Effects of isotretinoin on the inflammatory markers and the platelet counts in patients with acne vulgaris

Seçkin, Havva Yıldız; Baş, Yalçın; Takçı, Zennure; Kalkan, Göknur

doi:10.3109/15569527.2015.1021927

Cited by 14 publications

(25 citation statements)

References 24 publications

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“…The mean age of the patients was 23.03 ± 4.35 years. The median (minimum-maximum) age of the patients was 22 (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37).…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, neutrophil lymphocyte rate decreased, and platelet lymphocyte rate was increased by isotretinoin. However, these changes were not statistically significant (28). Ozuguz et al suggested that isotretinoin might increase the monocyte count and decrease hemoglobin levels, red blood cell count, and MCV.…”

Section: Lee Et Al Reviewed the Laboratory Changes In Patients With mentioning

confidence: 96%

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Is mean platelet volume an inflammatory marker in acne patients treated with isotretinoin?

Tamer

Yüksel

Avcı³

2019

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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Introduction: Isotretinoin is a commonly used systemic retinoid for treating acne. However, isotretinoin may lead to elevated serum levels of triglycerides and cholesterol, and it may affect liver function tests. Moreover, the effect of isotretinoin on hematological parameters remains controversial. This study examines changes in the blood chemistry panel, hematological parameters, and inflammation biomarkers of patients diagnosed with acne and treated with isotretinoin. Methods: The study included 70 patients (59 females and 11 males, between ages 18 and 37) with moderate to severe acne vulgaris treated with isotretinoin. The medical records and laboratory findings of the participants were reviewed retrospectively between March 2017 and September 2018. All the patients whose necessary laboratory test results could be obtained from the collected data were included in the study. Results: Serum total cholesterol, HDL, LDL, triglyceride, mean corpuscular hemoglobin levels, and platelet/lymphocyte ratio increased, whereas white blood cell count and mean platelet volume (p = 0.036) decreased after isotretinoin treatment. Conclusions: The results of this study revealed that mean platelet volume decreased significantly 3 months after the initiation of isotretinoin treatment. Therefore, we suggest considering mean platelet volume as an inflammatory marker in patients with acne treated with isotretinoin. However, this research should be replicated under more randomized conditions in a prospective study to reach a definitive conclusion.

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Section: Resultsmentioning

confidence: 99%

Section: Lee Et Al Reviewed the Laboratory Changes In Patients With mentioning

confidence: 96%

Is mean platelet volume an inflammatory marker in acne patients treated with isotretinoin?

Tamer

Yüksel

Avcı³

2019

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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“…Similarly, recent studies have shown that these elevated levels of systemic inflammatory markers (NLR, PLR, RDW, and MPV) are associated with severity of many diseases, such as cancer, psoriasis, systemic lupus erythematosus, and acne vulgaris [15,17–20]. Similar parameters, such as metastatic lymph node ratios, are new and emerging parameters for various cancers [21,22].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Atopic Dermatitis Patients

Jiang

2017

Med Sci Monit

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BackgroundTo develop new strategies for identifying atopic dermatitis patients, a better understanding of the signs for chronic inflammatory status is needed. This study was designed to investigate whether neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are related to the severity of atopic dermatitis (AD) assessed by the Scoring Atopic Dermatitis (SCORAD) index.Material/MethodsA retrospective study involving 80 AD patients and 45 healthy control subjects was performed. NLR, PLR, and the number of peripheral blood eosinophils were compared between AD patients and healthy controls, and correlations between these indexes and clinical characteristics were analyzed.ResultsNLR, PLR, and eosinophils in AD patients were all significantly higher than in healthy individuals. Among AD patients, NLR (p<0.001) and PLR (p<0.001), as contrasted with eosinophils (p=0.146), were correlated positively with SCORAD index. Additionally, an NLR level of 1.75 was determined as the predictive cut-off value of severe AD (SCORAD ≥51) (sensitivity 94.7%, specificity 58.6%, the area under the receiver-operating characteristic curve (AUROC) 0.778, p=0.001). For eosinophils, the sensitivity and specificity were 78.9% and 62.1%, respectively, and the AUROC was only 0.685 (p=0.032) in predicting high SCORAD.ConclusionsNLR and PLR reflect inflammatory response and disease severity in AD patients.

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“…It was first introduced in 1982 and has been used ever since to treat acne and it belongs to the first generation of synthetic 13-cis retinoic acid compounds. 1 Isotretinoin is indicated for severe acne and moderate acne. 1 The classic recommended dose is 0.5 to 1.0 mg/kg/day for 6 months.…”

Section: Introductionmentioning

confidence: 99%

“…1 Isotretinoin is indicated for severe acne and moderate acne. 1 The classic recommended dose is 0.5 to 1.0 mg/kg/day for 6 months. 2 The drug entails various side effects that impact on many systems in the body.…”

Section: Introductionmentioning

confidence: 99%

Premature ventricular contractions associated with isotretinoin use

Alan

Ünal

Yıldırım

2016

An. Bras. Dermatol.

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Isotretinoin has been considered a unique drug for acne treatment. However, it is associated with numerous adverse effects. Isotretinoin can trigger premature ventricular contractions. This report describes a 33-year-old-woman who presented with palpitations for 1 week while undergoing 1-month isotretinoin treatment for mild-moderate facial acne. An electrocardiogram and Holter monitoring showed premature ventricular contractions during isotretinoin (Roaccutane, Roche) treatment. Isotretinoin-related premature ventricular contractions were strongly suggested in this case due to the existence of documented premature ventricular contractions on electrocardiograms and the disappearance of these premature ventricular contractions two weeks after termination of the treatment To the authors' knowledge, there has been 1 reported case of premature ventricular contractions linked to isotretinoin use; this report describes a second such case.

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Effects of isotretinoin on the inflammatory markers and the platelet counts in patients with acne vulgaris

Abstract: The oral isotretinoin treatment has been demonstrated as having increased the platelet density, hemoglobin levels and having decreased red-blood-cell distribution width level significantly.

Cited by 14 publications

References 24 publications

Is mean platelet volume an inflammatory marker in acne patients treated with isotretinoin?

Is mean platelet volume an inflammatory marker in acne patients treated with isotretinoin?

Assessment of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Atopic Dermatitis Patients

Premature ventricular contractions associated with isotretinoin use

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