Effects of irrigation fluid temperature on choroidal circulation during vitrectomy

Tamai, Kazushi; Toumoto, Eiji; Yamada, Kiyoshi; Ogura, Yuichiro

doi:10.1076/ceyr.18.4.249.5361

Cited by 7 publications

(4 citation statements)

References 10 publications

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“…Our work in chicks with myopia-inducing goggles and ophthalmic nerve cuts, for example, suggests that the sensory input to the choroid may be involved in temperature-dependent regulation of ChBF (Shih et al, 1999). Consistent with the idea that ChBF can respond to temperature, ChBF in rabbits has been reported to increase with retinal cooling below or heating above 34 °C, and thereby maintain constant retinal temperature with ambient temperatures ranging from 30 to 40 °C (Tamai et al, 1999). Similarly, Stiehl et al (1986) showed that retinal temperature remains relatively constant during cooling of the conjunctiva in cats by up to 6 °C.…”

Section: Trigeminal Sensory Input To Choroidsupporting

confidence: 53%

“…For example, reduced ocular blood flow caused by elevated IOP has been shown to result in reduced scleral and retinal temperature (Auker et al, 1982; Bill et al, 1983). Moreover, heating an eye in which blood flow has been reduced by elevation of IOP (which reduces ocular perfusion pressure and ChBF) results in an exaggerated rise in ocular temperature compared to eyes at normal IOP, suggesting that ChBF can play a role in thermoregulatory ocular cooling as well (Bill et al, 1983), as indicated also by Tamai et al (1999). ChBF-dependent thermoregulation may be important for retinal homeostasis and function (Parver et al, 1980).…”

Section: Trigeminal Sensory Input To Choroidmentioning

confidence: 99%

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Neural control of choroidal blood flow

Reiner

Fitzgerald

Mar

et al. 2018

Progress in Retinal and Eye Research

147

128

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The choroid is richly innervated by parasympathetic, sympathetic and trigeminal sensory nerve fibers that regulate choroidal blood flow in birds and mammals, and presumably other vertebrate classes as well. The parasympathetic innervation has been shown to vasodilate and increase choroidal blood flow, the sympathetic input has been shown to vasoconstrict and decrease choroidal blood flow, and the sensory input has been shown to both convey pain and thermal information centrally and act locally to vasodilate and increase choroidal blood flow. As the choroid lies behind the retina and cannot respond readily to retinal metabolic signals, its innervation is important for adjustments in flow required by either retinal activity, by fluctuations in the systemic blood pressure driving choroidal perfusion, and possibly by retinal temperature. The former two appear to be mediated by the sympathetic and parasympathetic nervous systems, via central circuits responsive to retinal activity and systemic blood pressure, but adjustments for ocular perfusion pressure also appear to be influenced by local autoregulatory myogenic mechanisms. Adaptive choroidal responses to temperature may be mediated by trigeminal sensory fibers. Impairments in the neural control of choroidal blood flow occur with aging, and various ocular or systemic diseases such as glaucoma, age-related macular degeneration (AMD), hypertension, and diabetes, and may contribute to retinal pathology and dysfunction in these conditions, or in the case of AMD be a precondition. The present manuscript reviews findings in birds and mammals that contribute to the above-summarized understanding of the roles of the autonomic and sensory innervation of the choroid in controlling choroidal blood flow, and in the importance of such regulation for maintaining retinal health.

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Section: Trigeminal Sensory Input To Choroidsupporting

confidence: 53%

Section: Trigeminal Sensory Input To Choroidmentioning

confidence: 99%

Neural control of choroidal blood flow

Reiner

Fitzgerald

Mar

et al. 2018

Progress in Retinal and Eye Research

147

128

View full text Add to dashboard Cite

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“…Indeed, our results show that Trpm8 −/− mice exhibit a higher drop in Teye than controls when exposed to mild cold. Consistent with our findings, a previous study revealed that temperature in the vitreous chamber above or below 34°C induces an increase in choroidal blood flow (ChBF), and only when intraocular temperature falls below 16°C, the ChBF decreases 42 . We therefore propose that mild drops of temperature inside the eye would be detected by TRPM8 channels in the sensory trigeminal fibres innervating choroidal vasculature, which will produce an increase in ChBF to maintain the intraocular temperature.…”

Section: Discussionsupporting

confidence: 91%

“…Consistent with our findings, a previous study revealed that temperature in the vitreous chamber above or below 34°C induces an increase in choroidal blood flow (ChBF), and only when intraocular temperature falls below 16°C, the ChBF decreases. 42 We therefore propose that mild drops of temperature inside the eye would be detected by TRPM8 channels in the sensory trigeminal fibres innervating choroidal vasculature, which will produce an increase in ChBF to maintain the intraocular temperature. Whether vasodilation is mediated by F I G U R E 7 Liver and gonadal WAT are innervated by TRPM8-positive sensory fibre and TRPM8 regulates peripheral clocks in these tissues.…”

Section: Trpm8 Regulates Clockwork In Liver and Fatmentioning

confidence: 99%

The cold‐sensing ion channel TRPM8 regulates central and peripheral clockwork and the circadian oscillations of body temperature

et al. 2022

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Aim: Physiological functions in mammals show circadian oscillations, synchronized by daily cycles of light and temperature. Central and peripheral clocks participate in this regulation. Since the ion channel TRPM8 is a critical cold sensor, we investigated its role in circadian function. Methods:We used TRPM8 reporter mouse lines and TRPM8-deficient mice. mRNA levels were determined by in situ hybridization or RT-qPCR and protein levels by immunofluorescence. A telemetry system was used to measure core body temperature (Tc). Results: TRPM8 is expressed in the retina, specifically in cholinergic amacrine interneurons and in a subset of melanopsin-positive ganglion cells which project to the central pacemaker, the suprachiasmatic nucleus (SCN) of the hypothalamus. TRPM8-positive fibres were also found innervating choroid and ciliary body vasculature, with a putative function in intraocular temperature, as shown in TRPM8-deficient mice. Interestingly, Trpm8 −/− animals displayed increased expression of the clock gene Per2 and vasopressin (AVP) in the SCN, suggesting a regulatory role of TRPM8 on the central oscillator. Since SCN AVP neurons control body temperature, we studied Tc in driven and free-running conditions.

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Effect of isoflurane anaesthetic time on ocular a-scan ultrasonography measures and their relationship to age and OCT measures in the Guinea pig

Myles,

Abdulla,

McFadden

2024

Experimental Eye Research

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Effects of irrigation fluid temperature on choroidal circulation during vitrectomy

Abstract: The choroid acts as a thermostat to minimize intraocular temperature fluctuations by changing its blood flow.

Cited by 7 publications

References 10 publications

Neural control of choroidal blood flow

Neural control of choroidal blood flow

The cold‐sensing ion channel TRPM8 regulates central and peripheral clockwork and the circadian oscillations of body temperature

Effect of isoflurane anaesthetic time on ocular a-scan ultrasonography measures and their relationship to age and OCT measures in the Guinea pig

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