense system in the liver [58]. Diminished activity of GPX, due to ROS, is also another manifestation of propagated liver injury.…”

Section: -Induced Hepatotoxicitymentioning

confidence: 99%

Quercetin Loaded Monolaurate Sugar Esters-Based Niosomes: Sustained Release and Mutual Antioxidant—Hepatoprotective Interplay

et al. 2020

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Flavonoids possess different interesting biological properties, including antibacterial, antiviral, anti-inflammatory and antioxidant activities. However, unfortunately, these molecules present different bottlenecks, such as low aqueous solubility, photo and oxidative degradability, high first-pass effect, poor intestinal absorption and, hence, low systemic bioavailability. A variety of delivery systems have been developed to circumvent these drawbacks, and among them, in this work niosomes have been selected to encapsulate the hepatoprotective natural flavonoid quercetin. The aim of this study was to prepare nanosized quercetin-loaded niosomes, formulated with different monolaurate sugar esters (i.e., sorbitan C12; glucose C12; trehalose C12; sucrose C12) that act as non-ionic surfactants and with cholesterol as stabilizer (1:1 and 2:1 ratio). Niosomes were characterized under the physicochemical, thermal and morphological points of view. Moreover, after the analyses of the in vitro biocompatibility and the drug-release profile, the hepatoprotective activity of the selected niosomes was evaluated in vivo, using the carbon tetrachloride (CCl 4 )-induced hepatotoxicity in rats. Furthermore, the levels of glutathione and glutathione peroxidase (GSH and GPX) were measured. Based on results, the best formulation selected was glucose laurate/cholesterol at molar ratio of 1:1, presenting spherical shape and a particle size (PS) of 161 ± 4.6 nm, with a drug encapsulation efficiency (EE%) as high as 83.6 ± 3.7% and sustained quercetin release. These niosomes showed higher hepatoprotective effect compared to free quercetin in vivo, measuring serum biomarker enzymes (i.e., alanine and aspartate transaminases (ALT and AST)) and serum biochemical parameters (i.e., alkaline phosphatase (ALP) and total proteins), while following the histopathological investigation. This study confirms the ability of quercetin loaded niosomes to reverse CCl 4 intoxication and to carry out an antioxidant effect.Pharmaceutics 2020, 12, 143 2 of 18 and anticancer activities [1][2][3]. These intrinsic properties, together with their biocompatibility and remarkable antioxidant activity, have attracted researchers' attention to explore potential therapeutic applications [4,5].Quercetin (3, 30, 4, 5, 7-pentahydroxyflavone) is probably the most studied bioflavonoid, belonging to the family of flavonols; its therapeutic applications include hepatoprotection [6], prevention of neural cell apoptosis [7] and cancer chemo-prevention and treatment [8].Quercetin acts as strong antioxidant by scavenging free radicals and transition metal ions, thus decreasing the process of lipid peroxidation, which is responsible for the development of many diseases, e.g., cardiovascular and neurodegenerative diseases, as well as liver damage [9][10][11].However, quercetin therapeutic applications present challenges due to (i) low aqueous solubility, (ii) photo and oxidative degradability, (iii) high first-pass effect, (iv) poor intestinal absorption and, hence, low systemic...

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Section: -Induced Hepatotoxicitymentioning

confidence: 99%

Quercetin Loaded Monolaurate Sugar Esters-Based Niosomes: Sustained Release and Mutual Antioxidant—Hepatoprotective Interplay

et al. 2020

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“…In addition, the ORAC index (oxygen radical absorbance capacity), the reduced glutathione (GSH) level, the reduced oxidized glutathione ratio (GSH: GSSG) and catalase (CAT) activity were decreased in the diabetic rat liver. The TUNEL assay showed an increase in apoptotic cell death in the livers of these animals 21 . In using TBARS as a measure of lipid peroxidation in lung tissue, a significant increase was seen in the diabetic animals in comparison with the experimental group and control group (healthy animals).…”

Section: ■ Discussionmentioning

confidence: 85%

Pulmonary oxidative stress in diabetic rats exposed to hyperoxia

Paiva

Silva²,

Souza³

et al. 2017

Acta Cir. Bras.

