Effects of isolated compounds from Catalpa ovata on the T cell-mediated immune responses and proliferation of leukemic cells

Oh, Chan‐Ho; Namseok, Kim; Yang, Jae‐Heon; Lee, Hyunjin; Yang, Seokwon; Park, Saerom; So, Un-Ki; Bae, Jin-Beom; Eun, Jae Soon; Jeon, Hoon; Lim, Jong Pil; Kwon, Jong Won; Kim, Young-Suk; Shin, Tae Yong; Kim, Dae Keun

doi:10.1007/s12272-010-0408-x

Cited by 11 publications

(5 citation statements)

References 10 publications

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“…Recent studies related to C. ovata have been mainly focused on the components with antitumor, anti-inflammatory, and fungal pathogen inhibition effects in the stem and bark [12,[14][15][16][17][18][19][20]. Besides, some relevant researches also put emphasis on the antioxidant, antitumor and anti-inflammatory of C. ovata leaves [9,19,21,22]. With respect to C. ovata seeds, some researchers have only reported that fatty acids in seed oil have an inhibitory effect on rodent colon cancer [23].…”

Section: Introductionmentioning

confidence: 99%

Composition of Catalpa ovata Seed Oil and Flavonoids in Seed Meal as Well as Their Antioxidant Activities

Zhu

Dong

et al. 2015

J Americ Oil Chem Soc

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In view of the growing demand for vegetable oil, currently exploration of some non‐conventional oils is of great concern. This study firstly analyzed the contents of fatty acids, phytosterols, and tocopherols in Catalpa ovata seed oil collected from four different Provinces in China. Then the composition of flavonoids as well as their antioxidant activities in defatted seed meal was determined. The results showed that the relative oil content in C. ovata seeds ranged from 24.0 to 36.0 % and seed oil was mainly composed of fatty acids linoleic acid (43.4–50.1 %), α‐linolenic acid (23.8–24.4 %), and oleic acid (13.1–16.2 %). The content of unsaturated fatty acids was up to 85.0 %. Sterol in seed oil mainly contained campesterol, stigmasterol, and β‐sitosterol. β‐sitosterol accounted for 74.0 % of the total sterol. The tocopherol content was 173.0–225.7 mg/100 g. Defatted seed meal from Hubei Province showed the highest content of total flavonoids (11 mg/g) and the strongest activities for DPPH radicals scavenging, ABTS radicals scavenging, and ferric reducing antioxidant power compared with other defatted seed meal in this study. Seven flavonoids were identified from C. ovata seed meal. These results suggest that C. ovata seeds may be developed as a new source of oil and can also be properly used in pharmaceuticals and cosmetics.

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Section: Introductionmentioning

confidence: 99%

Composition of Catalpa ovata Seed Oil and Flavonoids in Seed Meal as Well as Their Antioxidant Activities

Zhu

Dong

et al. 2015

J Americ Oil Chem Soc

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“…Mey., C. fargesii Bur., variant of C. tibetica Forrest, C. speciosa Ward., and C. fargesii f. duclouxii Dode, respectively. Previous phytochemical investigations indicated that iridoids and naphthoquinones were the main constituents of Catalpa plants [ 3 – 8 ]; C. ovata G. Don have showed antifungal activity [ 9 , 10 ], anti-inflammatory activity [ 11 – 15 ], antitumor activity [ 7 , 16 – 18 ], antioxidant activities [ 4 , 19 ], and so on. However, the bioactivity of other Catalpa plants was seldom reported.…”

Section: Introductionmentioning

confidence: 99%

Antioxidative Activities and Active Compounds of Extracts fromCatalpaPlant Leaves

