Effects of ischemia on pulmonary dysfunction after cardiopulmonary bypass

Chai, Paul J.; Williamson, Justin; Lodge, Andrew J.; Daggett, Casey W.; Scarborough, John; Meliones, Jon N.; Cheifetz, Ira M.; Jaggers, James; Ungerleider, Ross M.

doi:10.1016/s0003-4975(99)00096-x

Cited by 118 publications

(76 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In common with CPB, blood transfusion by itself stimulates systemic inflammatory cytokine production. 17,18 Thus, homologous blood use for CPB priming may also be a risk to cerebral blood flow and function. 19 Artificial oxygen carriers could be a breakthrough that helps solve this dilemma.…”

Section: Discussionmentioning

confidence: 99%

Use of Hemoglobin Vesicles During Cardiopulmonary Bypass Priming Prevents Neurocognitive Decline in Rats

et al. 2006

View full text Add to dashboard Cite

Background— Homologous blood use is considered to be the gold standard for cardiopulmonary bypass (CPB) priming in infants despite exposure of the patient to potential cellular and humoral antigens. However, the use of hemoglobin vesicles (HbVs), artificial oxygen carriers that encapsulate a concentrated hemoglobin solution within phospholipid bilayer membranes, for CPB priming may prevent neurocognitive decline in infants. The goal of this study was to determine whether HbV use offsets hemodilution caused by patient/priming volume-mismatched CPB and thereby prevents the development of postoperative neurocognitive deficits. Methods and Results— CPB was established in 28 male Sprague-Dawley rats (age, 14 to 16 weeks; weight, 450 grams) after cannulation of the tail artery and right atrium. The animals were randomly assigned to 1 of 3 groups: sham surgery (n=9), HbV (−) prime (n=10), or HbV (+) prime (n=9). CPB was conducted for 90 minutes at 200 mL/kg per minute. The hematocrit during CPB was 10.0±1.2% in the HbV (+) prime group and 9.9±1.3% in the HbV (−) prime group ( P =not significant). Learning and memory function were evaluated using 2 different maze tests (Maze-1 and Maze-2, in which the arrival times to the target were measured on the first, third, fifth, and seventh postoperative days). Learning and memory function were significantly better in the HbV (+) prime group than in the HbV (−) prime group (Maze-1, P =0.012; Maze-2, P =0.042); there was no difference between the HbV (+) prime and the sham surgery group. Conclusions— The use of HbV for CPB priming may serve as a substitute for homologous blood to prevent the unacceptable hemodilution and contribute to maintenance of intact neurocognitive function.

show abstract

Section: Discussionmentioning

confidence: 99%

Use of Hemoglobin Vesicles During Cardiopulmonary Bypass Priming Prevents Neurocognitive Decline in Rats

et al. 2006

View full text Add to dashboard Cite

show abstract

“…These phenomena serve as the basis of early systemic inflammatory response syndrome after open cardiac surgery and explain the reason of sepsis to arise starting from the third day after the surgery. In our study, all incidence of sepsis was diagnosed on day three (the 72 nd hour) until day five (the 122 nd hour) after surgery ( 23 and associates who demonstrated that patients who underwent CPB for more than 90 minutes resulted in a more severe pulmonary injury compared to those who were less than 90 minutes in CPB. Additionally, a longer CPB time disrupts the normal functioning of kidney, nervous system, and gastrointestinal tract; thus, increases morbidity and mortality after surgery.…”

Section: Discussionmentioning

confidence: 53%

“…Additionally, a longer CPB time disrupts the normal functioning of kidney, nervous system, and gastrointestinal tract; thus, increases morbidity and mortality after surgery. [23][24][25][26][27][28][29] Gastrointestinal tract vascular integrity and perfusion were disrupted (i.e. sphlanchnic hypoperfusion) by a long CPB time (>90 minutes).…”

Section: Discussionmentioning

confidence: 99%

Risk factors of sepsis after open congenital cardiac surgery in infants: a pilot study

Fakhri¹,

Busro²,

Rahmat³

et al. 2016

Med J Indones

View full text Add to dashboard Cite

ABSTRAK (80% vs 25%, RR=5,538, p=0,006). Secara statistik, gizi kurang (86% vs 84%, RR=1,059, p=1,000), timektomi (50% vs 76%, RR=0,481, p=0,157) ABSTRACTBackground: Postsurgical sepsis is one of the main causes of the high mortality and morbidity after open congenital heart surgery in infants. This study aimed to evaluate the role of cardiopulmonary bypass duration, thymectomy, surgical complexity, and nutritional status on postsurgical sepsis after open congenital cardiac surgery in infants.

show abstract

“…Since recent investigations imply that pulmonary dysfunction may be related to an ischemic injury of the lung during CPB (Cai et al 1999), further studies are necessary to find out whether the reasons for pulmonary dysfunction is related to ischemia of the lung. …”

Section: Discussionmentioning

confidence: 99%

Alveolar Recruitment Strategy During Cardiopulmonary Bypass Does Not Improve Postoperative Gas Exchange and Lung Function

et al. 2009

View full text Add to dashboard Cite

Pulmonary dysfunction with impairment of lung function and oxygenation is one of the most serious problems in the early postoperative period after cardiac surgery. In this study we investigated the effect of alveolar recruitment strategy during cardiopulmonary bypass on postoperative gas exchange and lung function. This prospective randomized study included 32 patients undergoing elective myocardial revascularization with cardiopulmonary bypass. In 16 patients 5 cm H(2)O of positive end-expiratory pressure was applied after intubation and maintained until extubation (Group I). In the other 16 patients (group II) a positive end expiratory pressure (PEEP) of 5 cm H(2)O was maintained as well but was increased to 14 cm H(2)O every 20 min for 2 min during cross clamp. Measurements were taken preoperatively, before skin incision, before and after (3, 24, 48 h) cardiopulmonary bypass and before discharge (6th postoperative day). Postoperative gas exchange, extravascular lung water and lung function showed no significant difference between the groups. Postoperative pulmonary function variables were lower in both groups compared to baseline values. In patients with normal preoperative pulmonary function, application of an alveolar recruitment strategy during cardiopulmonary bypass does not improve postoperative gas exchange and lung function after cardiac surgery.

show abstract

Effects of ischemia on pulmonary dysfunction after cardiopulmonary bypass

Cited by 118 publications

References 18 publications

Use of Hemoglobin Vesicles During Cardiopulmonary Bypass Priming Prevents Neurocognitive Decline in Rats

Use of Hemoglobin Vesicles During Cardiopulmonary Bypass Priming Prevents Neurocognitive Decline in Rats

Risk factors of sepsis after open congenital cardiac surgery in infants: a pilot study

Alveolar Recruitment Strategy During Cardiopulmonary Bypass Does Not Improve Postoperative Gas Exchange and Lung Function

Contact Info

Product

Resources

About