Effects of ketamine and propofol on muscarinic plateau potentials in rat neocortical pyramidal cells
Anne S. Fleiner,
Daniel Kolnier,
Nicholas Hagger-Vaughan
et al.
Abstract:Propofol and ketamine are widely used general anaesthetics, but have different effects on consciousness: propofol gives a deeply unconscious state, with little or no dream reports, whereas vivid dreams are often reported after ketamine anaesthesia. Ketamine is an N-methyl-D-aspartate (NMDA) receptor antagonist, while propofol is a gamma-aminobutyric-acid (GABAA) agonist, but these mechanisms do not fully explain how these drugs alter consciousness. Most previous in vitro studies of cellular mechanisms of anaes… Show more
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