Effects of irradiation on the expression of major histocompatibility complex class I antigen and adhesion costimulation molecules ICAM-1 in human cervical cancer

Santin, Alessandro D.; Hermonat, Paul L.; Hiserodt, John C.; Chiriva‐Internati, Maurizio; Woodliff, Jeffrey; Theus, John; Barclay, David; Pecorelli, Sërgio; Parham, Groesbeck P.

doi:10.1016/s0360-3016(97)00372-6

Cited by 57 publications

(37 citation statements)

References 16 publications

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“…Thus the elevated expression of class I molecules following RT could help in tumor recognition as well as for antigen transport. Similar elevation of MHC expression following irradiation has also been reported by others [18,19,20]. Moreover, Wang et al [20 ]have shown in their study that irradiation could also contribute to increasing the permeability of tumors thereby facilitating the infiltration of inflammatory cells.…”

Section: Discussionsupporting

confidence: 84%

Flt3L Therapy following Localized Tumor Irradiation Generates Long-Term Protective Immune Response in Metastatic Lung Cancer: Its Implication in Designing a Vaccination Strategy

et al. 2006

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Flt3 ligand (Flt3L) therapy that expands dendritic cells in vivo in combination with local tumor radiotherapy (RT) significantly improved survival and induced a long-term tumor-specific immune response in a murine model of Lewis lung carcinoma (3LL). The irradiated tumor cells were able to significantly restimulate the splenocytes of the RT + Flt3L cohort in vitro. The restimulated splenocytes demonstrated increased cytotoxic response, lymphocytic proliferation and elevated levels of Th type I cytokines (IL-2, IL-12, IFN-γ and TNF-α). The combination therapy of RT + Flt3L induced a long-term protective immunity in the disease-free animals. The protective effect was further enhanced when the disease-free animals were vaccinated with irradiated tumor cells. The vaccinated animals had significantly greater protection compared to the nonvaccinated group against subsequent challenge with 3LL cells. Taken together, these results indicate that the release of tumor antigens by irradiated dying tumors and concomitant administration of Flt3L was able to facilitate the generation of a tumor-specific long-term immune response against a poorly immunogenic tumor. This effect was further boosted by vaccination with irradiated tumor cells.

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Section: Discussionsupporting

confidence: 84%

Flt3L Therapy following Localized Tumor Irradiation Generates Long-Term Protective Immune Response in Metastatic Lung Cancer: Its Implication in Designing a Vaccination Strategy

et al. 2006

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“…However, it is unclear what dose of radiation is given to each tumor cell, and the result may be that some tumor cells are killed while others are phenotypically modified. Although a single, sublethal, low dose of radiation (Յ20Gy) was used in this study, previous studies suggest that similar protein level increases are observed at higher doses of radiation (6,40). In addition, fractionation, as radiation is often given in the clinic, achieved similar response rates both in vitro and in vivo similar to that of a bolus dose in a preclinical model (6,47).…”

Section: Radiation Of Tumors Enhances Ctl Sensitivitymentioning

confidence: 80%

Sublethal Irradiation of Human Tumor Cells Modulates Phenotype Resulting in Enhanced Killing by Cytotoxic T Lymphocytes

et al. 2004

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ABSTRACT؉ CTLs compared with nonirradiated counterparts. We then used microarray analysis to broaden the scope of observed changes in gene expression after radiation and found that many additional genes had been modulated. These up-regulated gene products may additionally enhance the tumor cells' susceptibility to T-cell-mediated immune attack or serve as additional targets for immunotherapy. Overall, the results of this study suggest that nonlethal doses of radiation can be used to make human tumors more amenable to immune system recognition and attack and form the rational basis for the combinatorial use of cancer vaccines and local tumor irradiation.

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“…1). The up-regulation of MHC class I on human and mouse tumor cells in vitro has been reported in various studies following 10 -100 Gy of radiation (39,40). In addition, overexpression of ICAM-1 on tumor cells has been associated with increased sensitivity to CTL-mediated lysis (41).…”

Section: Discussionmentioning

confidence: 99%

External Beam Radiation of Tumors Alters Phenotype of Tumor Cells to Render Them Susceptible to Vaccine-Mediated T-Cell Killing

Chakraborty¹,

Abrams²,

et al. 2004

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Effects of irradiation on the expression of major histocompatibility complex class I antigen and adhesion costimulation molecules ICAM-1 in human cervical cancer

Cited by 57 publications

References 16 publications

Flt3L Therapy following Localized Tumor Irradiation Generates Long-Term Protective Immune Response in Metastatic Lung Cancer: Its Implication in Designing a Vaccination Strategy

Flt3L Therapy following Localized Tumor Irradiation Generates Long-Term Protective Immune Response in Metastatic Lung Cancer: Its Implication in Designing a Vaccination Strategy

Sublethal Irradiation of Human Tumor Cells Modulates Phenotype Resulting in Enhanced Killing by Cytotoxic T Lymphocytes

External Beam Radiation of Tumors Alters Phenotype of Tumor Cells to Render Them Susceptible to Vaccine-Mediated T-Cell Killing

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