Effects of Ketoconazole on the Clinical Recovery in Central Serous Chorioretinopathy

Chantarasorn, Yodpong; Rasmidatta, Kochapong; Pokawattana, Itsara; Silpa-archa, Sukhum

doi:10.2147/opth.s368427

Cited by 4 publications

(3 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An Addisonian crisis following treatment with terbinafine was previously described, pointing toward an anti-steroid effect of terbinafine [10]. The effect of other antifungal medications such as ketoconazole on CSCR has been previously explored as well; however, data have been inconsistent [11‒13]. Meyerle et al [13] reported on 5 patients with CSCR treated for 4 weeks with ketoconazole 600 mg/day.…”

Section: Discussionmentioning

confidence: 99%

“…After 4 weeks of treatment, the treatment and control groups demonstrated no significant change in BCVA or pigment epithelial detachment thickness. In a recent study by Chantarasorn et al [12], the efficacy of ketoconazole 400 or 600 mg per day was evaluated in 21 patients and compared to 20 patients who served as controls. Ketoconazole shortened the time to resolution (7 vs. 16 weeks; p < 0.01) and reduced the need for rescue laser treatment (23.8% vs. 50%; p = 0.01).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Central Serous Chorioretinopathy Development following Cessation of Terbinafine Treatment

Shmueli¹,

Nitzan²,

Averbukh³

2022

Case Rep Ophthalmol

View full text Add to dashboard Cite

This report describes a case of central serous chorioretinopathy (CSCR) occurring following cessation of terbinafine treatment. A 51-year-old man presented for a routine ophthalmic examination. He was treated with oral terbinafine for onychomycosis up to 3 months before the presentation. Spectral-domain optical coherence tomography (OCT) showed extrafoveal subretinal fluid in both eyes with small underlying pigment epithelial detachments. There were no additional relevant findings in the patient history or ocular examination. A diagnosis of CSCR was made. After 10 weeks without treatment, OCT demonstrated almost complete resolution of subretinal fluid in both eyes. The exact key ingredients of the perfect storm leading to CSCR in young, healthy individuals are still unknown. Here, we describe, to our knowledge, the first documented case, where the appearance of CSCR was apparently triggered by cessation of antifungal treatment. This unusual case may provoke further research that will bring us closer to understanding the mechanism behind the appearance of CSCR. It may also widen the scope of the routine anamnesis when dealing with patients newly diagnosed with this enigmatic condition.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Central Serous Chorioretinopathy Development following Cessation of Terbinafine Treatment

Shmueli¹,

Nitzan²,

Averbukh³

2022

Case Rep Ophthalmol

View full text Add to dashboard Cite

show abstract

“…Ketoconazole is another drug that effectively inhibits cortisol. Only one study has demonstrated a significant therapeutic effect of faster SRF resolution, 68 while the remaining studies demonstrated limited to no anatomic or BCVA benefit 69 compared with controls 70 ; evidence for the use of ketoconazole in CSCR therefore remains limited. Mifepristone is a drug with antiglucocorticoid activity that was studied in a small cohort of 16 patients and showed improvement in visual and anatomic metrics in approximately half of the patients 71 .…”

Section: Systemic Topical and Behavioral Therapiesmentioning

confidence: 99%