2018
DOI: 10.3390/molecules23123071
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Effects of Kisspeptin-10 on Hypothalamic Neuropeptides and Neurotransmitters Involved in Appetite Control

Abstract: Besides its role as key regulator in gonadotropin releasing hormone secretion, reproductive function, and puberty onset, kisspeptin has been proposed to act as a bridge between energy homeostasis and reproduction. In the present study, to characterize the role of hypothalamic kisspeptin as metabolic regulator, we evaluated the effects of kisspeptin-10 on neuropeptide Y (NPY) and brain-derived neurotrophic factor (BDNF) gene expression and the extracellular dopamine (DA), norepinephrine (NE), serotonin (5-hydro… Show more

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Cited by 38 publications
(42 citation statements)
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“…The effects of the extracts (100-500 µg/mL) on myocyte C2C12 and prostate cancer PC3 cell viability were determined through the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test. The experimental conditions were fully described in our previous paper [35].…”
Section: Cell Cultures and Viability Testmentioning
confidence: 99%
“…The effects of the extracts (100-500 µg/mL) on myocyte C2C12 and prostate cancer PC3 cell viability were determined through the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test. The experimental conditions were fully described in our previous paper [35].…”
Section: Cell Cultures and Viability Testmentioning
confidence: 99%
“…Tissue and extracellular DA, 5-HT and NE levels were analyzed through an HPLC apparatus consisting of a Jasco (Tokyo, Japan) PU-2080 chromatographic pump and an ESA (Chelmsford, MA, USA) Coulochem III coulometric detector, equipped with a microdialysis cell (ESA-5014b) porous graphite working electrode and a solid state palladium reference electrode. The analytical conditions for biogenic amine identification and quantification were selected according to a previous study [20]. Briefly, the analytical cell was set at −0.150 V for detector 1 and at +0.300 V for detector 2, with a range of 100 nA.…”
Section: High Performance Liquid Chromatography (Hplc) Determination mentioning
confidence: 99%
“…116,117 In agreement with the kisspeptin effects on TIDA neurons, kisspeptin-10 has been recently shown to reduce dopamine release from the rat hypothalamic cell line Hypo-E22. 118 Nevertheless, these findings are in contrast to those of Navarro et al, 119 who also investigated the effect of ICV kisspeptin-10 on prolactin secretion in rats. In that study, kisspeptin-10 decreased prolactin levels in prepuberal male and female rats but had no effect in adult males.…”
Section: Kndy Inputs To Tida Neurons Are Major Regulators Of Prolactimentioning
confidence: 72%