Effects of Kaixin Powder (开心散) on melatonin receptor expression and 125I-Mel binding affinity in a rat model of depression

Huang, Yanli; Liang, Xiaolong; Qian, Li-qi; Cai, Chuan; Guo, Jun; Gao, Chao; Guan, Jianhua; Zhao, Guoping

doi:10.1007/s11655-014-1787-x

Cited by 13 publications

(10 citation statements)

References 21 publications

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“…Melatonin synthesis and secretion from the pineal gland are regulated by norepinephrine, implying a relationship been melatonin and depression as well (Huang et al . ). Melatonin secretion decreases during the onset of depression, and increases after remission.…”

Section: Introductionmentioning

confidence: 97%

Expression of Concern: The effects of melatonin supplementation on mental health, metabolic and genetic profiles in patients under methadone maintenance treatment

et al. 2018

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This investigation was designed to determine the effect of melatonin supplementation on mental health parameters, metabolic and genetic profiles in patients under methadone maintenance treatment (MMT). This randomized, double-blind, placebo-controlled, clinical trial was conducted among 54 patients under MMT. Participants were randomly allocated to receive either 10 mg melatonin (2 melatonin capsules, 5 mg each) (n = 26) or placebo (n = 28) once a day, 1 hour before bedtime for 12 weeks. Melatonin supplementation significantly decreased Pittsburgh Sleep Quality Index (β -4.08; 95 percent CI, -5.51, -2.65; P < 0.001), Beck Depression Inventory index (β -5.46; 95% CI, -8.92, -2.00; P = 0.003) and Beck Anxiety Inventory index (β -3.87; 95% CI, -5.96, -1.77; P = 0.001) and significantly increased International Index of Erectile Functions (β 5.59; 95% CI, 1.76, 9.42; P = 0.005) compared with the placebo. Subjects who received melatonin supplements had significantly lower serum insulin levels (β -2.53; 95% CI, -4.48, -0.59; P = 0.01), homeostasis model of assessment-insulin resistance (β -0.56; 95% CI, -1.03, -0.09; P = 0.01) and higher quantitative insulin sensitivity check index (β 0.01; 95% CI, 0.004, 0.02; P = 0.009) and HDL-cholesterol levels (β 3.71; 95% CI, 1.77, 5.64; P = 0.002) compared to placebo. Additionally, melatonin intake resulted in a significant reduction in serum high sensitivity C-reactive protein (β -0.15; 95% CI, -0.27, -0.02; P = 0.02), malondialdehyde (β -0.31; 95% CI, -0.57, -0.05; P = 0.02) and protein carbonyl (β -0.06; 95% CI, -0.09, -0.04; P < 0.001). This trial indicated that taking melatonin supplements for 12 weeks by patients under MMT had beneficial effects on their mental health metabolic profiles.

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Section: Introductionmentioning

confidence: 97%

Expression of Concern: The effects of melatonin supplementation on mental health, metabolic and genetic profiles in patients under methadone maintenance treatment

et al. 2018

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“… 62 It also regulates the activity of aralkylamine N -acetyltransferase (the penultimate and key enzyme in the hormone biosynthetic pathway) in the pineal body, melatonin biosynthesis, and the expression of the melatonin receptor Mel 1A in rat models of depression. 63 , 64 …”

Section: Resultsmentioning

confidence: 99%

Nine traditional Chinese herbal formulas for the treatment of depression: an ethnopharmacology, phytochemistry, and pharmacology review

Feng

Tang

Lin

et al. 2016

NDT

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Depression is a major mental disorder, and is currently recognized as the second-leading cause of disability worldwide. However, the therapeutic effect of antidepressants remains unsatisfactory. For centuries, Chinese herbal formulas (CHFs) have been widely used in the treatment of depression, achieving better therapeutic effects than placebo and having fewer side effects than conventional antidepressants. Here, we review the ethnopharmacology, phytochemistry, and pharmacology studies of nine common CHFs: “banxia houpo” decoction, “chaihu shugansan”, “ganmaidazao” decoction, “kaixinsan”, “shuganjieyu” capsules, “sinisan”, “wuling” capsules, “xiaoyaosan”, and “yueju”. Eight clinical trials and seven meta-analyses have supported the theory that CHFs are effective treatments for depression, decreasing Hamilton Depression Scale scores and showing few adverse effects. Evidence from 75 preclinical studies has also elucidated the multitarget and multipathway mechanisms underlying the antidepressant effect of the nine CHFs. Decoctions, capsules, and pills all showed antidepressant effects, ranked in descending order of efficacy. According to traditional Chinese medicine theory, these CHFs have flexible compatibility and mainly act by soothing the liver and relieving depression. This review highlights the effective treatment choices and candidate compounds for patients, practitioners, and researchers in the field of traditional Chinese medicine. In summary, the current evidence supports the efficacy of CHFs in the treatment of depression, but additional large-scale randomized controlled clinical trials and sophisticated pharmacology studies should be performed.

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“…Melatonin biosynthesis and secretion are mainly regulated by norepinephrine; the level of Melatonin reflects the norepinephrine activity in brain. And Melatonin secretion is an index of norepinephrine activity in depressed patients [24]. Several studies have supported this finding.…”

Section: Melatonin and Depressionmentioning

confidence: 87%

The Potential Role of Melatonin on Mental Disorders: Insights from Physiology and Pharmacology

Sun¹,

Wang²,

Jiang³

et al. 2016

Bipolar Disord

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Back Ground: Mental diseases have become common in modern society, which seriously harm the human health. The etiology of mental diseases is complex, general theories and methods of mechanism and prevention guidance of mental diseases cannot fully explain the clinical hysteresis effects of antipsychotic and antineuropathy drugs. Methods: In this review, we summarize recent advances in melatonin research, focusing on the mental diseases with special emphasis on the alterations of melatonin secretion and the associated changes in biological rhythms of disorders. Results: With the results from biochemical measurements in melatonin treatment of mental disorders, including anxiety, depression, schizophrenia, autism and attention deficit hyperactivity disorder, showed that melatonin treatment of mental disorders did not have serious negative consequences melatonin will likely be widely used in the treatment of mental disorders in clinical practice. At the same time, the measurements of the effects of melatonin treatments would become more standardized and effective. Conclusion: In the future, there would be a breakthrough progress in the treatment of mental disorders field by using melatonin. The potential role of melatonin on mental disorders would be attached great importance by related disciplines.

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Effects of Kaixin Powder (开心散) on melatonin receptor expression and 125I-Mel binding affinity in a rat model of depression

Abstract: KXP may have a similar effect as ramelteon. KXP improved depressive-like behavior by increasing the concentration of plasma MT and MT1 expression, thereby increasing three B(max) of MR to achieve the desired antidepressant effect.

Cited by 13 publications

References 21 publications

Expression of Concern: The effects of melatonin supplementation on mental health, metabolic and genetic profiles in patients under methadone maintenance treatment

Expression of Concern: The effects of melatonin supplementation on mental health, metabolic and genetic profiles in patients under methadone maintenance treatment

Nine traditional Chinese herbal formulas for the treatment of depression: an ethnopharmacology, phytochemistry, and pharmacology review

The Potential Role of Melatonin on Mental Disorders: Insights from Physiology and Pharmacology

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