Effects of iron metabolism on tissue reaction for deep-seated mycosis.

Abe, Fumihiko; Katoh, Tadashi; Inaba, Hayashi

doi:10.3314/jjmm1960.30.254

Cited by 1 publication

(2 citation statements)

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“…Transferrin, which is present in the sera of human and mice, is well known to be a chelating protein for ferrous ion [11]. For example, mice with liver injury induced by D(+)-galactosamine were more susceptible to Candida infection due to decreased amount of transferrin [2,3]. Moreover, mice administrated with excess amount of iron die in early stage of Candida infection [2][3][4].…”

Section: Discussionmentioning

confidence: 99%

“…For example, mice with liver injury induced by D(+)-galactosamine were more susceptible to Candida infection due to decreased amount of transferrin [2,3]. Moreover, mice administrated with excess amount of iron die in early stage of Candida infection [2][3][4]. Thus, transferrin has been thought to play an important role in protection against fungal and bacterial infections [21].…”

Section: Discussionmentioning

confidence: 99%

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Candida albicans, Cryptococcus neoformans or Aspergillus fumigatus Induces an Antifungal Activity in Mouse Serum, which is Different from Transferrin

Okazaki

Asakura

Sugimoto

et al. 2009

The Journal of Veterinary Medical Science

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ABSTRACT. It has been reported that administration of Candida albicans into mouse induces an antifungal activity in serum, which has been identified as transferrin. In the present study, we show that not only C. albicans, but also other fungus such as Cryptococcus neoformans or Aspergillus fumigatus similarly can induce an antifungal activity in mouse serum. This antifungal activity was inhibited by the addition of ferrous ion, indicating that the growth inhibition of C. albicans was due to deficiency of ferrous ion, which may be caused by transferrin. Indeed, addition of transferrin in an in vitro assay system using RPMI1640 culture medium inhibited the growth of C. albicans, C. neoformans or A. fumigatus. However, when C. albicans was grown in RPMI1640 medium with 10% fetal bovine serum (FBS), transferrin was unable to inhibit the growth of C. albicans, in sharp contrast, when C. albicans treated mouse serum was added instead of FBS, the growth of the organism was inhibited. Similar results were obtained when C. neoformans or A. fumigatus was used. Taken together, the results suggest that antifungal activity induced by C. albicans, C. neoformans or A. fumigatus was not due to transferrin but likely due to other unknown serum proteins, which may cut off the source of iron for the growth of these fungi.

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