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Pulmonary oxidative stress in diabetic rats exposed to hyperoxia 1 1-Experimental SurgeryActa Cir Bras. 2017;32(7):503-514 AbstractPurpose: To evaluate the pulmonary oxidative stress in diabetic rats exposed to hyperoxia for 90 minutes. Methods: Forty male Wistar rats were divided into four groups, each one containing 10 animals, according to the oxygen concentration to which they were exposed: 21%, 50%, 75% and 100% (hyperoxia). In each group five animals were randomly induced to diabetes by means of at a dose of 55 mg/kg of streptozotocin (STZ). Results: Seventy two hours after diabetes induction, a significant difference was seen in blood glucose in the experimental groups in comparison with the control. In the experimental groups a significant difference was observed in the concentration of malondialdehyde (MDA) in lung tissue and blood plasma (p<0.05), except the 50% group. In the control group, significant differences in the MDA concentration in plasma and lung tissue were also observed (p<0.05), except the 75% group. The MDA concentration in lung tissue in comparison with the diabetic and non-diabetic groups showed a significant difference in the 21% group; however, no difference was seen in the 75 and 100% groups. Conclusion:In diabetic animals high oxygen concentrations (75 and 100%) do not appear to exert deleterious effects on lipid peroxidation in lung tissue.

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“…To this end, Iqbal et al assessed the anthelmintic activity of N. tabacum leaves using live Haemonchus contortus (in vitro study) and in vivo testing by applying sheep naturally infected with mixed infection of gastrointestinal nematodes [37]. Fresh leaf of N. tabacum was obtained from the local market, identified by a botanist and crude extract of the leaves prepared according to previously described method using methanol and water [38]. In vitro study, the effectiveness of water and methanol extract of the plant is observed in the mortality of the worms when compared to a levamisole -a standard anthelmintic drug.…”

Section: Anthelmintic Activity Of N Tabacummentioning

confidence: 99%

Antidiabetic and Biological Activities of Nicotiana Tabacum: Possible Mechanisms

Oguntibeju

2020

Asian J Pharm Clin Res

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Diabetes mellitus is a growing global health problem. Reports predicted that diabetes mellitus could reach a pandemic level affecting people in both developing and developed countries. According to the World Health Organization, high blood glucose is seen as the third highest risk factor for premature mortality in diabetics. For several thousands of years before the adventure of orthodox medications, human beings have been using medicinal plants in the treatment of various disease conditions such as cancer, cardiovascular disease, infertility, bacterial, viral infections, and diabetes mellitus. The beneficial effects of selected medicinal therapies in the treatment and management of diabetes and diabetic complications have been reported. Many medicinal plants across Africa and Asia are known for their rich phytochemicals with effective components that have been observed to effectively reduce high blood glucose either in diabetic persons or diabetes-induced animals. The motivation for the use of medicinal plants includes availability, affordability, knowledge, effectiveness, and safety and some are of the opinion that medicinal plants and their derivatives could be effective and safe alternative treatment for diabetes and diabetic complications. Nicotiana tabacum is one of those plants with antidiabetic and pharmacological potentials which could benefit humans and animals if appropriately utilized; however, less attention has been focused on its antidiabetic properties. In fact, there is a paucity of information on the antidiabetic activities of N. tabacum. Therefore, this paper examines the antidiabetic and other biological activities of N. tabacum.

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Effects of kolaviron on hepatic oxidative stress in streptozotocin induced diabetes

Cited by 39 publications

References 28 publications

Quercetin Loaded Monolaurate Sugar Esters-Based Niosomes: Sustained Release and Mutual Antioxidant—Hepatoprotective Interplay

Quercetin Loaded Monolaurate Sugar Esters-Based Niosomes: Sustained Release and Mutual Antioxidant—Hepatoprotective Interplay

Pulmonary oxidative stress in diabetic rats exposed to hyperoxia

Antidiabetic and Biological Activities of Nicotiana Tabacum: Possible Mechanisms

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