Dong

et al. 2014

The Scientific World Journal

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In order to screen the Catalpa plant with high antioxidant activity and confirm the corresponding active fractions from Catalpa ovata G. Don, C. fargesii Bur., and C. bungei C. A. Mey., total flavonoid contents and antioxidant activities of the extracts/fractions of Catalpa plant leaves were determined. The determined total flavonoid content and antioxidant activity were used as assessment criteria. Those compounds with antioxidant activity were isolated with silica gel column chromatography and ODS column chromatography. Our results showed that the total flavonoid content in C. bungei C. A. Mey. (30.07 mg/g·DW) was the highest, followed by those in C. fargesii Bur. (25.55 mg/g·DW) and C. ovata G. Don (24.96 mg/g·DW). According to the determination results of total flavonoid content and antioxidant activity in 3 clones of leaves of C. bungei C. A. Mey., the total flavonoid content and antioxidant activity in crude extracts from C. bungei C. A. Mey. 6 (CA6) leaves were the highest. Moreover, the results showed that the total flavonoid content and antioxidant activities of ethyl acetate (EA) fraction in ethanol crude extracts in CA6 leaves were the highest, followed by n-butanol, petroleum ether (PE), and water fractions. Two flavonoid compounds with antioxidant activity were firstly isolated based on EA fraction. The two compounds were luteolin (1) and apigenin (2), respectively.

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“…Seven compounds (1, 4, 7-9, 12, and 13) were identified in the Smilacaceae family for the first time. The 16 known compounds were identified as trans-3,3 ,5,5 -tetrahydroxy-4methoxystilbene (1) [32], resveratrol (2) [33], 4-hydroxybenzoic acid (3) [34], 2-Ocaffeoylglycerol (4) [35], 1-O-caffeoylglycerol (5) [36], juncusyl ester B (6) [37], acertannin (7) [38], 2-O-(E)-feruloyl glyceride (8) [39], maplexin D (9) [40], trans-caffeic acid (10) [41], syringic acid (11) [42], 1-syringoyl-1,2-dihydroxyethane (12) [43], 3,5-dihydroxy-4-methoxybenzoic acid (13) [44], 1-(3,4,5-trimethoxyphenyl)-1,2,3-propanetriol ( 14) [45], 1-O-trans-ρ-coumaroylglycerol (15) [37], and trans-ρ-ethyl coumarate (19) [46] by comparing their spectroscopic data with reference values from the previously published literature.…”

Section: Chemical Identification Of Compounds 1-19mentioning

confidence: 99%

Anti-Adipogenic Activity of Secondary Metabolites Isolated from Smilax sieboldii Miq. on 3T3-L1 Adipocytes

Jung

Lee

et al. 2023

IJMS

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Smilax sieboldii, a climbing tree belonging to Smilacaceae, has been used in traditional oriental medicine for treating arthritis, tumors, leprosy, psoriasis, and lumbago. To evaluate the anti-obesity effects of S. sieboldii (Smilacaceae), we screened methylene chloride (CH2Cl2), ethyl acetate (EtOAc), aqueous-saturated n-butanol, and ethanol (EtOH) extracts of the whole plant at various concentrations to inhibit adipogenesis in adipocytes. The 3T3-L1 cell line with Oil red O staining with the help of fluorometry was used as an indicator of anti-obesity activity. Bioactivity-guided fractionation of the EtOH extract and subsequent phytochemical investigation of the active CH2Cl2- and EtOAc-soluble fractions resulted in the isolation of 19 secondary metabolites (1–19), including a new α-hydroxy acid derivative (16) and two new lanostane-type triterpenoids (17 and 18). The structures of these compounds were characterized using various spectroscopic methods. All the isolated compounds were screened for adipogenesis inhibition at a concentration of 100 μM. Of these, compounds 1, 2, 4–9, 15, and 19 significantly reduced fat accumulation in 3T3-L1 adipocytes, especially compounds 4, 7, 9, and 19, showing 37.05 ± 0.95, 8.60 ± 0.41 15.82 ± 1.23, and 17.73 ± 1.28% lipid content, respectively, at a concentration of 100 μM. These findings provide experimental evidence that isolates from S. sieboldii extracts exert beneficial effects regarding the regulation of adipocyte differentiation.

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Effects of isolated compounds from Catalpa ovata on the T cell-mediated immune responses and proliferation of leukemic cells

Cited by 11 publications

References 10 publications

Composition of Catalpa ovata Seed Oil and Flavonoids in Seed Meal as Well as Their Antioxidant Activities

Composition of Catalpa ovata Seed Oil and Flavonoids in Seed Meal as Well as Their Antioxidant Activities

Antioxidative Activities and Active Compounds of Extracts fromCatalpaPlant Leaves

Anti-Adipogenic Activity of Secondary Metabolites Isolated from Smilax sieboldii Miq. on 3T3-L1 Adipocytes

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