Effects of ischemia and H2O2 on the cold stress protein CIRP expression in rat neuronal cells

Xue, Jing; Nonoguchi, Kohsuke; Fukumoto, Manabu; Sato, Tomoe; Nishiyama, Hiroyuki; Higashitsuji, Hiroaki; Itoh, Katsuhiko; Fujita, Jun

doi:10.1016/s0891-5849(99)00158-6

Cited by 80 publications

(59 citation statements)

References 31 publications

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“…Under this definition, the best-characterized cold shock protein to date is CIRP, a 172-amino acid (in mouse) protein containing an RNA-binding domain (77). A CIRP gene has been detected in mouse, rat, and human cells, and its sequence is highly conserved in these species (76,77,115). The mRNA encoding this protein is expressed constitutively in most tissues of adult mice at relatively low levels.…”

Section: Cold-induced Changes In Gene Expression and Cold Shock Proteinsmentioning

confidence: 99%

Invited Review: Effects of heat and cold stress on mammalian gene expression

Sonna

Fujita

Gaffin

et al. 2002

Journal of Applied Physiology

Self Cite

545

409

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This review examines the effects of thermal stress on gene expression, with special emphasis on changes in the expression of genes other than heat shock proteins (HSPs). There are ∼50 genes not traditionally considered to be HSPs that have been shown, by conventional techniques, to change expression as a result of heat stress, and there are <20 genes (including HSPs) that have been shown to be affected by cold. These numbers will likely become much larger as gene chip array and proteomic technologies are applied to the study of the cell stress response. Several mechanisms have been identified by which gene expression may be altered by heat and cold stress. The similarities and differences between the cellular responses to heat and cold may yield key insights into how cells, and by extension tissues and organisms, survive and adapt to stress.

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Section: Cold-induced Changes In Gene Expression and Cold Shock Proteinsmentioning

confidence: 99%

Invited Review: Effects of heat and cold stress on mammalian gene expression

Sonna

Fujita

Gaffin

et al. 2002

Journal of Applied Physiology

Self Cite

545

409

View full text Add to dashboard Cite

show abstract

“…CIRP was the first protein identified that was induced following reduction of temperature in mammalian cells (Nishiyama et al 1997a, b). Apart from CHO, CIRP has been detected in mouse, rat, and human cells, and its sequence is highly conserved in these species (Nishiyama et al 1997a, b;Xue et al 1999). The expression of CIRP has also been observed increasing at exposures to other stress conditions, such as ultraviolet radiation or hypoxia, although heat stress dose not affect CIRP levels (Nishiyama et al 1997a, b;Fujita et al 1999;Yang and Carrier 2001).…”

Section: The Use Of Cell Cycle Arrest To Increase Recombinant Proteinmentioning

confidence: 99%

Proliferation control strategies to improve productivity and survival during CHO based production culture

2007

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Chinese Hamster Ovary cells are the primary system for the production of recombinant proteins for therapeutic use. Protein productivity is directly proportional to viable biomass, viability and culture longevity of the producer cells and a number of approaches have been taken to optimise these parameters. Cell cycle arrest, particularly in G1 phase, typically using reduced temperature cultivation and nutritional control have been used to enhance productivity in production cultures by prolonging the production phase, but the mechanism by which these approaches work is still not fully understood. In this article, we analyse the public literature on proliferation control approaches as they apply to production cell lines with particular reference to what is known about the mechanisms behind each approach.

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“…Additionally, it is reported that CIRP is constitutively expressed in the testis, lung, heart, kidney, hippocampus and cerebral cortex of the adult rat [15]. In this study, when comparing the expression level of CIRP mRNA and protein from female and male yaks' tissues, no significant sex-differences were found.…”

Section: Discussionmentioning

confidence: 49%

“…Except for its role in the cell growth inhibition caused by cold, CIRP as a critical factor has been involved in the tumour suppressor, pathogenesis of tumour genesis, and played a regulatory role in stresses such as ultraviolet radiation and tissue hypoxia [5]. Also there are some studies on the CIRP in the human [2], amphibian [11], rat and mouse [8,15,16]. Despite all this, there is no research about the CIRP of native plateau species which live under extreme hypoxia, hypothermia and UV radiation conditions.…”

Section: Introductionmentioning

confidence: 99%