Effects of Kaixin Powder on Expression of 5-HT Receptor in Hippocampus of Depressed Rats Induced by CUMS

Lu, Su-hong; Guo, Jun; Cai, Chuan; Liang, Xiaolong; Guan, Jianhua; Xia, Peng; Zhao, Guoping

doi:10.1016/s1674-6384(15)60031-4

Cited by 5 publications

(2 citation statements)

References 5 publications

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“…Depression, which is the most common type of affective disorders, is caused by a combination of biological, psychological, social, and other factors. Depressive syndrome is characterized by significant and lasting low mood (Lu et al, 2015 ). In clinical practice, drug classes used for the treatment of depression include monoamine oxidase inhibitors, selective serotonin noradrenaline reuptake inhibitors (SNRIs), selective serotonin reuptake inhibitors, and tricyclic antidepressants (Bouvier et al, 2003 ; Fava, 2003 ; Shen and Liang, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

Modulation of Neurogenesis through the Promotion of Energy Production Activity Is behind the Antidepressant-Like Effect of Colonial Green Alga, Botryococcus braunii

et al. 2017

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Algae have been recognized as important resources providing functional components due to their capacity to exert beneficial effects on health. Therefore, there is increasing interest in investigating the biological activity of algae. In this study, we evaluated the antidepressant-like effect of the administration of 100 mg/kg/day of the ethanol extract of colonial green alga Botryococcus braunii (EEB) for 14 consecutive days in the forced swimming test (FST)-induced depression in imprinting control region (ICR) mice. Imipramine, a commercial antidepressant drug, was used as a positive control. In addition, we investigated the molecular mechanisms underlying the effect of EEB by measuring ATP production and by assessing any change in gene expression at the end of the treatment using real-time polymerase chain reaction (PCR) and microarray assays. We showed that the immobility time in the water-administered control (FST stress) group gradually increased from day 1 to day 14. However, treatment with EEB caused a significant decrease of immobility time in the FST compared with that in the FST stress group. Microarray and real-time PCR results revealed that EEB treatment induced variation in the expression of several genes associated with neurogenesis, energy metabolism, and dopamine synthesis. Interestingly, we revealed that only EEB treatment enhanced the promotion of energy production, while treatment with imipramine was ineffective. Our study provides the first evidence that B. braunii enhances energy production, which may contribute to the modulation of neurogenesis and to the enhancement of dopaminergic function, in turn potentially underlying the antistress- and antidepressant-like effects that we observed.

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Section: Introductionmentioning

confidence: 99%

Modulation of Neurogenesis through the Promotion of Energy Production Activity Is behind the Antidepressant-Like Effect of Colonial Green Alga, Botryococcus braunii

et al. 2017

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“…24 5-HT, also known as serotonin, is a vasoactive substance and also a central neurotransmitter widely distributed in the CNS. 25,26 It is thought to be a neural regulatory system that interacts with other central nervous conductions in the brain tissue and participates in the adaptation of the CNS to external stimuli, 27 but also a signicant regulator of emotion, sleep and other physiological activities. 28 5-HT plays a physiological role by binding and activating the receptor.…”

Section: Resultsmentioning

confidence: 99%

The effect of beta-sitosterol and its derivatives on depression by the modification of 5-HT, DA and GABA-ergic systems in mice

Yin

Liu

et al. 2018

RSC Adv.

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Neurochemical factors associated with the antidepressant-like effect of flavonoid chrysin in chronically stressed mice

Filho

Jessé

Donato

et al. 2016

European Journal of Pharmacology

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Chrysin is a flavonoid which is found in bee propolis, honey and various plants. Antidepressant-like effect of chrysin in chronically stressed mice was previously demonstrated by our group. Conversely, neurochemical factors associated with this effect require further investigations. Thus, we investigated the possible involvement of pro-inflammatory cytokines, kynurenine pathway (KP), 5-hydroxytryptamine (5-HT) metabolism and caspases activities in the effect of chrysin in mice exposed to unpredictable chronic stress (UCS). UCS applied for 28 days induced a depressive-like behavior, characterized by decrease in the time of grooming in the splash test and by increase in the immobility time in the tail suspension test. Oral treatment with chrysin (5 or 20mg/kg, 28 days), similarly to fluoxetine (10mg/kg, positive control), culminated in the prevention of these alterations. UCS elevated plasma levels of corticotropin-releasing hormone and adrenocorticotropic hormone, as well the tumor necrosis factor-α, interleukin-1β, interleukin-6 and kynurenine levels in the prefrontal cortex (PFC) and hippocampus (HP). UCS induced the decrease in the 5-HT levels in the HP and the increase in the indoleamine-2,3-dioxygenase, caspase 3 and 9 activities in the PFC and HP. Treatment with chrysin, similarly to fluoxetine, promoted the attenuation of these alterations occasioned by UCS. These results corroborated with the antidepressant potential of chrysin in the treatment of psychiatric diseases. Furthermore, this work indicated the association of pro-inflammatory cytokines synthesis, KP, 5-HT metabolism and caspases activities with the action exercised by chrysin in mice exposed to UCS.

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Effects of Kaixin Powder on Expression of 5-HT Receptor in Hippocampus of Depressed Rats Induced by CUMS

Cited by 5 publications

References 5 publications

Modulation of Neurogenesis through the Promotion of Energy Production Activity Is behind the Antidepressant-Like Effect of Colonial Green Alga, Botryococcus braunii

Modulation of Neurogenesis through the Promotion of Energy Production Activity Is behind the Antidepressant-Like Effect of Colonial Green Alga, Botryococcus braunii

The effect of beta-sitosterol and its derivatives on depression by the modification of 5-HT, DA and GABA-ergic systems in mice

Neurochemical factors associated with the antidepressant-like effect of flavonoid chrysin in chronically stressed mice

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