Effects of JAM-A rs790056 and LFA-1 rs8058823 Variations on Kidney Cancer

Abstract

Objective: Kidney cancer is a type of cancer that includes different histology subgroups, and the number of kidney cancer cases is expected to increase. It has been found that the junctional adhesion molecule A (JAM-A) as a transmembrane glycoprotein is associated with cancer characteristics such as invasion, metastasis, and poor prognosis. Therefore, we aimed to investigate the effect of gene variations in JAM-A and its ligand lymphocyte function-related antigen-1 (LFA-1) on kidney cancer. Methods: DNA was isolated from 50 renal tumors and 50 healthy peripheral tissues. Gene variants of DNA samples were analyzed using the polymerase chain reaction and restriction fragment length polymorphism methods. The Statistical Package for Social Sciences version 22.0 (IBM Corp., Armonk, NY, USA) was used for statistical analysis, and p<0.05 was accepted as statistically significant. Results: Genotype and allele distributions of JAM-A rs790056 and LFA-1 rs8058823 were similar in tumor and healthy peripheral tissues (p>0.05). Conclusion: In our study, it was observed that JAM-A rs790056 and LFA-1 rs8058823 had no effect on kidney cancer.

Analysis of JAM-A T>C (rs790056) and LFA-1 2120 G>C (rs2230433) gene variations in uterine leiomyoma

“…Therefore, we aimed to determine the distributions of JAM-A rs790056 and LFA-1 rs2230433 variations in patients with leiomyoma, as well as their individual and combined effects. So far, studies investigating JAM-A and LFA-1 have been related to melanoma, coronary artery diseases (22), atherosclerosis (23), breast cancer ( 16), cerebral ischemiareperfusion injury (24), kidney cancer (25)and colorectal cancers (26). To our knowledge, JAM-A and LFA-1 gene variations in leiomyoma have been investigated for the first time in our study.…”